THE INFLUENCE OF HEMOLYSIS ON GLUTATHIONE S-TRANSFERASE ACTIVITY IN RAT LIVER AND KIDNEY
Abstract
Tissue-specific changes of glutathione-S-transferase activity in rat liver and kidney were revealed under action of agents causing hemolysis and accumulation of heme-containing compounds in blood. Phenylhydrazine caused in vivo the decrease of glutathione-S-transferase activity that was more expressed in liver than in kidney. Glycerol model of rhabdomyolysis in the contrary caused the decrease of glutathione-S-transferase activity more expressed in kidney than in liver. Mercury chloride caused the increase of enzyme activity in both organs more expressed in kidney. The influence of total heme level in organ on the dynamics of glutathione-S-transferase activity is discussed. The conclusion is made that changes of glutathione-S-transferase activity are more expressed and prolonged in organ where hemolysis products and injected xenobiotics are metabolized and/or accumulated.
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