Cell adhesion: types, mechanisms, the role in functioning of living systems
Keywords:
cell adhesion molecules, cell-matrix adhesion, cell-cell adhesion, non-specific and specific adhesion
Abstract
Current understanding of cell adhesion, its molecular mechanisms and significance are being considered.
Cell adhesion molecules (CAMs) (integrins, cadherins, selectins, mucin, immunoglobulin superfamily)
and its role in tissue formation, development of tumoral processes, immune and inflammatory reactions
were described. There are two types of adhesion: cell-matrix and cell-cell adhesions. Receptors of most
families CAMs involve in the adhesion at both types of interactions. According to most researchers,
adhesion occurs in two stages. The first (non-specific) stage is made by physico-chemical factors. The
specific interaction between adhesives and cell or matrix receptor at the molecular level occurs at the
second adhesion stage. Complexes formed by cell adhesion receptors are not static, but are dynamic units
capable of obtaining and incorporating extracellular environmental signals, and are indeed the foundation
of two-way signaling between the cell and its environment. Adhesive properties are critical for start and
maintaince of three-dimensional structure and normal tissue function.
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References
1. Гистология / Н.В. Бойчук, Р.Р. Исламов, С.Л. Кузнецов, [и др.] – M.: ГЕОТАР-МЕД, 2001. – 672 с. /Gistologija / N.V. Bojchuk, R.R. Islamov, S.L. Kuznecov, [i dr.] – M.: GEOTAR-MED, 2001. – 672 s./
2. Гильберт С. Биология развития / С. Гильберт – М.: «Мир», 1995. - Т. 3. – 352 с. /Gilbert S. Biologiya razvitiya / S. Gilbert – M.: «Mir», 1995. - T. 3. – 352 s./
3. Lyons A.J. Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma / A.J. Lyons, J. Jones // Int J Oral Maxillofac Surg. – 2007. –V. 36. – P. 671-679.
4. Hynes R.O. Integrins: versatility, modulation, and signalling in cell adhesion / R.O. Hynes // Cell. – 1992. – V. 69. – P. 11-25.
5. Gogali A. Integrin receptors in primary lung cancer / A. Gogali, K. Charalabopoulos, S. Constantopoulos // Exp Oncol. – 2004. – V. 26. – P. 106-110.
6. Mousa S.A. Cell adhesion molecules: potential therapeutic and diagnostic implications / S.A. Mousa // Mol Biotechnol. – 2008. – V. 38. – P. 33-40.
7. Cell adhesion molecules / P.T. Cagle, T.C. Allen, [et al.] // Basic Concepts of Molecular Pathology, Molecular Pathology Library 2. - Springer Science + Business Media. – USA, 2009. – P.19-28.
8. Cadherin superfamily of adhesion molecules in primary lung cancer / K. Charalabopoulos, A. Gogali, O.K. Kostoula, [et al.] // Exp Oncol. - 2004. – V. 26. – P. 256-260.
9. Takeichi M. Cadherin cell adhesion receptors as morphogenetic regulator / M. Takeichi // Science. – 1991. – V. 251. – P. 1451-1459.
10. Kemler R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion / R. Kemler // Trends Genet. – 1993. – V. 9. – P. 317-321.
11. Ozawa M. The cytoplasmic domain of the cell adhesion molecule uvamorulin associates with three independent proteins structurally related in different species / M. Ozawa, H. Baribault, R. Kemler // EMBO J. - 1989 – V. 8. – P. 1711-1717.
12. Identification of a neural α -catenin as a key regulator of cadherin function and multicellular organization / S. Hirano, N. Kinoto, Y. Shimoyama, [et al.] // Cell. – 1992. – V. 70. – P. 293-301.
13. Molecular cloning and expression of murine vascular endothelial cadherin in early stage development of cardiovascular system / G. Breier, F. Breviario, L. Caveda, [et al.] // Blood. – 1996. – V. 87. – P. 630-641.
14. Selectins potential pharmacological targets / C. Kneuer, C. Ehrhardt, M.W. Radomski, [et al.] // Drug Discov Today. – 2006. – V. 11. – P. 1034-1040.
