The S-100b protein level changes in the different brain areas of gerbils at aging and alpha-ketoglutarate effect
Abstract
S-100b protein is often used as a marker of astrocytes, especially at brain damage (cortical, ischemic, etc.). The paper presents the dynamics of the concentration of S-100b protein in the cerebellum, thalamus and hippocampus of Mongolian gerbils to determine the reference data on the level of this protein in the brain during ontogenesis. The concentration of S-100b protein elevated in the brain to the level of adult animals at 30 days of postnatal development (increase was of almost 4 times compared to newborns animals). At aging hyperactivation of S-100b production was noted in the cerebellum and hippocampus, which may indicate the activation of calcium-dependent mechanism of astrogliosis that lead to inhibition of neurophysiological processes that are provided in these parts of the brain (the coordination of movement, learning and memory). The long-term diet with 2% of alpha-ketoglutarate for 6 months prevents overproduction of S-100b in the hippocampus in older animals.
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