Nanocomposite materials based on hydroxyapatite and sodium alginate: synthesis and characteristics
Keywords:
nanocomposites, hydroxyapatite, sodium alginate, x-ray diffraction, infrared spectroscopy, transmission microscopy
Abstract
This work is devoted to the development and optimization of the synthesis methodof nanostructured biopolymer-apatite composite materials for medical applications with different ratios of polymer (sodium alginate, SA) and inorganic (hydroxyapatite, HA) phases and research their properties. Composition, structure and morphology of the samples by FTIR spectroscopy, X-ray diffraction and transmission electron microscopy (TEM) were characterized. Porosity, degree of swelling and in vitro response on bioactivity in physiological solution obtained compositesweredetermined. The formation in the presence of sodium alginate hydroxyapatite phase with needle structure and average crystallite size 23 nm with simultaneous formation biopolymer matrix due to the interaction of positively charged calcium ions (Ca2+) and negatively charged carboxyl groups (COO-) by instrumental methodswasconfirmed. The pH changing of physiological solution in the presence of samples testifies their bioactivitDownloads
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References
1. Materials in particulate form for tissue engineering. Applications in bone / G.A.Silva, O.P.Coutinho, P.Ducheyene, R.L.Reis // J. Tissue Eng. Regen. Med. – 2007. – V. 1., № 2. – P. 97–109.
2. Bioresorbable composite bone paste using polysaccharide based nano hydroxyapatite / R. Murugan, S. Ramakrishna // Biomaterials. – 2004. – V. 25. – P. 3829–3835.
3. Sacrificial bonds heal bone. Nature / J. Currey // Biomaterials. – 2001. – V. 414. – P. 699–708.
4. Reassessment of long-term use of dense HA as dental implant: case report / M. Ogiso // Journal of Biomedical Materials Research. – 1998. – V. 43, № 3. – P. 318–320.
5. Biomimetically synthesized polymer-hydroxyapatite sheet like nano-composite / S. Nayar, A.K. Pramanick, B.K. Sharma, G. Das, B. Ravi Kumar, A. Sinha // Journal of Materials Science: Materials in Medicine. – 2008. – V. 19., № 1. – P. 301–304.
6. Relationships between polyphosphate chemistry, biochemistry and apatite biomineralization / S.J. Omelon, M.D.Grynpas // Chem. Rev. – 2008. – V. 108. – P. 4694–4715.
7. Hydroxyapatite/ bioactive glass films produced by a sol–gel method: in vitro behavior / N.C. Koseoglu, A. Buyukaksoy, A.Y. Oral, M.H. Aslan // Adv. Eng. Mater. – 2009. – V. 11., № 11. – P. B194– B199.
8. Nanomedicine for implants: A review of studies and necessary experimental tools / H.Liu, T.J.Webster // Biomaterials. – 2007. – V. 28., № 2. – P. 354 – 369.
9. Development of nano-sized hydroxyapatite reinforced composites for tissue engineering scaffolds / J. Huang, Y. Wan Lin, X. Wei Fu, S.M. Best [et al.] // Journal of Materials Science: Materials in Medicine. – 2007. – V. 18. – P. 2151–2157.
10. Performance of adhesive bone cement containing hydroxyapatite particles / S. Morita, K. Furuya, K. Ishihara, N. Nakabayashi // Biomaterials. – 1998. – V. 19. – P. 1601–1606.
11. Synthesis and characterization of grafted nanohydroxyapatites using functionalized surface agents / S. Haque, I. Rehman, J.A. Darr // Langmuir. – 2007. – V. 23. – P. 6671–6676.
12. Hydroxyapatite-alginate biocomposite promotes bone mineralization in different length scales in vivo / F.L. De Paula, I.C. Barreto, M.H. Rocha-Leao [et al.] // Frontiers of Materials Science in China. – 2009. – V. 3. – P. 145–153.
13. Synthesis and biocompatibility of porous nano-hydroxyapatite / collagen / alginate composite / S.M. Zhang, F.Z. Cui, S.S. Liao, Y. Zhu, L. Han // Journal of Materials Science: Materials in Medicine. – 2003. – V. 14. – P. 641–645.
14. Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W / T. Kokubo, H. Kushitani, S.Sakka, T.Kitsugi, T.Yamamuro // Journal of Biomedical Materials Research. – 1990. – V. 24. – P. 721-734.
