Interactions of Amyloid Fibrils with Functional Proteins: Modulating Effect of Polyphenols
Abstract
The elucidation of interactions between functional proteins and amyloid fibrils is crucial for understanding the molecular basis of amyloid diseases, which are characterized by protein misfolding and aggregation. Polyphenols, due to their diverse biological properties, have garnered attention for their potential to modulate these protein-fibril interactions, thereby influencing disease progression and offering therapeutic possibilities. In this study, we investigated the effects of quercetin and its binary combinations with other polyphenols on the binding affinity between cytochrome c, in both its reduced and oxidized forms, and amyloid fibrils of insulin and apolipoprotein A-I. Our results demonstrate that quercetin complexation with cytochrome c decreases the binding affinity of insulin fibrils for both forms of the protein, while increasing the affinity for apolipoprotein A-I fibrils. This modulation was attributed to competitive or allosteric effects exerted by quercetin on cytochrome c. Additionally, while binary combinations of quercetin with other polyphenols did not reduce the affinity of insulin fibrils for oxidized cytochrome c, they did decrease the affinity in the case of reduced counterpart. These findings highlight the selective and significant impact of polyphenolic compounds on the interactions between amyloid fibrils and functional proteins, suggesting potential pathways for therapeutic intervention in amyloid-related disorders.
Downloads
References
E. Chatani, K. Yuzu, Y. Ohhashi, and Y. Goto, Int. J. Mol. Sci. 22, 4349 (2021). https://doi.org/10.3390/ijms22094349
A. Buell, Chem. Sci. 12, 10177 (2022). https://doi.org/10.1039/D1SC06782F
D. Li, and C. Liu, Biochemistry 59, 639 (2020). https://doi.org/10.1021/acs.biochem.9b01069
H. Koike, and M. Katsuno, Molecules 26, 4611 (2021). https://doi.org/10.3390/molecules26154611
H. Xie, and C. Guo, Front. Mol. Biosci. 7, 629520 (2021). https://doi.org/10.3389/fmolb.2020.629520
P. Bhosale, S. Ha, P. Vetrivel, H. Kim, S. Kim, and G. Kim, Transl. Cancer Res. 9, 7619 (2020). https://doi.org/10.21037/tcr-20-2359
A. Rana, M. Samtiya, T. Dhewa, V. Mishra, and R. Aluko, J. Food. Chem. 46, e14264 (2022). https://doi.org/10.1111/jfbc.14264
Y. Nian, Y. Zhang, C. Ruan, and B. Hu, Curr. Opin. Food Sci. 43, 99 (2022). https://doi.org/10.1016/j.cofs.2021.11.005
H. Kobayashi, M. Murata, S. Kawanishi, and S. Oikawa, Int. J. Mol. Sci. 21, 3561 (2020). https://doi.org/10.3390/ijms21103561
Y. Yan, H. Tao, J. He, and S-Y. Huang, Nat. Protoc. 15, 1829–1852 (2020). https://doi.org/10.1038/s41596-020-0312-x
D. D. Schneidman-Duhovny, Y. Inbar, R. Nussimov, and H. Wolfson, Nucl. Acid Res. 33, W363 (2005). https://doi.org/10.1093/nar/gki481
Z. Zhou, T. Arroum, X. Luo, R. Kang, Y. Lee, D. Tang, M. Hüttemann, and X. Song, Cell Death Differ. 31, 387 (2024). https://doi.org/10.1038/s41418-024-01284-8
G. Perez-Mejias, A. Diaz-Quintana, A. Guerra-Castellano, I. Diaz-Moreno, and M. De la Rosa, Coord. Chem. Rev. 450, 214233 (2022). https://doi.org/10.1016/j.ccr.2021.214233
S. Watson, G. McStay, Int. J. Mol. Sci. 21, 7254 (2020). https://doi.org/10.3390/ijms21197254
A. Bigi, R. Cascella, F. Chiti, C. Cecchi, Bioessays 44, e2200086 (2022). https://doi.org/10.1002/bies.202200086
Copyright (c) 2024 Valeriya Trusova, Uliana Tarabara, Galyna Gorbenko
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
