Structure of population of Ukraine by phenylthiocarbamide sensitivity

  • О. В. Філіпцова
  • І. А. Тимошина
  • О. Ф. Чечуй
Keywords: phenylthiocarbamide; taste sensitivity; tasters/non-tasters for bitter taste; genetic marker; population of Ukraine

Abstract

The structure of the sample of population of Ukraine regarding the frequency of phenotypes, genotypes and genes, associated with the phenylthiocarbamide sensitivity, has been studied. It has been shown that in the population there are 22% of those who do not feel the taste of phenylthiocarbamide. Among males, there are a few more non-tasters than among females, however, the differences by the given sample size (n=255) are not statistically significant. The frequency of dominant and recessive allele of the phenylthiocarbamide sensitivity gene calculated on the basis of the Hardy-Weinberg equation amounted in the sample as a whole pT=0.47 and qt=0.53 respectively.

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References

Banning M. The carcinogenic and protective effects of food // Br. J. Nurs. – 2005. – Vol.14, №.20. – P. 1070–1074.

Bartoshuk L.M. Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception // Chem Senses. – 2000. – Vol.25, №.4. – P. 447–460.

Behrens M., Gunn H.C., Ramos P.C. et al. Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perception // Chem. Senses. – 2013. – Vol.38, №.6. – P.475–484.

Bernheim F., Bernheim M.L.C. The action of phenylthiocarbamide on tyrosinase // J. Biol. Chem. – 1942. – Vol.145. – P. 213–217.

Bufe B., Breslin P.A., Kuhn C. et al. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception // Curr. Biol. – 2005. – Vol.15, №4. – P.322–327.

Campbell M.C., Ranciaro A., Froment A. et al. Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa // Mol. Biol. Evol. – 2012. – Vol.29, №4. – P. 1141–1153.

Compton M.T., Chien V.H., Bollini A.M., Walker E.F. Lack of support for the inability to taste phenylthiocarbamide as an endophenotypic marker in patients with schizophrenia and their first-degree relatives // Schizophr. Res. – 2007. – Vol.95, № 1–3. – P. 65–69.

Drewnowski A., Henderson S.A., Barratt-Fornell A. Genetic taste markers and food preferences // Drug Metab. Dispos. – 2001. – Vol.29, №4, Is.2. – P. 535–538.

Fareed M., Shah A., Hussain R., Afzal M. Genetic study of phenylthiocarbamide (PTC) taste perception among six human populations of Jammu and Kashmir (India) // Egyptian Journal of Medical Human Genetics. – 2012. – Vol.13, Is.2. – P. 161–166.

Gandhi G., Kaur G., Kaur A. et al. Genetic sensitivity to phenylthiocarbamide – effect on body mass indices and DNA damage // Antrocom. Online Journal of Anthropology. – 2012. – Vol.8, №1. – P. 91–101.

Garcia-Bailo B., Toguri C., Eny K.M., El-Sohemy A. Genetic variation in taste and its influence on food selection // OMICS. – 2009. – Vol.13, №1. – P. 69–80.

Guo S.W., Reed D.R. The genetics of phenylthiocarbamide perception // Ann. Hum. Biol. – 2001. – Vol.28, №2. – P. 111–142.

Harris H., Kalmus H. The measurement of taste sensitivity to phenylthiourea (PTC) // Ann Eugen. – 1949. – Vol.15. – P. 24–31.

Hussain R., Shah A., Afzal M. Distribution of sensory taste thresholds for phenylthiocarbamide (PTC) taste ability in North Indian Muslim populations // Egyptian Journal of Medical Human Genetics. – 2013. – Vol.14, Is.4. – P. 367–373.

Igbeneghu C., Owoeye Y., Akanni E.O. Association between phenylthiocarbamide (PTC) taste perception and falciparum malaria infection in Osogbo, Southwestern Nigeria // Annual Research & Review in Biology. – 2014. – Vol.4, №14. – P. 2295–2301.

Iqbal T., Ali A., Atique S. Prevalence of taste blindness to phenylthiocarbamide in Punjab // Pak. J. Physiol. – 2006. – Vol.2, №2. – P. 35–37.

Jaiswal A. Taste sensitivity to phenylthiocarbamide (PTC) and Incidence of colour blindness among the Jats and Brahmins of District Rohtak, Haryana // Asia Pacific Journal of Social Science. – 2012. – Vol.IV, №1. – P. 79–89.

Johna S.J.S., Poura L., Boughter J.D. Phenylthiocarbamide produces conditioned taste aversions in mice // Chem. Senses. – 2005. – Vol.30, №5. – P. 377–382.

Joseph M.E. Comparison of electrogustometrically determined taste threshold and phenylthiocarbamide sensitivity between non-diabetic subjects with first degree relatives with type 2 diabetes and non-diabetic subjects without type 2 diabetic first degree relatives // PCOM Biomedical Studies Student Scholarship. – 2013. – Paper 73 (http://digitalcommons.pcom.edu/cgi/viewcontent.cgi?article=1064&context=biomed).

