Investigation of binding of antibiotic norfloxacin with DNA in the presence of aromatic biologically-active compounds

  • K. A. Rybakova Sevastopol National Technical University
  • M. P. Evstigneev Sevastopol National Technical University
Keywords: quinolone antibiotics, combination therapy, hetero-association, complexation, competitive binding, protector mechanism, interceptor mechanism

Abstract

A process of competitive binding of antibiotic Norfloxacin with DNA in the presence of antitumor antibiotics Daunomycin, Nogalamycin, Novantrone, and Actinomycin D, Caffeine and aromatic vitamins Flavin-Mononucleotide (vitamin B2) and Nicotinamide (vitamin PP) has been investigated. For all combinations considered an interrelation of effectivity of protector and interceptor mechanisms is calculated, and an estimation of the relative change of biological effect is given.

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Author Biographies

K. A. Rybakova, Sevastopol National Technical University

Sevastopol-99053, Ukraine

M. P. Evstigneev, Sevastopol National Technical University

Sevastopol-99053, Ukraine

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Neault J.F., Naoui M., Manfait M., Tajmir-Riahi H.A

Published
2007-06-05
Cited
How to Cite
Rybakova, K. A., & Evstigneev, M. P. (2007). Investigation of binding of antibiotic norfloxacin with DNA in the presence of aromatic biologically-active compounds. Biophysical Bulletin, 2(19), 36-42. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/17121