Структура і функції ламінів: норма і патологія
Анотація
Ламіни – це білки, що належать до класу проміжних філаментів і формують «ядерний цитоскелет» – ламіну. В огляді наведені сучасні уявлення про структуру та функції ламінів в нормі та патології. Найбільшу увагу приділено ламіну А, як більш важливому з точки зору розвитку патологій і різноманітності функцій. Особливе місце надано молекулярним механізмам патологій, які виникають в результаті мутацій в генах ламінових білків, а також ролі ламнів у функціонуванні та диференціюванні стовбурових клітин.
Завантаження
Посилання
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