15. Petruzzelli L. Structure and function of cell adhesion molecules / L. Petruzzelli, M. Takami, H.D. Humes // Am J Med. – 1999. – V. 106. – P. 467-476.
16. Carlos T.M. Leukocyte-endothelial adhesion molecules / T.M. Carlos, J.M. Harlan // Blood. – 1994. – V. 84. – P. 2068-2101.
17. Springer T. Adhesion receptors of the immune system / T. Springer // Nature. – 1990. – V. 346. – P. 425-434.
18. Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins / A.E. Aplin, A. Howe, S.K. Alahari, [et al.] // Pharmacol Rev. – 1998. – V. 50. – P. 197-263.
19. Signal transduction by cell adhesion receptors / C. Rosales, V. O’Brian, L. Kornberg, [et al.] // Biochim Biophys Acta. – 1995. – V. 1242. – P. 77-98.
20. Nair K.S. Expression of cell adhesion molecules in oesophageal carcinoma and its prognostic value / K.S. Nair, R. Naidoo, R. Chetty // J Clin Pathol. – 2005. – V. 58. – P. 343–351.
21. Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition / K. Miyake, C.B. Underhill, J. Lesley, [et al.] // J. Exp. Med.- 1990. – V. 172. – P. 69-75.
22. Curtis A. S. G. Substrate hydroxylation and cell adhesion / A.S.G. Curtis, J.V. Forrester, P. Clark // J. Cell Sci. – 1998. – V. 86. – P. 9-24.
23. Mrksich M. A surface chemistry approach to studying cell adhesion / M. Mrksich // Chem. Soc. Rev. – 2000. – V. 29. – P. 267-273.
24. Increased adhesion of erythrocytes to components of the extracellular matrix: isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin / C.A. Hillery, M.C. Du, R.R. Montgomery, [et al.] // J. Blood. – 1996. – V. 87, № 11. – P. 4879-4886.
25. Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures / R. Hoover, R. Rubin, G. Wise, [et al.] // J. Blood. – 1979. – V. 54, № 4. – P. 872-876.
26. Walther B.T. A quantitative assay for intercellular adhesion / B.T. Walther, R. Ohman, S. Roseman // Proc Nat Acad Sci. USA. – 1973. – V. 70. – P. 1569.
27. Bell G. Models for the specific adhesion of cells to cells / G. Bell // Science. –1978. - V. 200. – P. 618-627.
28. Rutishnauser U. Neural cell adhesion between spinal cord molecule mediates initial interactions neurons and muscle cells in culture / U. Rutishnauser, M. Grumet, G.M. Edelman // J. Cell Biol. – 1983. – V. 97. – P. 145-152.
29. Takeichi M. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis / M. Takeichi // Development. – 1988. – V. 102. – P. 639-655.
30. Granger D.N. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion / D.N. Granger, P. Kubes // J. Leukocyte Biol. – 1994. – V. 55. – P. 639-655.
31. An Y.H. Mechanisms of bacterial adhesion and pathogenesis of implant and tissue infection / Y.H. An, R.B. Dickinson, R.J. Doyle // Handbook of bacterial adhesion: principles, methods and applications.-Human Press, Totowa. – 2000. – P. 1-27.
32. Dubreuil J.D. Helicobacter pylori interaction with host serum and extracellular matrix proteins: potential role in the infectious process / J.D. Dubreuil, G. Del Giudice, R. Rappuoli // Microbiol. Mol. Biol. Rev. - 2002. - V. 66, № 4. - P. 617-629.
33. Dunne W.M. Bacterial adhesion: seen any good biofilms lately? / W.M. Dunne // Clin. Microbiol. Rev. – 2002. – V.15, № 8. – P. 155-166.
