TERMOTROPIC CHANGES OF FIBRINOGEN CONFORMATION
Abstract
The information concerning the structural changes of fibrinogen molecule at temperatures from 4 to 52°C has been obtained by means of UV-spectroscopy and dielectric-spectroscopy methods. Besides the known conformational transition II (at about 10°C), under physiological conditions conformational transition at 18-22°C has been observed in fibrinogen. This transition might be connected with structural transition in D-domain of fibrinogen and accompanied by an increase in tryptophanyl accessibility to the solvent. Revealed conformational transition, probably, determines the character of the temperature dependence of blood platelet aggregation.
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References
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