@article{Vashchenko_Kasian_Pashynska_Kosevich_Sadchenko_Tishko_Tishko_Titar_Lisetski_2016, title={Intermolecular interactions of decamethoxinum and acetylsalicylic acid in systems of various complexity levels}, volume={2}, url={https://periodicals.karazin.ua/biophysvisnyk/article/view/4842}, abstractNote={<p style="margin-left: 0.5cm; margin-right: 0.5cm; margin-bottom: 0cm; line-height: 100%;" lang="ru-RU" align="JUSTIFY"><span style="font-size: small;"><span lang="en-US">Intermolecular interactions between decamethoxinum (DEC) and acetylsalicylic acid (ASА) have been studied in the phospholipid-containing systems of escalating complexity levels. The host media for these substances were </span></span><span style="font-size: small;"><span lang="en-US">solvents, </span></span><span style="font-size: small;"><span lang="en-US"><em>L</em></span></span><span style="font-size: small;"><span lang="en-US">-α-dipalmitoylphosphatidylcholine (DPPC) membranes, and samples of human erythrocytes. Peculiar effects caused by DEC-ASА interaction have been observed in each system using appropriate techniques: (a) DEC</span></span><span style="font-size: small;"><span lang="uk-UA">-</span></span><span style="font-size: small;"><span lang="en-US">ASА non-covalent complexes formation in DPPC-containing systems were revealed by mass spectrometry with electrospray ionization; (b) joint DEC-ASА action on DPPC model membranes led to increasing of membrane melting temperature </span></span><span style="font-size: small;"><span lang="en-US"><em>T</em></span></span><sub><span style="font-size: small;"><span lang="en-US"><em>m</em></span></span></sub><span style="font-size: small;"><span lang="en-US">, whereas individual drugs caused pronounced </span></span><span style="font-size: small;"><span lang="en-US"><em>T</em></span></span><sub><span style="font-size: small;"><span lang="en-US"><em>m</em></span></span></sub><span style="font-size: small;"><span lang="en-US"> decreasing, which was demonstrated by differential scanning calorimetry; (c) deceleration of DEC-induced haemolysis of erythrocytes under joint DEC-ASА application was observed by optical microscopy</span></span><span style="font-size: small;"><span lang="uk-UA">.</span></span></p&gt;}, number={34}, journal={Biophysical Bulletin}, author={Vashchenko, O. V. and Kasian, N. A. and Pashynska, V. A. and Kosevich, M. V. and Sadchenko, A. O. and Tishko, D. N. and Tishko, T. V. and Titar, V. P. and Lisetski, L. N.}, year={2016}, month={Jul.}, pages={5-15} }