Ip-spectroscopic study on DNA interaction with Cd2+ ions
Keywords:
DNA, Cd2 ions, IR-spectroscopy
Abstract
The IR-spectroscopy method was used to study a DNA interaction with Cd2+ ions in aqueous solution. While interacting with metal ions, DNA with the high concentration transits into the compact structure. Association constants are determined, cooperativity of the Cd2+ ion binding is demonstrated, and nonmonotonous dependence of the binding degree (r) on the concentration of free metal ions (Cf) is ascertained. Binding isotherms are of the S-like binding to DNA molecules is highly cooperative.
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References
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Diguid JG,Bloomfield VA. Biophys J. 1995;69:2642-8.
Blagoi YuP, Galkin VL, Gladchenko GO, Kornilova SV, Sorokin VA, Shkorbatov AG. Metallokompleksy nukleinovykh kislot v rasvorakh. Kiev:Naukova Dumka; 1991. 240p. (in Russian).
Kornilova S, Hackl E, Kapinos L, Andrushchenko V, Blagoi YuP.
Acta Biochimica Polonica. 1998;45(1):107-17.
Hackl EV, Kornilova SV, Kapinos LE, Andrushchenko VV, Galkin VL, Blagoi YuP. J Mol Struct. 1997;408/409:229-32.
Sorokin VA, Valeev VA, Gladchenko GO, Sysa LV. Biophysics. 1997;42(1):111-22.
Arakawa H, Neault JE, Tajmir-Riahi HA. Biophys J. 2001;81(3):1580-7.
Andrushchenko VV, van de Sande LH, Wieser H. Vibr Spectrosc. 1999;19:341-5.
Published
2018-06-25
Cited
How to Cite
Onyshchenko, V. V. (2018). Ip-spectroscopic study on DNA interaction with Cd2+ ions. Biophysical Bulletin, 1(12), 44-48. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/12058
Section
Molecular biophysics
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