STABILITY OF DICATION OF DECAMETHOXINUM AS REVEALED BY SECONDARY ION MASS SPECTROMETRY

  • M. V. Kosevich B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine
  • V. A. Pashinskaya B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine
  • Z. Szilagyi Institute of Chemistry Hungarian Academy of Sciences
  • K. Vekey Institute of Chemistry Hungarian Academy of Sciences
  • V. S. Shelkovsky B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine
  • Yu. P. Blagoy B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine
Keywords: decamethoxinum, secondary ion mass spectrometry, thermal degradation

Abstract

Stability of the dication of an antimicrobial drug decamethoxinum under the influence of various physical factors was studied. Significant differences in the pathways of transformation of decamethoxinum under the influence of heating and upon long-term storage were revealed By means of the secondary ion mass spectrometry it was shown that the changes in the medicine with time upon neglect of storage rules are connected, obviously, with the deleting of chlorine counterions from the crystalline sample with preservation of the structure of the dication, while upon thermal treatment a dequaternization of the quaternary nitrogens of decamethoxinum with formation of tertiary amines takes place.

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Author Biographies

M. V. Kosevich, B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine

 47 Lenin Ave., Kharkov 310164. Ukraine

V. A. Pashinskaya, B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine

47 Lenin Ave., Kharkov 310164. Ukraine

Z. Szilagyi, Institute of Chemistry Hungarian Academy of Sciences

 Pustaszeri ut 59-67, H-1025 Budapest IL, Hungary

K. Vekey, Institute of Chemistry Hungarian Academy of Sciences

 Pustaszeri ut 59-67, H-1025 Budapest IL, Hungary

V. S. Shelkovsky, B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine

 47 Lenin Ave., Kharkov 310164. Ukraine

Yu. P. Blagoy, B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine

 47 Lenin Ave., Kharkov 310164. Ukraine

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Cited
How to Cite
Kosevich, M. V., Pashinskaya, V. A., Szilagyi, Z., Vekey, K., Shelkovsky, V. S., & Blagoy, Y. P. (1). STABILITY OF DICATION OF DECAMETHOXINUM AS REVEALED BY SECONDARY ION MASS SPECTROMETRY. Biophysical Bulletin, 2(2). Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/2444
Issue
Vol. 2 No. 2 (1998): Біофізичний вісник
Section
Molecular biophysics

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