TY - JOUR AU - Kosevich, M. V. AU - Pashinskaya, V. A. AU - Szilagyi, Z. AU - Vekey, K. AU - Shelkovsky, V. S. AU - Blagoy, Yu. P. PY - 1970/01/01 Y2 - 2024/03/29 TI - STABILITY OF DICATION OF DECAMETHOXINUM AS REVEALED BY SECONDARY ION MASS SPECTROMETRY JF - Biophysical Bulletin JA - Bioph. Bull. VL - 2 IS - 2 SE - Molecular biophysics DO - UR - https://periodicals.karazin.ua/biophysvisnyk/article/view/2444 SP - AB - Stability of the dication of an antimicrobial drug decamethoxinum under the influence of various physical factors was studied. Significant differences in the pathways of transformation of decamethoxinum under the influence of heating and upon long-term storage were revealed By means of the secondary ion mass spectrometry it was shown that the changes in the medicine with time upon neglect of storage rules are connected, obviously, with the deleting of chlorine counterions from the crystalline sample with preservation of the structure of the dication, while upon thermal treatment a dequaternization of the quaternary nitrogens of decamethoxinum with formation of tertiary amines takes place. ER -