The possible role of the single-chain largeness damages in the formation of lethal DNA double-chain scissions in cells exposed to X-radiation or gamma-radiation
Keywords:
double-chain scissions DNA, single-chain damages, X-radiation, gamma-radiation
Abstract
In paper we have propound the origination radiation damage that could be hardly repaired or non-repaired as a result of the transformation single-chain largeness gaps into double-chain scissions in the DNA of the irradiated cells. It became the basis for the mathematical modelling of the single-chain largeness gaps formation and theirs transformation into the double-chain scissions. By virtue of the constructed model the formulas for calculating the mean number of single-chain largeness gaps and double-chain scissions at the cell were obtained.
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References
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Gaziev AI. Povrezhdenie DNK v kletkakh pod deistviem ioniziruiushchei radiatcii. Radiatcionnaia biologiia. Radioekologiia. 1999;39(6):630-8. (in Russian)
Grodzinskii DM. Radіobіologіia. K.:Libіd4 2000. 448p. (in Ukrainian)
Moskaleva EIu, Iliushina NA. Povrezhdenie DNK pri deistvii ioniziruiushchikh izluchenii i ikh reparatciia. Itogi nauki i tekhniki. Radiatcionnaia biologiia. 1990;9:1-113. (in Russian)
Knigavko VG, Meshcheriakova OP. O vozmozhnіkh mekhanizmakh obrazovaniia dvunitevykh razryvov DNK kletok pri obluchenii ikh rentgenovskimi ili gamma-izlucheniiami. Fizika zhivogo. 2003;11(2):46-51. (in Russian)
Soifer VN. Reparatciia geneticheskikh povrezhdenii. Sorosovskii obrazovatelnіi zhurnal. 1997;8:4-13. (in Russian)
Iarygin VN. Biologiia. M.:Vysshaia shkola; 2000. 448p. (in Russian)
Spirin AS. Biosintez belka: elongatciia polipeptida i terminatciia transliatcii. Sorosovskii obrazovatelnyi zhurnal. 1999;6:4-13. (in Russian)
Published
2018-06-25
Cited
How to Cite
Knigavko, V. G., Meshcheryakova, O. P., & Radzichevckaya, E. B. (2018). The possible role of the single-chain largeness damages in the formation of lethal DNA double-chain scissions in cells exposed to X-radiation or gamma-radiation. Biophysical Bulletin, 2(13), 82-85. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/12441
Section
Biophysics of complex systems
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