Krut L.H., Perrin M.J., Bronte-Stewart B. Taste perception in smokers and non-smokers // Br. Med. J. – 1961. – Vol.1 (5223). – P. 384–387.

Merritt R.B., Bierwert L.A., Slatko B. et al. Tasting phenylthiocarbamide (PTC): a new integrative genetics lab with an old flavor // The American Biology Teacher. – 2008. – Vol.70, №5. – e23–e28.

Moberg P.J., McGue C., Kanes S.J. et al. Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance // Schizophr. Res. – 2007. – Vol.90, № 1–3. – P. 221–228.

Moberg P.J., Roalf D.R., Balderston C.C. et al. Phenylthiocarbamide perception in patients with schizophrenia and first-degree family members // Am. J. Psychiatry. – 2005. – Vol.162. – P. 788–790.

Newcomb R.D., Xia M.B., Reed D.R. Heritable differences in chemosensory ability among humans // Flavour. – 2012. – Vol.1, Is.9 (doi:10.1186/2044-7248-1-9).

Olson J.M., Boehnke M., Neiswanger K. et al. Alternative genetic models for the inheritance of the phenylthiocarbamide taste deficiency // Genet. Epidemiol. – 1989. – Vol.6, №3. – P. 423–434.

Padmavathi M. A study on phenylthiocarbamide tasting in Bagatha Tribes in India // Int. Res. J. Biological Sci. – 2013. – Vol.2, №4. – P. 33–36.

Pal S.K., Sharma K., Pathak A. et al. Possible relationship between phenylthiocarbamide taste sensitivity and epilepsy // Neurol. India. – 2004. – Vol.52, №2. – P. 206–209.

Pavlovich S.А., Bezrukov V.F. Anxiety manifestations variability among youth of different phenotypical groups // The Bulletin of Vavilov Society of Geneticists and Breeders of Ukraine. – 2007. – Vol.5, No 1–2. – P. 48–55. (in Russian)

Saraswathi Y.S., Najafi M., Vineeth V.S. et al. Association of phenylthiocarbamide taste blindness trait with early onset of childhood obesity in Mysore // Journal of Paramedical Sciences (JPS). – 2011. – Vol.2, №4. – P. 6–11.

Sato T., Okada Y., Miyamoto T., Fujiyama R. Distribution of non-tasters for phenylthiocarbamide and high sensitivity to quinine hydrochloride of the non-tasters in Japanese // Chem. Senses. – 1997. – Vol.22, №5. – P. 547–551.

Shivaprasad H.S., Chaithra P.T., Kavitha P., Malini S.S. Role of phenylthiocarbamide as a genetic marker in predicting the predisposition of disease traits in humans // J. Nat. Sc. Biol. Med. – 2012. – Vol.3, Is.1. – P. 43–47.

Sourav Sen, Sabyasachi Saha, Vamsi Krishna Reddy L. et al. Sensitivity to bitter & sweet perception in relation to dental caries among 12 year old school children in Lucknow – a cross sectional study // International Journal of Oral Health Research & Review. – 2012. – Vol.1, Is.1. – P. 83–93.

Sung Yong Choi, Seung Heon Shin, Mi Kyung Ye. Taste thresholds of phenylthiocarbamide and 6-n-propylthiouracil and their correlation with TAS2R38 genotype // Rhinology. – 2010. – Vol.53, №9. – P. 547–51.

White T.L., Dishaw L.V., Sheehe P.R., Youngentob S.L. The relationship between PROP and ethanol preferences: an evaluation of 4 inbred mouse strains // Chem. Senses. – 2007. – Vol.32, №9. – P. 847–853.

Wooding S. Phenylthiocarbamide: a 75-year adventure in genetics and natural selection // Genetics. – 2006. – Vol.172, №4. – P. 2015–2023.

Wooding S., Gunn H., Ramos P. et al. Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables // Chem. Senses. – 2010. – Vol.35, №8. – P. 685–692.

Yagur V.Ye. Genetic marker “sensitivity to phenylthiocarbamide" and clinical polymorphism of rheumatoid arthritis // Medical Journal. – 2008. – No.2. – P. 95–97. (in Russian)

Yumnam Luxmi, Kapoor A.K. A study of taste sensitivity of phenylthiocarbamide (PTC) and colour blindness among the Rajputs of Dadra and Nagar Haveli // Anthropologist. – 2011. – Vol.13, №2. – P. 163–165.

Published
2014-02-25
Cited
How to Cite
Філіпцова, О. В., Тимошина, І. А., & Чечуй, О. Ф. (2014). Structure of population of Ukraine by phenylthiocarbamide sensitivity. The Journal of V.N.Karazin Kharkiv National University. Series «Biology», 21(1112), 65-71. Retrieved from https://periodicals.karazin.ua/biology/article/view/13978
Section
GENETICS