Veterinary Medicinal Products to Treat Varroosis on the Ukrainian Market in the Context of Risk Factors Analysis for Honey Bees
Keywords:
honeybee, Apis mellifera Linnaeus, 1758, varroosis, veterinary medicinal product, active substance
Abstract
Purpose. To collect information on available on the Ukrainian market veterinary medicinal products to treat honey bee varroosis caused by Varroa destructor Anderson and Trueman, 2000; to systematize the information and compile the list of the veterinary medicinal products taking into account the content of active substances, dosage form and producer.
Methods. Analysis of the information obtained in 2015–2020 by surveying beekeepers, direct communication with them, browsing Internet resources, visiting veterinary pharmacies; creation of an information database of anti-Varroa medicinal products.
Results. As for September 2020, at least 136 items of veterinary medicinal products to treat varroosis are available on the market in Ukraine, of which 79 are imported. They contain ten active substances (amitraz – in
37 products, fluvalinate – 30, flumethrin – 12, bromopropylate – 5, coumaphos – 2, acrinatrin – 1, thymol – 14, formic acid – 6, lactic acid – 6, oxalic acid – 9), vegetable essential oils and other substances. However, as for February 2020, only 17 anti-Varroa products have been included into the State Register of Veterinary Medicinal Products Permitted for Use in Ukraine. Analogs with the same concentration of the same active substance from different producers have been identified; drugs with the same name but different origins, differing both in the concentration of the active substance and in the dosage form; numerous technical errors in the indication of initial concentrations on the sites of online stores, as well as other risks associated with the dishonesty of sellers.
Conclusions. The obtained results stress the need to strengthen control over the market of veterinary medicaments to treat honey bee varroosis in Ukraine.
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References
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Steinhauer, N., Kulhanek, K., Antúnez, K., Human, H., Chantawannakul, P. & Chauzat, M. P. (2018). Drivers of colony losses. Current opinion in insect science, 26, 142–148. Retrieved from https://www.sciencedirect.com/science/article/abs/pii/S2214574517302080
Van Der Zee, R., Gray, A., Pisa, L., & De Rijk, T. (2015). An observational study of honey bee colony winter losses and their association with Varroa destructor, neonicotinoids and other risk factors. PloS one, 10(7), e0131611. Retrieved from https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131611
Efimenko, T.M., Galatyuk, O.E., Kovalenko L.M. (2017). A new way to use organic acids to kill Varroa mites. Apiary, (11), 15–17. (in Ukrainian).
Sadovnikova, E.F., Gisko, V.N. & Pankiv, E.M. (2019). Varroosis of bees: recommendations. Vitebsk: VGAVM. (in Russian).
Tlak Gajger, I., Svečnjak, L., Bubalo, D. & Žorat, T. (2020). Control of Varroa destructor Mite Infestations at Experimental Apiaries Situated in Croatia. Diversity, 12(1), 12. Retrieved from https://www.mdpi.com/1424-2818/12/1/12
Gregorc, A. & Sampson, B. (2019). Diagnosis of Varroa Mite (Varroa destructor) and Sustainable Control in Honey Bee (Apis mellifera) Colonies—A Review. Diversity, 11(12), 243. Retrieved from https://www.mdpi.com/1424-2818/11/12/243
Rinkevich, F.D. (2020). Detection of amitraz resistance and reduced treatment efficacy in the Varroa Mite, Varroa destructor, within commercial beekeeping operations. PloS one, 15(1), e0227264. Retrieved from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227264
Nazarenko O.S. (2020) Varroosis of honey bees (distribution, diagnosis and treatment). PhD Thesis, Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Lviv. (in Ukrainian).
Kamler, M., Nesvorna, M., Stara, J., Erban, T. & Hubert, J. (2016). Comparison of tau-fluvalinate, acrinathrin, and amitraz effects on susceptible and resistant populations of Varroa destructor in a vial test. Experimental and Applied Acarology, 69(1), 1–9. Retrieved from https://link.springer.com/article/10.1007/s10493-016-0023-8
González-Cabrera, J., Bumann, H., Rodríguez-Vargas, S., Kennedy, P.J., Krieger, K., Altreuther, G., Hertel, A., Hertlein, G., Nauen, R. & Williamson, M.S. (2018). A single mutation is driving resistance to pyrethroids in European populations of the parasitic mite, Varroa destructor. Journal of Pest Science, 91(3), 1137–1144. Retrieved from https://link.springer.com/article/10.1007/s10340-018-0968-y
Stara, J., Pekar, S., Nesvorna, M., Kamler, M., Doskocil, I. & Hubert, J. (2019). Spatio-temporal dynamics of Varroa destructor resistance to tau‐fluvalinate in Czechia, associated with L925V sodium channel point mutation. Pest management science, 75(5), 1287–1294. Retrieved from https://onlinelibrary.wiley.com/doi/full/10.1002/ps.5242
Sanin, Yu.K. (2017). The current state of the problem of controlling varroosis of bees. Energy and Automation, (2), 146–152. (in Ukrainian).
