Human erythrocyte membrane permeability for nonelectrolytes - series of amides

  • O. I. Gordiyenko Institute for Problems of Cryobiology and Cryomedicine of NAS of Ukraine
  • T. P. Linnik Institute for Problems of Cryobiology and Cryomedicine of NAS of Ukraine
Keywords: erythrocyte membrane, permeability, amides

Abstract

Permeability coefficients for human erythrocyte membranes for a series of amides have been determined. When molecular diameter is greater than 4Å a significant decrease in aqueous permeability has been shown. Permeability coefficients of erythrocytes incubated with pCMBS which is known as a protein channel blocker, rise with a distribution coefficient increase between hydrophilic and hydrophobic phases for the series of amides with the correlation coefficient of 0.94. The results obtained give evidence that the substances investigated permeate erythrocyte membrane by two passes: through aqueous protein channels and directly through lipid phase.

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Author Biographies

O. I. Gordiyenko, Institute for Problems of Cryobiology and Cryomedicine of NAS of Ukraine

23 Pereyaslivska St., Kharkiv 61015, Ukraine

T. P. Linnik, Institute for Problems of Cryobiology and Cryomedicine of NAS of Ukraine

23 Pereyaslivska St., Kharkiv 61015, Ukraine

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Published
2019-04-12
Cited
How to Cite
Gordiyenko, O. I., & Linnik, T. P. (2019). Human erythrocyte membrane permeability for nonelectrolytes - series of amides. Biophysical Bulletin, 1(12), 92-96. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/13032