Features of cytokine production in different forms of Epstein-Barr virus infection

doi:10.26565/2617-409X-2018-1-12

М. М. Popov V. N. Karazin Kharkiv National University https://orcid.org/0000-0002-5759-9654
Т. I. Liadova V. N. Karazin Kharkiv National University https://orcid.org/0000-0002-9255-6019
О. G. Sorokina V. N. Karazin Kharkiv National University https://orcid.org/0000-0001-6646-544X

DOI: https://doi.org/10.26565/2617-409X-2018-1-12

Keywords: immunity, cytokines, types of immune response, EBV infection

Abstract

In article presented results of the study of basic levels of regulatory cytokines in patients with various forms of Epstein-Barr virus infection. Analysis of the dynamics of cytokine profile in patients with Epstein-Barr virus infection revealed the opposite changes studied synthesis of proinflammatory and anti-inflammatory cytokines, which was the basis for the establishment of the four types of immune response. The findings confirm the existence of cytokine imbalance with Epstein-Barr virus infection. The established types of immune responses indicate inadequate cell humoral reactivity in a long persistence of Epstein-Barr virus infection, which manifests a tendency to suppression of cell-mediated and humoral immune response enhancement mechanisms and displayed in the clinical and biochemical manifestations of the disease, and also leads to prolonged undulating course. The results of studies confirm the existence of cytokine imbalance in various forms of EBV infection. The established types of immune response indicate inadequate cellular-humoral reactivity of the organism under the conditions of long-term EBV persistence. This is manifested by a tendency to suppress cell-mediated and increased humoral mechanisms of the immune response and is displayed in the clinical and biochemical manifestations of the disease and leads to a prolonged wave-like course of the disease.
Interesting and promising are studies aimed at the medical correction of identified disorders in established types of immune response in patients with HEVE and studying the effects of the latter on the outcomes of the disease, the development of complications and activity of the process, which will be the subject of our further study.

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Author Biographies

М. М. Popov, V. N. Karazin Kharkiv National University

Svobody sq., 6, Kharkiv, 61022, Ukraine

Т. I. Liadova, V. N. Karazin Kharkiv National University

Svobody sq., 6, Kharkiv, 61022, Ukraine

О. G. Sorokina, V. N. Karazin Kharkiv National University

Svobody sq., 6, Kharkiv, 61022, Ukraine

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