Human erythrocyte membrane permeability for nonelectrolytes - series of amides
Keywords:
erythrocyte membrane, permeability, amides
Abstract
Permeability coefficients for human erythrocyte membranes for a series of amides have been determined. When molecular diameter is greater than 4Å a significant decrease in aqueous permeability has been shown. Permeability coefficients of erythrocytes incubated with pCMBS which is known as a protein channel blocker, rise with a distribution coefficient increase between hydrophilic and hydrophobic phases for the series of amides with the correlation coefficient of 0.94. The results obtained give evidence that the substances investigated permeate erythrocyte membrane by two passes: through aqueous protein channels and directly through lipid phase.
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References
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Goldstein DA, Solomon AK. Determination of equivalent pore radius for human red cells by osmotic pressure measurement. J. Gen. Physiol. 1960;44:1-17.
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Toon MR, Solomon AK. Transport parameters in the human red cell membrane: solute-membrane interaction of hydrophilic alconols and their effect on permeation. BBA. 1990;1022:57-71.
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Solomon AK, Gary-Bobo CM. Aqueous pores in lipid bilayers and red cell membranes. BBA. 1972;225:1019-21.
DeKniijff B, Demel RA. Polyene antibiotic sterol interactions in membranes of Acholiplasma laidlawwii cells and lecithin liposomes. BBA. 1974;339:57-70.
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Macey RI, Farmer REL. Inhibition of water and solute permeability in human red cells. BBA. 1970;211:104-6.
Brown PA, Feinstein MB, Sha’afi RI. Membrane proteins related to water transport in human erythrocytes. Nature. 1975;254:523-5.
Naccache P, Feinstein MB. Effect of pCMBS on water transfer across biological membranes. J.Gen.Physiol. 1974;84:449-56.
Sha’afi RI, Feinstein MB. Membrane water channels and SH-groups. Advances in experimental medicine and biology. 1977;84:67-80.
Ojcius DM, Solomon AK. Sites of p-chloromercuribenzene sulfonate inhibition of red cell urca and water transport. BBA. 1988;942:73-82.
Knauf PA. Erythrocyte anion exchange and the band 3 protein: Transport kinetics and molecular structure. Current topics in membrane transport. 1979;12:249-363.
Rao A. Disposition of the band 3 polypeptide in the human erythrocyte membrane. J. Biol. Chem. 1979;254:3503-11.
Gordienko EA, Gordienko YuE, Gordienko OI. The physico-mathematical theory of human erythrocyte hypotonic hemolysis phenomenon. Cryo Letters. 2003;4:229-44.
Toon MR, Solomon AK. Transport parameters in human red cell membrane:solute-membrane I nteractions of amides and ureas. BBA. 1991;1063:179-90.
Finkelstein A. Wqater and nonelectrolyte permeability of lipid bilayer membranes. J. Gen. Physiol. 1976;70:127-45.
Goldstein DA, Solomon AK. Determination of equivalent pore radius for human red cells by osmotic pressure measurement. J. Gen. Physiol. 1960;44:1-17.
Barton TC, Brown DAJ. Water permeability of the fetal erythrocyte. J. Gen. Physiol. 1964;47:839-49.
Solomon AK. Characterization of biological membranes by equivalent pores. J. Gen. Physiol. 1968;51:335-64.
Toon MR, Solomon AK. Transport parameters in the human red cell membrane: solute-membrane interaction of hydrophilic alconols and their effect on permeation. BBA. 1990;1022:57-71.
Holz R, Finkelstein A. The water and nonelectrolyte permeability induced in thin lipid membrances by the polyene antibiotocs nystatin and amphotericin B. J. Gen. Physiol. 1970;56:125-45.
Solomon AK, Gary-Bobo CM. Aqueous pores in lipid bilayers and red cell membranes. BBA. 1972;225:1019-21.
DeKniijff B, Demel RA. Polyene antibiotic sterol interactions in membranes of Acholiplasma laidlawwii cells and lecithin liposomes. BBA. 1974;339:57-70.
Solomon AK. The aqueous pore in red cell membrane: band 3 as a channel for anions, cations, nonelectrolytes and water. Biomembranes and cell function. Ann. N-Y Acad. Sci. 1983;414:97-124.
Macey RI, Farmer REL. Inhibition of water and solute permeability in human red cells. BBA. 1970;211:104-6.
Brown PA, Feinstein MB, Sha’afi RI. Membrane proteins related to water transport in human erythrocytes. Nature. 1975;254:523-5.
Naccache P, Feinstein MB. Effect of pCMBS on water transfer across biological membranes. J.Gen.Physiol. 1974;84:449-56.
Sha’afi RI, Feinstein MB. Membrane water channels and SH-groups. Advances in experimental medicine and biology. 1977;84:67-80.
Ojcius DM, Solomon AK. Sites of p-chloromercuribenzene sulfonate inhibition of red cell urca and water transport. BBA. 1988;942:73-82.
Knauf PA. Erythrocyte anion exchange and the band 3 protein: Transport kinetics and molecular structure. Current topics in membrane transport. 1979;12:249-363.
Rao A. Disposition of the band 3 polypeptide in the human erythrocyte membrane. J. Biol. Chem. 1979;254:3503-11.
Gordienko EA, Gordienko YuE, Gordienko OI. The physico-mathematical theory of human erythrocyte hypotonic hemolysis phenomenon. Cryo Letters. 2003;4:229-44.
Toon MR, Solomon AK. Transport parameters in human red cell membrane:solute-membrane I nteractions of amides and ureas. BBA. 1991;1063:179-90.
Finkelstein A. Wqater and nonelectrolyte permeability of lipid bilayer membranes. J. Gen. Physiol. 1976;70:127-45.
Published
2019-04-12
Cited
How to Cite
Gordiyenko, O. I., & Linnik, T. P. (2019). Human erythrocyte membrane permeability for nonelectrolytes - series of amides. Biophysical Bulletin, 1(12), 92-96. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/13032
Section
Cell biophysics
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