Concept of Neutron Source Creation for Nuclear Medicine on the Basis of Linear Electron Accelerator

  • Valentin Kasilov National Science Center “Kharkov Institute of Physics and Technology”, Kharkiv, Ukraine https://orcid.org/0000-0002-1355-311X
  • Sergey Gokov National Science Center “Kharkov Institute of Physics and Technology”, Kharkiv, Ukraine https://orcid.org/0000-0002-3656-3804
  • Sergiy Kalenik National Science Center “Kharkov Institute of Physics and Technology”, Kharkiv, Ukraine https://orcid.org/0000-0002-1460-5081
  • Sergey Kochetov National Science Center “Kharkov Institute of Physics and Technology”, Kharkiv, Ukraine
  • Leonid Saliy National Science Center “Kharkov Institute of Physics and Technology”, Kharkiv, Ukraine
  • Vitaliy Tsyats'ko National Science Center “Kharkov Institute of Physics and Technology”, Kharkiv, Ukraine https://orcid.org/0000-0002-7347-0500
  • Evgen Tsyats'ko National Science Center “Kharkov Institute of Physics and Technology”, Kharkiv, Ukraine
  • Oleg Shopen National Science Center “Kharkov Institute of Physics and Technology”, Kharkiv, Ukraine https://orcid.org/0000-0003-3158-8081
DOI: https://doi.org/10.26565/2312-4334-2021-4-21
Keywords: nuclear medicine, delayed neutrons, thermal neutrons, linear accelerator, neutron source

Abstract

We review the current status of the development of sources of epithermal neutrons sources based on reactors and accelerators for boron neutron capture therapy (BNCT), a promising method of malignant tumor treatment. The scheme is proposed of the source prototype for the production of thermal and epithermal neutrons using the delayed neutrons generated with help of linear electron accelerator at the target containing the fissile material. The results of an experiment are presented in which the half-life curves of radioactive nuclei formed during fission and emitting delayed neutrons are measured. It is shown that an activated target containing fissile material is a compact small-sized source of delayed neutrons. It can be delivered to the shaper, where, using a moderator, an absorber, and a collimator, neutrons of thermal or epithermal energies are formed over a certain period of time, after which this target is sent to the activator, and another target comes in its place. Thus, a pulsed neutron flux is formed. Such a neutron beam can be used in nuclear medicine, in particular, in neutron capture therapy in the treatment of cancer. An important task in the implementation of neutron capture therapy, when irradiating patients, is to control both the intensity and the energy spectrum of the neutron flux. To solve this problem, an earlier developed activation-type neutron ball spectrometer can be used, which will allow optimization of various parameters of the shaper, collimator and filters in order to obtain the most powerful neutron fluxes.

Downloads

Download data is not yet available.

References

H. Hatanaka, Y. Nakagava, Intern. J. Rad. Oncol. Biol. Phys. 28, 1061 (1994), https://doi.org/10.1016/0360-3016(94)90479-0

L.W. Wang, Y.H. Liu, F.I. Chou, S.H. Jiang, Cancer Commun (Lond), 38(1), 37 (2018), https://doi.org/10.1186/s40880-018-0295-y

H. Shiba, K. Takeuchi, R. Hiramatsu, M. Furuse, N. Nonoguchi, S. Kawabata, et al. Neurol Med Chir (Tokyo), 58(12), 487 (2018), https://doi.org/10.2176/nmc.oa.2018-0111

V.A. Trivillin, E.C.C. Pozzi, L.L. Colombo, S.I. Thorp, M.A. Garabalino, M.A. Hughes, et al. Radiat. Environ. Biophys. 56(4), 365 (2017), https://doi.org/10.1007/s00411-017-0704-7

J. Miyabe, R. Ohgaki, K. Saito, L. Wei, L. Quan, C. Jin, et al. J Pharmacol. Sci. 139, 215 (2019), https://doi.org/10.1016/j.jphs.2019.01.01

S.Y. Taskaev, Phys Part Nucl. 46, 956 (2015), https://doi.org/10.1134/S1063779615060064

S.Y. Taskaev, Boron Neutron Capture Therapy. Physics of Atomic Nuclei, 84(2), 207 (2021), https://doi.org/10.1134/S106377882101021X

M. Suzuki, Int. J. Clin. Oncol. 25, 43 (2019), https://doi.org/10.1007/s10147-019-01480-4

V.I. Kasilov, S.P. Gokov, A.N. Dovbnya, S.A. Kalenik, K.S. Kokhnyuk, S.S. Kochetov, A.A. Khomich, and O.A. Shopen, East Eur. J. Phys. 3(3), 64 (2016), https://doi.org/10.26565/2312-4334-2016-3-05

V.M. Pixaykin, L.E. Kazakov, G.G. Korolev, S.G. Isaev, V.A. Roschenko, and M.Z. Tarasko, Atomic energy, 92(2), 135 (2002), http://elib.biblioatom.ru/text/atomnaya-energiya_t92-2_2002/go,0/. (in Russian)

A.Yu. Buki, S.A. Kalenik, I.L. Semisalov, I.S. Timchenko, A.S. Zadvorny, M.G. Shevchenko, V.J. Kasilov, S.P. Gokov, S.S. Kochetov, G.I. Ledovskoy, and P.L. Makhnenko, The Journal of Kharkiv National University, physical series «Nuclei, Particles, Fields», 1025(4), 35 (2012), http://nuclear.univer.kharkov.ua/lib/1025_4(56)_12_p35-42.pdf. (in Russian)

Published
2021-12-10
Cited
How to Cite
Kasilov, V., Gokov, S., Kalenik, S., Kochetov, S., Saliy, L., Tsyats’ko, V., Tsyats’ko, E., & Shopen, O. (2021). Concept of Neutron Source Creation for Nuclear Medicine on the Basis of Linear Electron Accelerator. East European Journal of Physics, (4), 160-163. https://doi.org/10.26565/2312-4334-2021-4-21
Issue
No. 4 (2021): East European Journal of Physics
Section
Original Papers

Copyright (c) 2021 Valentin I. Kasilov, Sergey P. Gokov, Sergiy A. Kalenik, Sergey S. Kochetov, Leonid D. Saliy, Vitaliy V. Tsyats'ko, Evgen V. Tsyats'ko, Oleg A. Shopen

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

    • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
    • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
    • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).