Intermolecular interactions of decamethoxinum and acetylsalicylic acid in systems of various complexity levels

  • O. V. Vashchenko
  • N. A. Kasian
  • V. A. Pashynska
  • M. V. Kosevich
  • A. O. Sadchenko
  • D. N. Tishko
  • T. V. Tishko
  • V. P. Titar
  • L. N. Lisetski
Keywords: intermolecular interactions, noncovalent complexes, decamethoxinum, acetylsalicylic acid, model lipid membranes, erythrocytes

Abstract

Intermolecular interactions between decamethoxinum (DEC) and acetylsalicylic acid (ASА) have been studied in the phospholipid-containing systems of escalating complexity levels. The host media for these substances were solvents, L-α-dipalmitoylphosphatidylcholine (DPPC) membranes, and samples of human erythrocytes. Peculiar effects caused by DEC-ASА interaction have been observed in each system using appropriate techniques: (a) DEC-ASА non-covalent complexes formation in DPPC-containing systems were revealed by mass spectrometry with electrospray ionization; (b) joint DEC-ASА action on DPPC model membranes led to increasing of membrane melting temperature Tm, whereas individual drugs caused pronounced Tm decreasing, which was demonstrated by differential scanning calorimetry; (c) deceleration of DEC-induced haemolysis of erythrocytes under joint DEC-ASА application was observed by optical microscopy.

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Published
2016-07-25
Cited
How to Cite
Vashchenko, O. V., Kasian, N. A., Pashynska, V. A., Kosevich, M. V., Sadchenko, A. O., Tishko, D. N., Tishko, T. V., Titar, V. P., & Lisetski, L. N. (2016). Intermolecular interactions of decamethoxinum and acetylsalicylic acid in systems of various complexity levels. Biophysical Bulletin, 2(34), 5-15. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/4842
Section
Molecular biophysics