Evstafieva, V.O. & Nazarenko, O.S. (2020). Economic substantiation of acaricidal products use for control-ling varroasis of honey bees. Scientific and practical conference of the academic staff of Poltava State Agrarian Academy, April 22–23, 2020, 357-358. (in Ukrainian).
Kaipkulov, R.N. (2017). Production of medicinal products for honey bees in the countries of near and far abroad. One World - One Health: VII International Veterinary Congress. (April 19-21, 2017, Ufa). Ufa: Congress Hall. 2017. Retrieved September 12, 2020 from http://zhukov-vet.ru/stati/vii-mezhdunarodnyij-veterinarnyij-kongress-ufa-2017/%C2%ABbolezni-pchel%C2%BB.html (in Russian).
Kisil, D.O. & Kisil, D.A. (2018). Determination of veterinary and sanitary assessment of honey and its level of toxicity after treatment with the "Apichels" product against bee varroasis and comparative assessment of its safety in comparison with other veterinary products. Bulletin of Sumy National Agrarian University. Veterinary Medicine, 11 (43), 66–70. (in Ukrainian).
Zikic, B., Aleksic, N., Ristanic, M., Glavinic, U., Vejnovic, B., Krnjaic, I. & Stanimirovic, Z. (2020). Anti-Varroa Efficiency of Coumaphos and Its Influence on Oxidative Stress and Survival of Honey Bees. Acta Veterinaria, 70(3), 355–373. Retrieved from https://content.sciendo.com/view/journals/acve/70/3/article-p355.xml
Brodschneider, R., Gray, A., Adjlane, N., Ballis, A., Brusbardis, V., Charrière, J.-D., Chlebo, R., Coffey, M. F., Dahle, B., de Graaf, D.C., Dražić, M. M., Evans, G., Fedoriak, M., Forsythe, I. ,Gregorc, A., Grzęda, U., Hetzroni, A.,Kauko, L.,Kristiansen, P., Martikkala, M., Martín-Hernández, R. , Medina-Flores, C. A., Mutinelli, F., Raudmets, A., Ryzhikov, V. A., Simon-Delso, N., Stevanovic, J., Uzunov, A., Vejsnæs, F., Wöhl, S., Zammit-Mangion, M. & Danihlík, J. (2018) Multi-country loss rates of honey bee colonies during winter 2016/17 from the COLOSS survey. Journal of Apicultural Research, 57 (3), 452–457. https://doi.org/10.1080/00218839.2018.1460911
Gray, A., Brodschneider, R., Adjlane N., Ballis, A., Brusbardis, V., Charrière, J.-D.l., Chlebo, R., Coffey, M. F., Cornelissen, B., Amaro da Costa, C., Csáki, T., Dahle, B., Danihlík, J., Dražić, M. M., Evans, G., Fedoriak, M., Forsythe, I. , de Graaf, D., Gregorc, A., Johannesen, J., Kauko, L.,Kristiansen, P., Martikkala, M., Martín-Hernández, R. , Medina-Flores, C.A., Mutinelli, F., Patalano, S., Petrov, P., Raudmets, A., Ryzhikov, V. A., Simon-Delso, N., Stevanovic, J., Topolska, G., Uzunov, A., Vejsnæs, F., Williams, A., Zammit-Mangion, M. & Soroker, V. (2019). Loss rates of honey bee colonies during winter 2017/18 in 36 countries participating in the COLOSS survey, including effects of forage sources, Journal of Apicultural Research, 58 (4), 479–485. https://doi.org/10.1080/00218839.2019.1615661
Gray, A., Adjlane, N., Arab, A., Ballis, A., Brusbardis, V., Charrière, J.D. Chlebo, R., Coffey, M. F., Cornelissen, B., Amaro da Costa C., Dahle, B., Danihlík, J., Dražić, M. M., Evans, G., Fedoriak, M., Forsythe, I. , Gajda, A., de Graaf, D., Gregorc, A., Ilieva, I., Johannesen, J., Kauko, L., Kristiansen, P., Martikkala, M., Martín-Hernández, R., Medina-Flores, C.A., Mutinelli, F., Patalano, S., Raudmets, A., San Martin, G., Soroker, V., Stevanovic, J., Uzunov, A., Vejsnæs, F., Williams, A., Zammit-Mangion, M. & Brodschneide, R. (2020). Honey bee colony winter loss rates for 35 countries participating in the COLOSS survey for winter 2018–2019, and the effects of a new queen on the risk of colony winter loss. Journal of Apicultural Research, 59(5), 744-751. Retrieved from https://www.tandfonline.com/doi/full/10.1080/00218839.2020.1797272
