INTERACTION OF EUROPIUM CHELATES WITH LIPID MONOLAYERS

  • Valeriya Trusova Department of Biological and Medical Physics, V.N. Karazin Kharkov National University4 Svobody Sq., Kharkov, 61022, Ukraine https://orcid.org/0000-0002-7087-071X
  • A. Yudintsev Department of Biological and Medical Physics, V.N. Karazin Kharkov National University 4 Svobody Sq., Kharkov, 61022, Ukraine https://orcid.org/0000-0003-0333-5095
  • O. Kutsenko Department of Biological and Medical Physics, V.N. Karazin Kharkov National University4 Svobody Sq., Kharkov, 61022, Ukraine https://orcid.org/0000-0002-6670-7119
  • O. Pakhomova Department of Biological and Medical Physics, V.N. Karazin Kharkov National University 4 Svobody Sq., Kharkov, 61022, Ukraine
  • R. Volinsky Department of Biomedical Engineering and Computational Science, School of Science and Technology Aalto University, FI-00076, Espoo, Finland
  • Galyna Gorbenko Department of Biological and Medical Physics, V.N. Karazin Kharkov National University 4 Svobody Sq., Kharkov, 61022, Ukraine https://orcid.org/0000-0002-0954-5053
  • T. Deligeorgiev Departemnt of Applied Organic Chemistry, Faculty of Chemistry and Pharmacy University of Sofia, Sofia 1164, Bulgaria
  • Päivi Kinnunen Department of Biomedical Engineering and Computational Science, School of Science and Technology Aalto University, FI-00076, Espoo, Finland https://orcid.org/0000-0002-8650-4925

Анотація

The ability of novel anticancer drug candidates, europium coordination complexes (EC), to penetrate the phospholipid monolayer composed of dimyristoylphosphatidylcholine (DMPC) was studied using Langmuir monolayer technique. EC were found to insert readily into the lipid monolayer with penetration extent being dependent on both drug structure and initial surface pressure of the lipid film. Evaluation of the limiting surface pressure revealed that all drugs are capable of inserting into the cellular membranes.

Завантаження

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Біографії авторів

Valeriya Trusova, Department of Biological and Medical Physics, V.N. Karazin Kharkov National University4 Svobody Sq., Kharkov, 61022, Ukraine
Galyna Gorbenko, Department of Biological and Medical Physics, V.N. Karazin Kharkov National University 4 Svobody Sq., Kharkov, 61022, Ukraine

Посилання

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Опубліковано
2015-03-25
Цитовано
Як цитувати
Trusova, V., Yudintsev, A., Kutsenko, O., Pakhomova, O., Volinsky, R., Gorbenko, G., Deligeorgiev, T., & Kinnunen, P. (2015). INTERACTION OF EUROPIUM CHELATES WITH LIPID MONOLAYERS. Східно-європейський фізичний журнал, 1(4), 100-105. https://doi.org/10.26565/2312-4334-2014-4-13