34. Дмитриева Н.Ф. Липотейхоевые и тейхоевые кислоты патогенных стрептококков: структура, функции, роль во взаимодействии возбудителя с макроорганизмом / Н.Ф. Дмитриева, Ю.М. Тимофеев, Н.И. Брико // Журн. Микробиологии, епидемологии и иммунобиологии. – 2007. – № 6. – С. 100-107. /Dmitriyeva N.F. Lipoteykhoyevye i teykhoyevye kisloty patogennykh streptokokkov: struktura, funktsii, rol vo vzaimodeystvii vozbuditelja s makroorganizmom / N.F. Dmitriyeva, Yu.M. Timofeyev, N.I. Briko // Zhurn. Mikrobiologii, epidemologii i immunobiologii. – 2007. – № 6. – S. 100-107./
35. Jones G.W. Proteinaceous bacterial adhesions and their receptors / G.W. Jones, R.E. Isaacson // Crit. Rev. Microbiol. – 1983. – V. 10. – P. 29-260.
36. Plotkin B.J. Adherence of Bordetella bronchisseptica to hamster lung fibroblasts / B.J. Plotkin, D.A. Bevis // Infect Immun. – 1984. – V. 46, № 11. – P. 697-702.
37. Поспелова С.В. Изучение адгезивных свойств микроорганизмов, выделенных от больных с патологией гепатобиллиарной системы / С.В. Поспелова, Т.И. Карпунина, Н.А. Зубарева // Пермский мед. журнал. - 1998. - Т. 15, №3. - С. 22-25. /Pospelova S.V. Izucheniye adgezivnyh svoystv mikroorganizmov, vydelennyh ot bolnyh s patologiyey gepatobilliarnoy sistemy / S.V. Pospelova, T.I. Karpunina, N.A. Zubareva // Permskiy med. zhurnal. - 1998. - T. 15, №3. - S. 22-25./
38. Кlemm P. Bacterial adhesions: function and structure / P. Кlemm, M.A. Schembri // Int. J. Med. Microbiol. - 2000. – V. 290. – P. 27-35.
39. Иванова В.В. Закономерности взаимоотношений макроорганизма и возбудителей инфекционных болезней у детей / В.В. Иванова, Е.А. Корнева // Вестник РАМН. – 2000. – №11. – С. 35-40. /Ivanova V.V. Zakonomernosti vzaimootnosheniy makroorganizma i vozbuditeley infektsionnyh bolezney u detey / V.V. Ivanova, Ye.A. Korneva // Vestnik RAMN. - 2000. – №11. – S. 35-40./
40. Мавзютов А.Р. Факторы патогенности оппортунистических ентеробактерий и их роль в развитии диареи /А.Р Мавзютов., В.М. Бондаренко, Н.Ю. Жеребцова // Журн. Микробиол. – 2007. – №1. – С. 89-97. /Mavzyutov A.R. Faktory patogennosti opportunisticheskih enterobakterij i ih rol’ v razvitii diarei / A.R Mavzyutov., V.M. Bondarenko, N.Yu. Zherebtsova // Zhurn. Mikrobiol. – 2007. – № 1. – S. 89-97./
2. Гильберт С. Биология развития / С. Гильберт – М.: «Мир», 1995. - Т. 3. – 352 с. /Gilbert S. Biologiya razvitiya / S. Gilbert – M.: «Mir», 1995. - T. 3. – 352 s./
3. Lyons A.J. Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma / A.J. Lyons, J. Jones // Int J Oral Maxillofac Surg. – 2007. –V. 36. – P. 671-679.
4. Hynes R.O. Integrins: versatility, modulation, and signalling in cell adhesion / R.O. Hynes // Cell. – 1992. – V. 69. – P. 11-25.
5. Gogali A. Integrin receptors in primary lung cancer / A. Gogali, K. Charalabopoulos, S. Constantopoulos // Exp Oncol. – 2004. – V. 26. – P. 106-110.
6. Mousa S.A. Cell adhesion molecules: potential therapeutic and diagnostic implications / S.A. Mousa // Mol Biotechnol. – 2008. – V. 38. – P. 33-40.
7. Cell adhesion molecules / P.T. Cagle, T.C. Allen, [et al.] // Basic Concepts of Molecular Pathology, Molecular Pathology Library 2. - Springer Science + Business Media. – USA, 2009. – P.19-28.
8. Cadherin superfamily of adhesion molecules in primary lung cancer / K. Charalabopoulos, A. Gogali, O.K. Kostoula, [et al.] // Exp Oncol. - 2004. – V. 26. – P. 256-260.