15. Chemical synthesis and characterization of hydroxyapatite (HAp)-poly (ethylene co vinyl alcohol) (EVA) nanocomposite using a phosphonic acid coupling agent for orthopedic applications / N. Pramanik, S. Mohapatra, P. Bhargava [et al.] // Mater . Sci. Eng. С. – 2009. – V. 29. – Р. 228–236.
16. Development of nanocomposites based on hydroxyapatite/sodium alginate: synthesis and characterization / M. Rajkumar, N. Meenakshisundaram, V. Rajendran // Materials Characterization. – 2011. – V. 62, № 5. – P. 469–479.
17. Структурні та субструктурні особливості апатит-біополімерних композитів: порівняння даних рентгенівської дифракції та просвічуючої електронної мікроскопії з електронною дифракцією / В.М.Кузнецов, Л.Б.Суходуб, Л.Ф.Суходуб // Журнал нано- та електронної фізики. – 2014. – Т.6., № 4. – С.04039-1-04039-6. / Strukturnі ta substrukturnі osoblivostі apatit-bіopolіmernih kompozitіv: porіvnjannja danih rentgenіvs'koї difrakcії ta prosvіchujuchoї elektronnoї mіkroskopії z elektronnoju difrakcієju / V.M.Kuznecov, L.B.Suhodub, L.F.Suhodub // Zhurnal nano- ta elektronnoї fіziki. – 2014. – T.6., № 4. – S.04039-1-04039-6.
18. Mineralization of Chitosan scaffolds with nano-apatite by double diffusion technigue / I.Manjubala, S.Sheler, Jorg Bossert, Klaus D.Jandt // Acta biomaterialia. – 2006. – V. 2., № 1. – P. 75-84.
19. A novel ordered nano hydroxyapatite coating electrochemically deposited on titanium substrate / R. Hu, C.J. Lin, H.Y. Shi // J.Biomed. Mater. Res. A. – 2007. – V. 80. – P. 687–692.
20. An alternative chemical route for the synthesis and thermal stability of chemically enriched hydroxyapatite / D. Choi, P.N. Kumta // J. Am. Ceram. Soc. – 2006. – V. 89. – P. 444–449.
21. In situ processing and properties of nanostructured hydroxyapatite/alginate composite / L. Wang, Y. Li, C. Li // J. Nanopart. Res. – 2009. – V. 11. – P. 691–699.
22. The crystallization of hydroxyapatite in the presence of sodium alginate / P. Malkaj, E. Pierri, E. Dalas // Journal of Materials Science: Materials in Medicine. – 2005. – V. 16. – P. 733–737.
23. Synthesis and characterization of hydroxyapatite/b-tricalcium phoshate nanocomposites using microwawe irradiation / A. Farzadi, M. Solati-Hashjin, F. Bakhshi, A.Aminian // Ceramics International. – 2011. – V.37. – P. 65 – 71.
2. Bioresorbable composite bone paste using polysaccharide based nano hydroxyapatite / R. Murugan, S. Ramakrishna // Biomaterials. – 2004. – V. 25. – P. 3829–3835.
3. Sacrificial bonds heal bone. Nature / J. Currey // Biomaterials. – 2001. – V. 414. – P. 699–708.
4. Reassessment of long-term use of dense HA as dental implant: case report / M. Ogiso // Journal of Biomedical Materials Research. – 1998. – V. 43, № 3. – P. 318–320.
5. Biomimetically synthesized polymer-hydroxyapatite sheet like nano-composite / S. Nayar, A.K. Pramanick, B.K. Sharma, G. Das, B. Ravi Kumar, A. Sinha // Journal of Materials Science: Materials in Medicine. – 2008. – V. 19., № 1. – P. 301–304.
6. Relationships between polyphosphate chemistry, biochemistry and apatite biomineralization / S.J. Omelon, M.D.Grynpas // Chem. Rev. – 2008. – V. 108. – P. 4694–4715.
7. Hydroxyapatite/ bioactive glass films produced by a sol–gel method: in vitro behavior / N.C. Koseoglu, A. Buyukaksoy, A.Y. Oral, M.H. Aslan // Adv. Eng. Mater. – 2009. – V. 11., № 11. – P. B194– B199.
8. Nanomedicine for implants: A review of studies and necessary experimental tools / H.Liu, T.J.Webster // Biomaterials. – 2007. – V. 28., № 2. – P. 354 – 369.
9. Development of nano-sized hydroxyapatite reinforced composites for tissue engineering scaffolds / J. Huang, Y. Wan Lin, X. Wei Fu, S.M. Best [et al.] // Journal of Materials Science: Materials in Medicine. – 2007. – V. 18. – P. 2151–2157.
