RELAXATION AND SPECTROSCOPIC MANIFESTATIONS OF HYDRATION OF POLYRIBOCYTIDYLIC ACID
Abstract
Hydration and structure state of polyribocytidylic acid (poly(rC)) have been studied in solutions and humid films. The role of water in forming different structures of poly(rC) was elucidated, hi solutions, the hydration values of single-strand (pH 4.5), double-strand (pH 7.8) and disordered (pH 3.3) forms of poly(rC) were determined with a differential EHF-dielectrometer using the measurements of dielectric permittivity at wavelength7.6 mm. In humid films, distribution of water molecules on the hydration sites for these structures has been found with IR spectroscopy. Hydration models of the single and double-strand structures of poly(rC) were developed using X-ray and these data.
KEY WORDS: polycytidylic acid, hydration, infrared spectra, millimeter region, structural transitions.
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