Endothelial function and adaptive capabilities of adolescent adolescents with arterial hypertension
Abstract
Summary. The article is devoted to the study of the state of vascular reactivity, morphofunctional parameters of the heart and adaptive capabilities in adolescents with arterial hypertension. The goal is to study the the state of endothelium-dependent vasodilation and determine the adaptive capabilities of boys with arterial hypertension without metabolic risk factors, depending on the presence of endothelial dysfunction.
The study included 22 boys with arterial hypertension aged 13-17 years, 10 of them had endothelial dysfunction on a sample with reactive hyperemia. The study included clinical examination, anthropometry, ECG, EchoCG, functional tests (Ruffier, klinoorthotest). Serum total cholesterol levels were also assessed. Statistical analysis was performed using the program s / n SPSS 17 4a 180844250981.
Results. It was found that 58.4% of boys with arterial hypertension had endothelial dysfunction without metabolic risk, which in most cases combined with reduced exercise tolerance and insufficient physical activity. In such adolescents, in comparison with peers with hypertension and normal endothelial function, higher growth, a high frequency of dolichomelia, an increase in the ejection fraction and pressure in the left atrium are noted, indicating an increase in the pumping function of the left ventricle. The frequency of registration of endothelial dysfunction was not substantially correlated with the type of vegetative support for activities in children with arterial hypertension. However, in 60% it was registered against insufficient sympathoadrenal supply - asympathicotonic and hyperdiastolic variants of the klinoorthotest.
The presence of endothelial dysfunction is recorded in more than half of adolescents with arterial hypertension. Higher ejection fraction and pressure in the left atrium during systole, which are determined in patients with arterial hypertension and insufficient vasodilation with a decrease in heart rate reflect adaptive changes in the functioning of the myocardium with a deterioration in endothelial function.
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