Fedoriak, M., Tymochko, L., Kulmanov, O., Rudenko, S., Deli, O., Podobivskyi, S., Melnychenko, G., Brodschneider, R. & Volkov, R. (2018). Honey bee (Apis mellifera L.) colony losses in ukraine after the winter of 2016-2017 within the international monitoring. Scientific Bulletin of Chernivtsi University Biological Systems,. 10 (1), 37–46. Retrieved from http://biosystems-journal.chnu.edu.ua/index.php/BioSystems/article/view/3 (in Ukrainian).
Fedoriak, M.M., Tymochko, L.I., Kulmanov, O.M., Shkrobanets, O.O., Zhuk, A.V., Dron, Yu.S., Deli O.F., Podobivskiy, S.S., Melnychenko, G.M., Leheta, U.V. & Kholivchuk, A. (2019). Results of annual honey bee colony losses surveyin ukraine: winter 2017-2018. Scientific Herald of Chernivtsi University. Biology (Biological Systems), 11 (1), 60-70. Retrieved from http://biosystems-journal.chnu.edu.ua/index.php/BioSystems/article/view/340 (in Ukrainian).
On adoption of the Instruction on prevention and elimination of diseases and poisonings of bees. Order of the Chief State Inspector of Veterinary Medicine of Ukraine. Order, Instruction dated 30.01.2001 № 9. Retrieved October 3, 2020, from https://zakon.rada.gov.ua/laws/show/z0131-01#Text (in Ukrainian).
Register of veterinary products, feed additives, premixes and prepared feeds. Retrieved October 3, 2020, from https://data.gov.ua/dataset/8f3e00b2-16e8-4b30-af7d-b9212837b0a6
Kovalenko, V.L. & Romanenko, L.I. (2015). Veterinary products for the prevention and treatment of infectious diseases of bees. Beekeeping of Ukraine, (1), 41–46. (in Ukrainian).
Locke, B. (2016). Natural Varroa mite-surviving Apis mellifera honeybee populations. Apidologie, 47(3), 467–482. Retrieved from https://link.springer.com/article/10.1007/s13592-015-0412-8
Steinhauer, N., Kulhanek, K., Antúnez, K., Human, H., Chantawannakul, P. & Chauzat, M. P. (2018). Drivers of colony losses. Current opinion in insect science, 26, 142–148. Retrieved from https://www.sciencedirect.com/science/article/abs/pii/S2214574517302080
Van Der Zee, R., Gray, A., Pisa, L., & De Rijk, T. (2015). An observational study of honey bee colony winter losses and their association with Varroa destructor, neonicotinoids and other risk factors. PloS one, 10(7), e0131611. Retrieved from https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131611
Efimenko, T.M., Galatyuk, O.E., Kovalenko L.M. (2017). A new way to use organic acids to kill Varroa mites. Apiary, (11), 15–17. (in Ukrainian).
Sadovnikova, E.F., Gisko, V.N. & Pankiv, E.M. (2019). Varroosis of bees: recommendations. Vitebsk: VGAVM. (in Russian).
Tlak Gajger, I., Svečnjak, L., Bubalo, D. & Žorat, T. (2020). Control of Varroa destructor Mite Infestations at Experimental Apiaries Situated in Croatia. Diversity, 12(1), 12. Retrieved from https://www.mdpi.com/1424-2818/12/1/12
Gregorc, A. & Sampson, B. (2019). Diagnosis of Varroa Mite (Varroa destructor) and Sustainable Control in Honey Bee (Apis mellifera) Colonies—A Review. Diversity, 11(12), 243. Retrieved from https://www.mdpi.com/1424-2818/11/12/243
Rinkevich, F.D. (2020). Detection of amitraz resistance and reduced treatment efficacy in the Varroa Mite, Varroa destructor, within commercial beekeeping operations. PloS one, 15(1), e0227264. Retrieved from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227264
Nazarenko O.S. (2020) Varroosis of honey bees (distribution, diagnosis and treatment). PhD Thesis, Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Lviv. (in Ukrainian).
