TERMOTROPIC CHANGES OF FIBRINOGEN CONFORMATION

Authors

  • V. P. Berest Kharkov Slate University Author
  • S. V. Gatash Kharkov Slate University Author
  • Т. F. Morozova Institute for Problems ofCryobiology and Cryomedidne, National Academy of Sciences of Ukraine Author

Keywords:

fibrinogen, temperature

Abstract

The information concerning the structural changes of fibrinogen molecule at temperatures from 4 to 52°C has been obtained by means of UV-spectroscopy and dielectric-spectroscopy methods. Besides the known conformational transition II (at about 10°C), under physiological conditions conformational transition at 18-22°C has been observed in fibrinogen. This transition might be connected with structural transition in D-domain of fibrinogen and accompanied by an increase in tryptophanyl accessibility to the solvent. Revealed conformational transition, probably, determines the character of the temperature dependence of blood platelet aggregation.

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Author Biographies

  • V. P. Berest, Kharkov Slate University

    4 Svobody Sq., Kharkov 310077, Ukraine

  • S. V. Gatash, Kharkov Slate University

     4 Svobody Sq., Kharkov 310077, Ukraine

  • Т. F. Morozova, Institute for Problems ofCryobiology and Cryomedidne, National Academy of Sciences of Ukraine

    Institute for Problems ofCryobiology and Cryomedidne, National Academy of Sciences of Ukraine

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Issue

Vol. 1 No. 1 (1998): Біофізичний вісник

Section

Molecular biophysics

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How to Cite

TERMOTROPIC CHANGES OF FIBRINOGEN CONFORMATION. (2015). Biophysical Bulletin, 1(1). https://periodicals.karazin.ua/biophysvisnyk/article/view/2024

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