ROLE OF COMPLEX Ca2+/CALMODULIN IN SIGNAL TRANSDUCTION ABOUT MECHANICAL STRESS-STRAIN INTO CONNECTIVE TISSUES
Abstract
The investigation of chlorpromazine, EGTA and Ca2+ influence on collagen synthesis, concentration and level of collagen cross-linking in skin of 3-month rats in vitro has been done. It was obtained that the in noncalcium environment and in the presence of chlorpromazine the increasing of collagen synthesis occurs. In the hypercalcium environment the decreasing of collagen synthesis occurs. At the incubation with EGTA the sharp increasing of collagen solubility was observed. All data point to the clear dependency between complex Ca2+/calmodulin activity and collagen synthesis.
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