The distribution of hyaluronan-binding activity of rats brain proteins under doxorubicin effect
Abstract
Using solid phase carbohydrate-enzyme analysis the study of hyaluronan-binding activity of brain proteins has been carried out in water-soluble, membrane and extracellular fractions obtained from different brain areas of Wistar rats. Doxorubicin has led to the change of protein affinity to hyalyronate depending on the area of brain and the cellular compartment, with the most pronounced effect in water-soluble fraction of cerebellum and extracellular fraction from cerebellum and hippocampus. The use of doxorubicin simultaneously with α-ketoglutarate has led partially to approximation of hyaluronan-binding proteins activity to the values of the norm but not in all areas of rats brain.
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