10. Performance of adhesive bone cement containing hydroxyapatite particles / S. Morita, K. Furuya, K. Ishihara, N. Nakabayashi // Biomaterials. – 1998. – V. 19. – P. 1601–1606.
11. Synthesis and characterization of grafted nanohydroxyapatites using functionalized surface agents / S. Haque, I. Rehman, J.A. Darr // Langmuir. – 2007. – V. 23. – P. 6671–6676.
12. Hydroxyapatite-alginate biocomposite promotes bone mineralization in different length scales in vivo / F.L. De Paula, I.C. Barreto, M.H. Rocha-Leao [et al.] // Frontiers of Materials Science in China. – 2009. – V. 3. – P. 145–153.
13. Synthesis and biocompatibility of porous nano-hydroxyapatite / collagen / alginate composite / S.M. Zhang, F.Z. Cui, S.S. Liao, Y. Zhu, L. Han // Journal of Materials Science: Materials in Medicine. – 2003. – V. 14. – P. 641–645.
14. Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W / T. Kokubo, H. Kushitani, S.Sakka, T.Kitsugi, T.Yamamuro // Journal of Biomedical Materials Research. – 1990. – V. 24. – P. 721-734.
15. Chemical synthesis and characterization of hydroxyapatite (HAp)-poly (ethylene co vinyl alcohol) (EVA) nanocomposite using a phosphonic acid coupling agent for orthopedic applications / N. Pramanik, S. Mohapatra, P. Bhargava [et al.] // Mater . Sci. Eng. С. – 2009. – V. 29. – Р. 228–236.
16. Development of nanocomposites based on hydroxyapatite/sodium alginate: synthesis and characterization / M. Rajkumar, N. Meenakshisundaram, V. Rajendran // Materials Characterization. – 2011. – V. 62, № 5. – P. 469–479.
17. Структурні та субструктурні особливості апатит-біополімерних композитів: порівняння даних рентгенівської дифракції та просвічуючої електронної мікроскопії з електронною дифракцією / В.М.Кузнецов, Л.Б.Суходуб, Л.Ф.Суходуб // Журнал нано- та електронної фізики. – 2014. – Т.6., № 4. – С.04039-1-04039-6. / Strukturnі ta substrukturnі osoblivostі apatit-bіopolіmernih kompozitіv: porіvnjannja danih rentgenіvs'koї difrakcії ta prosvіchujuchoї elektronnoї mіkroskopії z elektronnoju difrakcієju / V.M.Kuznecov, L.B.Suhodub, L.F.Suhodub // Zhurnal nano- ta elektronnoї fіziki. – 2014. – T.6., № 4. – S.04039-1-04039-6.
18. Mineralization of Chitosan scaffolds with nano-apatite by double diffusion technigue / I.Manjubala, S.Sheler, Jorg Bossert, Klaus D.Jandt // Acta biomaterialia. – 2006. – V. 2., № 1. – P. 75-84.
19. A novel ordered nano hydroxyapatite coating electrochemically deposited on titanium substrate / R. Hu, C.J. Lin, H.Y. Shi // J.Biomed. Mater. Res. A. – 2007. – V. 80. – P. 687–692.
20. An alternative chemical route for the synthesis and thermal stability of chemically enriched hydroxyapatite / D. Choi, P.N. Kumta // J. Am. Ceram. Soc. – 2006. – V. 89. – P. 444–449.
21. In situ processing and properties of nanostructured hydroxyapatite/alginate composite / L. Wang, Y. Li, C. Li // J. Nanopart. Res. – 2009. – V. 11. – P. 691–699.
22. The crystallization of hydroxyapatite in the presence of sodium alginate / P. Malkaj, E. Pierri, E. Dalas // Journal of Materials Science: Materials in Medicine. – 2005. – V. 16. – P. 733–737.
23. Synthesis and characterization of hydroxyapatite/b-tricalcium phoshate nanocomposites using microwawe irradiation / A. Farzadi, M. Solati-Hashjin, F. Bakhshi, A.Aminian // Ceramics International. – 2011. – V.37. – P. 65 – 71.
Cited
How to Cite
Мартинюк, О. О., Суходуб, Л. Б., & Суходуб, Л. Ф. (1). Nanocomposite materials based on hydroxyapatite and sodium alginate: synthesis and characteristics. Biophysical Bulletin, 1(33), 48-59. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/4334
Section
Medical physics
Copyright (c) 2015 Мартинюк О. О., Суходуб Л. Б., Суходуб Л. Ф.
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