9. Takeichi M. Cadherin cell adhesion receptors as morphogenetic regulator / M. Takeichi // Science. – 1991. – V. 251. – P. 1451-1459.
10. Kemler R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion / R. Kemler // Trends Genet. – 1993. – V. 9. – P. 317-321.
11. Ozawa M. The cytoplasmic domain of the cell adhesion molecule uvamorulin associates with three independent proteins structurally related in different species / M. Ozawa, H. Baribault, R. Kemler // EMBO J. - 1989 – V. 8. – P. 1711-1717.
12. Identification of a neural α -catenin as a key regulator of cadherin function and multicellular organization / S. Hirano, N. Kinoto, Y. Shimoyama, [et al.] // Cell. – 1992. – V. 70. – P. 293-301.
13. Molecular cloning and expression of murine vascular endothelial cadherin in early stage development of cardiovascular system / G. Breier, F. Breviario, L. Caveda, [et al.] // Blood. – 1996. – V. 87. – P. 630-641.
14. Selectins potential pharmacological targets / C. Kneuer, C. Ehrhardt, M.W. Radomski, [et al.] // Drug Discov Today. – 2006. – V. 11. – P. 1034-1040.
15. Petruzzelli L. Structure and function of cell adhesion molecules / L. Petruzzelli, M. Takami, H.D. Humes // Am J Med. – 1999. – V. 106. – P. 467-476.
16. Carlos T.M. Leukocyte-endothelial adhesion molecules / T.M. Carlos, J.M. Harlan // Blood. – 1994. – V. 84. – P. 2068-2101.
17. Springer T. Adhesion receptors of the immune system / T. Springer // Nature. – 1990. – V. 346. – P. 425-434.
18. Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins / A.E. Aplin, A. Howe, S.K. Alahari, [et al.] // Pharmacol Rev. – 1998. – V. 50. – P. 197-263.
19. Signal transduction by cell adhesion receptors / C. Rosales, V. O’Brian, L. Kornberg, [et al.] // Biochim Biophys Acta. – 1995. – V. 1242. – P. 77-98.
20. Nair K.S. Expression of cell adhesion molecules in oesophageal carcinoma and its prognostic value / K.S. Nair, R. Naidoo, R. Chetty // J Clin Pathol. – 2005. – V. 58. – P. 343–351.
21. Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition / K. Miyake, C.B. Underhill, J. Lesley, [et al.] // J. Exp. Med.- 1990. – V. 172. – P. 69-75.
22. Curtis A. S. G. Substrate hydroxylation and cell adhesion / A.S.G. Curtis, J.V. Forrester, P. Clark // J. Cell Sci. – 1998. – V. 86. – P. 9-24.
23. Mrksich M. A surface chemistry approach to studying cell adhesion / M. Mrksich // Chem. Soc. Rev. – 2000. – V. 29. – P. 267-273.
24. Increased adhesion of erythrocytes to components of the extracellular matrix: isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin / C.A. Hillery, M.C. Du, R.R. Montgomery, [et al.] // J. Blood. – 1996. – V. 87, № 11. – P. 4879-4886.
25. Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures / R. Hoover, R. Rubin, G. Wise, [et al.] // J. Blood. – 1979. – V. 54, № 4. – P. 872-876.
26. Walther B.T. A quantitative assay for intercellular adhesion / B.T. Walther, R. Ohman, S. Roseman // Proc Nat Acad Sci. USA. – 1973. – V. 70. – P. 1569.
27. Bell G. Models for the specific adhesion of cells to cells / G. Bell // Science. –1978. - V. 200. – P. 618-627.
28. Rutishnauser U. Neural cell adhesion between spinal cord molecule mediates initial interactions neurons and muscle cells in culture / U. Rutishnauser, M. Grumet, G.M. Edelman // J. Cell Biol. – 1983. – V. 97. – P. 145-152.
29. Takeichi M. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis / M. Takeichi // Development. – 1988. – V. 102. – P. 639-655.
30. Granger D.N. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion / D.N. Granger, P. Kubes // J. Leukocyte Biol. – 1994. – V. 55. – P. 639-655.