Kamler, M., Nesvorna, M., Stara, J., Erban, T. & Hubert, J. (2016). Comparison of tau-fluvalinate, acrinathrin, and amitraz effects on susceptible and resistant populations of Varroa destructor in a vial test. Experimental and Applied Acarology, 69(1), 1–9. Retrieved from https://link.springer.com/article/10.1007/s10493-016-0023-8
González-Cabrera, J., Bumann, H., Rodríguez-Vargas, S., Kennedy, P.J., Krieger, K., Altreuther, G., Hertel, A., Hertlein, G., Nauen, R. & Williamson, M.S. (2018). A single mutation is driving resistance to pyrethroids in European populations of the parasitic mite, Varroa destructor. Journal of Pest Science, 91(3), 1137–1144. Retrieved from https://link.springer.com/article/10.1007/s10340-018-0968-y
Stara, J., Pekar, S., Nesvorna, M., Kamler, M., Doskocil, I. & Hubert, J. (2019). Spatio-temporal dynamics of Varroa destructor resistance to tau‐fluvalinate in Czechia, associated with L925V sodium channel point mutation. Pest management science, 75(5), 1287–1294. Retrieved from https://onlinelibrary.wiley.com/doi/full/10.1002/ps.5242
Sanin, Yu.K. (2017). The current state of the problem of controlling varroosis of bees. Energy and Automation, (2), 146–152. (in Ukrainian).
Evstafieva, V.O. & Nazarenko, O.S. (2020). Economic substantiation of acaricidal products use for control-ling varroasis of honey bees. Scientific and practical conference of the academic staff of Poltava State Agrarian Academy, April 22–23, 2020, 357-358. (in Ukrainian).
Kaipkulov, R.N. (2017). Production of medicinal products for honey bees in the countries of near and far abroad. One World - One Health: VII International Veterinary Congress. (April 19-21, 2017, Ufa). Ufa: Congress Hall. 2017. Retrieved September 12, 2020 from http://zhukov-vet.ru/stati/vii-mezhdunarodnyij-veterinarnyij-kongress-ufa-2017/%C2%ABbolezni-pchel%C2%BB.html (in Russian).
Kisil, D.O. & Kisil, D.A. (2018). Determination of veterinary and sanitary assessment of honey and its level of toxicity after treatment with the "Apichels" product against bee varroasis and comparative assessment of its safety in comparison with other veterinary products. Bulletin of Sumy National Agrarian University. Veterinary Medicine, 11 (43), 66–70. (in Ukrainian).
Zikic, B., Aleksic, N., Ristanic, M., Glavinic, U., Vejnovic, B., Krnjaic, I. & Stanimirovic, Z. (2020). Anti-Varroa Efficiency of Coumaphos and Its Influence on Oxidative Stress and Survival of Honey Bees. Acta Veterinaria, 70(3), 355–373. Retrieved from https://content.sciendo.com/view/journals/acve/70/3/article-p355.xml
Brodschneider, R., Gray, A., Adjlane, N., Ballis, A., Brusbardis, V., Charrière, J.-D., Chlebo, R., Coffey, M. F., Dahle, B., de Graaf, D.C., Dražić, M. M., Evans, G., Fedoriak, M., Forsythe, I. ,Gregorc, A., Grzęda, U., Hetzroni, A.,Kauko, L.,Kristiansen, P., Martikkala, M., Martín-Hernández, R. , Medina-Flores, C. A., Mutinelli, F., Raudmets, A., Ryzhikov, V. A., Simon-Delso, N., Stevanovic, J., Uzunov, A., Vejsnæs, F., Wöhl, S., Zammit-Mangion, M. & Danihlík, J. (2018) Multi-country loss rates of honey bee colonies during winter 2016/17 from the COLOSS survey. Journal of Apicultural Research, 57 (3), 452–457. https://doi.org/10.1080/00218839.2018.1460911
