Encapsulation of europium chelates into lipid vesicles
Keywords:
europium chelates, doxorubicin, liposomes, fluorescence quenching
Abstract
The partitioning of europium chelates (EC) between the aqueous and lipid phases was studied. The
possibility of coencapsulation of two anticancer drugs (doxorubicin and europium complex) into lipid
vesicles was evaluated. Partition coefficients obtained by equilibrium dialysis technique indicate that EC
can be effectively entrapped by the lipid phase of liposomes. Measurement of intrinsic fluorescence of
doxorubicin suggests that this agent is located mainly in the inner aqueous phase of liposomes. EC were
found to quench the fluorescence of Laurdan and pyrene. The effect of doxorubicin on incorporation of
europium complexes into lipid bilayer was demonstrated to depend on chemical structure of chelates.
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References
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Cited
How to Cite
E.V. Pakhomova, E. V., Kutsenko, O. K., Gorbenko, G. P., Trusova, V. M., Deligeorgiev, T., Vasilev, A., Kaloianova, S., & Lesev, N. (1). Encapsulation of europium chelates into lipid vesicles. Biophysical Bulletin, 1(26). Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/2707
Section
Cell biophysics
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