31. An Y.H. Mechanisms of bacterial adhesion and pathogenesis of implant and tissue infection / Y.H. An, R.B. Dickinson, R.J. Doyle // Handbook of bacterial adhesion: principles, methods and applications.-Human Press, Totowa. – 2000. – P. 1-27.
32. Dubreuil J.D. Helicobacter pylori interaction with host serum and extracellular matrix proteins: potential role in the infectious process / J.D. Dubreuil, G. Del Giudice, R. Rappuoli // Microbiol. Mol. Biol. Rev. - 2002. - V. 66, № 4. - P. 617-629.
33. Dunne W.M. Bacterial adhesion: seen any good biofilms lately? / W.M. Dunne // Clin. Microbiol. Rev. – 2002. – V.15, № 8. – P. 155-166.
34. Дмитриева Н.Ф. Липотейхоевые и тейхоевые кислоты патогенных стрептококков: структура, функции, роль во взаимодействии возбудителя с макроорганизмом / Н.Ф. Дмитриева, Ю.М. Тимофеев, Н.И. Брико // Журн. Микробиологии, епидемологии и иммунобиологии. – 2007. – № 6. – С. 100-107. /Dmitriyeva N.F. Lipoteykhoyevye i teykhoyevye kisloty patogennykh streptokokkov: struktura, funktsii, rol vo vzaimodeystvii vozbuditelja s makroorganizmom / N.F. Dmitriyeva, Yu.M. Timofeyev, N.I. Briko // Zhurn. Mikrobiologii, epidemologii i immunobiologii. – 2007. – № 6. – S. 100-107./
35. Jones G.W. Proteinaceous bacterial adhesions and their receptors / G.W. Jones, R.E. Isaacson // Crit. Rev. Microbiol. – 1983. – V. 10. – P. 29-260.
36. Plotkin B.J. Adherence of Bordetella bronchisseptica to hamster lung fibroblasts / B.J. Plotkin, D.A. Bevis // Infect Immun. – 1984. – V. 46, № 11. – P. 697-702.
37. Поспелова С.В. Изучение адгезивных свойств микроорганизмов, выделенных от больных с патологией гепатобиллиарной системы / С.В. Поспелова, Т.И. Карпунина, Н.А. Зубарева // Пермский мед. журнал. - 1998. - Т. 15, №3. - С. 22-25. /Pospelova S.V. Izucheniye adgezivnyh svoystv mikroorganizmov, vydelennyh ot bolnyh s patologiyey gepatobilliarnoy sistemy / S.V. Pospelova, T.I. Karpunina, N.A. Zubareva // Permskiy med. zhurnal. - 1998. - T. 15, №3. - S. 22-25./
38. Кlemm P. Bacterial adhesions: function and structure / P. Кlemm, M.A. Schembri // Int. J. Med. Microbiol. - 2000. – V. 290. – P. 27-35.
39. Иванова В.В. Закономерности взаимоотношений макроорганизма и возбудителей инфекционных болезней у детей / В.В. Иванова, Е.А. Корнева // Вестник РАМН. – 2000. – №11. – С. 35-40. /Ivanova V.V. Zakonomernosti vzaimootnosheniy makroorganizma i vozbuditeley infektsionnyh bolezney u detey / V.V. Ivanova, Ye.A. Korneva // Vestnik RAMN. - 2000. – №11. – S. 35-40./
40. Мавзютов А.Р. Факторы патогенности оппортунистических ентеробактерий и их роль в развитии диареи /А.Р Мавзютов., В.М. Бондаренко, Н.Ю. Жеребцова // Журн. Микробиол. – 2007. – №1. – С. 89-97. /Mavzyutov A.R. Faktory patogennosti opportunisticheskih enterobakterij i ih rol’ v razvitii diarei / A.R Mavzyutov., V.M. Bondarenko, N.Yu. Zherebtsova // Zhurn. Mikrobiol. – 2007. – № 1. – S. 89-97./
Cited
How to Cite
Anikeeva, M. O., & Gordiyenko, O. I. (1). Cell adhesion: types, mechanisms, the role in functioning of living systems. Biophysical Bulletin, 1(28). Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/2501
Section
Cell biophysics
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