Gray, A., Brodschneider, R., Adjlane N., Ballis, A., Brusbardis, V., Charrière, J.-D.l., Chlebo, R., Coffey, M. F., Cornelissen, B., Amaro da Costa, C., Csáki, T., Dahle, B., Danihlík, J., Dražić, M. M., Evans, G., Fedoriak, M., Forsythe, I. , de Graaf, D., Gregorc, A., Johannesen, J., Kauko, L.,Kristiansen, P., Martikkala, M., Martín-Hernández, R. , Medina-Flores, C.A., Mutinelli, F., Patalano, S., Petrov, P., Raudmets, A., Ryzhikov, V. A., Simon-Delso, N., Stevanovic, J., Topolska, G., Uzunov, A., Vejsnæs, F., Williams, A., Zammit-Mangion, M. & Soroker, V. (2019). Loss rates of honey bee colonies during winter 2017/18 in 36 countries participating in the COLOSS survey, including effects of forage sources, Journal of Apicultural Research, 58 (4), 479–485. https://doi.org/10.1080/00218839.2019.1615661
Gray, A., Adjlane, N., Arab, A., Ballis, A., Brusbardis, V., Charrière, J.D. Chlebo, R., Coffey, M. F., Cornelissen, B., Amaro da Costa C., Dahle, B., Danihlík, J., Dražić, M. M., Evans, G., Fedoriak, M., Forsythe, I. , Gajda, A., de Graaf, D., Gregorc, A., Ilieva, I., Johannesen, J., Kauko, L., Kristiansen, P., Martikkala, M., Martín-Hernández, R., Medina-Flores, C.A., Mutinelli, F., Patalano, S., Raudmets, A., San Martin, G., Soroker, V., Stevanovic, J., Uzunov, A., Vejsnæs, F., Williams, A., Zammit-Mangion, M. & Brodschneide, R. (2020). Honey bee colony winter loss rates for 35 countries participating in the COLOSS survey for winter 2018–2019, and the effects of a new queen on the risk of colony winter loss. Journal of Apicultural Research, 59(5), 744-751. Retrieved from https://www.tandfonline.com/doi/full/10.1080/00218839.2020.1797272
Fedoriak, M., Tymochko, L., Kulmanov, O., Rudenko, S., Deli, O., Podobivskyi, S., Melnychenko, G., Brodschneider, R. & Volkov, R. (2018). Honey bee (Apis mellifera L.) colony losses in ukraine after the winter of 2016-2017 within the international monitoring. Scientific Bulletin of Chernivtsi University Biological Systems,. 10 (1), 37–46. Retrieved from http://biosystems-journal.chnu.edu.ua/index.php/BioSystems/article/view/3 (in Ukrainian).
Fedoriak, M.M., Tymochko, L.I., Kulmanov, O.M., Shkrobanets, O.O., Zhuk, A.V., Dron, Yu.S., Deli O.F., Podobivskiy, S.S., Melnychenko, G.M., Leheta, U.V. & Kholivchuk, A. (2019). Results of annual honey bee colony losses surveyin ukraine: winter 2017-2018. Scientific Herald of Chernivtsi University. Biology (Biological Systems), 11 (1), 60-70. Retrieved from http://biosystems-journal.chnu.edu.ua/index.php/BioSystems/article/view/340 (in Ukrainian).
On adoption of the Instruction on prevention and elimination of diseases and poisonings of bees. Order of the Chief State Inspector of Veterinary Medicine of Ukraine. Order, Instruction dated 30.01.2001 № 9. Retrieved October 3, 2020, from https://zakon.rada.gov.ua/laws/show/z0131-01#Text (in Ukrainian).
Register of veterinary products, feed additives, premixes and prepared feeds. Retrieved October 3, 2020, from https://data.gov.ua/dataset/8f3e00b2-16e8-4b30-af7d-b9212837b0a6
Kovalenko, V.L. & Romanenko, L.I. (2015). Veterinary products for the prevention and treatment of infectious diseases of bees. Beekeeping of Ukraine, (1), 41–46. (in Ukrainian).
Published
2020-11-26
How to Cite
Fedoriak, M. M., Fylypchuk, T. V., Zhuk, A. V., Tymchuk, K. Y., & Kholivchuk, A. M. (2020). Veterinary Medicinal Products to Treat Varroosis on the Ukrainian Market in the Context of Risk Factors Analysis for Honey Bees. Visnyk of V. N. Karazin Kharkiv National University. Series Еcоlogy, (23), 102-117. https://doi.org/10.26565/1992-4259-2020-23-09
Section
Biological Research
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