Identification of calcium-phosphate biomaterials based on characteristic ions in mass spectra
Keywords:
hydroxyapatite, plasma desorption mass spectrometry, ion formation, characteristic ions
Abstract
Hydroxyapatite is one of the best materials for the production or modification of orthopaedic implants; it
is also can be a part of synthetic composite materials for bone regeneration. Its biological activity is
caused by structural similarity to the inorganic part of bone (called often the non-stoichiometric
hydroxyapatite or bioapatite). Hydroxyapatite can be resorbed by the surrounding bone tissue and
replaced by a natural bone, which results in good bonding between the implant and tissue. There are a lot
of technologies to develop hydroxyapatite biomaterials. The advantages and limitations of each technique
should be studied individually; in every specific case one should take into account the properties of
resulting hydroxyapatite, its chemical purity, micro- and nanostructure, macroscopic structural features,
bone connectivity strength, biocompatibility. We have applied desorption mass spectrometry with the
ionization of sample by 252Cf fission fragments (PD MS) for the analysis of synthetic hydroxyapatite. The
ion species desorbed from the hydroxyapatite surface under fission fragment impacts were studied, and
three series of polyatomic ions have been detected, two of which had not been described in earlier in
literature.
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References
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2. Dorozhkin S.V. Calcium Orthophosphates in Nature, Biology and Medicine / S.V. Dorozhkin // Materials. – 2009. – V. 2. – P. 399–498.
3. Dorozhkin S.V. Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine / S.V. Dorozhkin // Materials. – 2009. – V. 2. – P. 1975–2045.
4. Dorozhkin S.V. Calcium orthophosphates / S.V. Dorozhkin // J. Mater. Sci.– 2007.– V.42.– P. 1061–1095.
5. Dorozhkin S.V. Biocomposites and hybrid biomaterials based on calcium orthophosphates / S.V. Dorozhkin // Biomatter. – 2011. ¬– V. 1:1. – P. 3–56.
6. Kanazava T. Neorganicheskie fosfatnye materialy / T. Kanazava [per. s angl. pod red. akad. A.P. Shpaka i V.L. Karbovskogo]. – K.: Naukova dumka, 1998. – 297 s.
7. Cazalbou S. Adaptative physico-chemistry of bio-related calcium phosphates / S. Cazalbou, C. Combes, D. Eichert, C. Rey // J. Mater. Chem. – 2004. – V. 14. – P. 2148–2153.
8. Chakraborty S. Structural and microstructural characterization of bioapatites and synthetic hydroxyapatite using X–ray powder diffraction and Fourier transform infrared techniques / S. Chakraborty, S. Bag, S. Pal // J. Appl. Cryst. – 2006. – V. 39. – P. 385–390.
9. Diagnostika apatitopodobnyh struktur na osnove welochnozemel'nyh metallov / A.P.Shpak, V.L. Karbovskij, V.V. Trachevskij [i dr.] // Metallofiz. novejshie tehnol.– 2003.– T.25.– №10.– C. 1279–1301.
10. Elliott J.C. Structure and Chemistry of the Apatites and Other Calcium Orthophosphates / J.C. Elliott Amsterdam: Elsevier, 1994. – 389 p. – (Studies in Inorganic Chemistry; No. 18).
11. Suchanek W. Processing and properties of hydroxyapatite–based biomaterials for use as hard tissue replacement implants / W. Suchanek, M. Yoshimura // J. Mater. Res. – 1998.– V. 13., № 1.– P. 94–117.
12. Preparation and properties of inhomogeneous hydroxyapatite ceramics / Z. Zyman, I. Ivanov, V. Glushko [et al.] // J. Biomed. Mater. Res. – 1999. – V. 46. – P. 135–140.
13. Gross K.A. Biomedical Application of Apatites / K.A. Gross, C.C. Berndt // Phosphates: geochemical, geobiological and materials importance. Series: Reviews in mineralogy and geochemistry, Vol. 48. [editors Kohn M.J., Rakovan J., Hughes J.M.] – Mineralogical Society of America, Washington, DC. – 2002. – P. 631–672.
14. White T.J. Structural derivation and crystal chemistry of apatites / T.J. White, D. ZhiLi // Acta Crystallographica. – 2003. – V.59.– P. 1–16.
15. Vallet-Regí M. Ceramics for medical applications / M. Vallet-Regí // J. Chem. Soc., Dalton Trans. – 2001. – P. 97–108.
16. The effect of organic ligands on the crystallinity of calcium phosphate / J.A.M. van der Houwen, G. Cressey, B.A. Cressey, E. Valsami-Jones // J. Crystal Growth. – 2003. – V. 249. – P. 572–583.
17. Crystal Structure of Calcium-Deficient Carbonated Hydroxyapatite. Thermal Decomposition. / T.I. Ivanova, O.V. Frank-Kamenetskaya, A.B. Kol'tsov, V.L. Ugolkov // J. Solid State Chem. – 2001. – V. 160. – P. 340–349.
18. Leventouri Th. Synthetic and biological hydroxyapatites: Crystal structure questions / Th. Leventouri // Biomaterials. – 2006. – V. 27. – P. 3339–3342.
19. Wopenka B. A mineralogical perspective on the apatite in bone / B. Wopenka, J.D. Pasteris // Material Sci. Eng. – 2005. – V. C25. – P. 131–143.
20. Calcium phosphate phase identification using XPS and time–of–flight cluster SIMS / C.C. Chusuei, D.W. Goodman, M.J. Van Stipdonk, [et al.] // Anal. Chem. – 1999. – V. 71. – P. 149–153.
21. Application of 252Cf plasma desorption mass spectrometry in dental research / H.-W. Fritsch, L. Schmidt, P. Köhl, [et al.] // Int. J. Mass Spectrom. Ion Proc. – 1993. – V. 126. – P. 191–196.
22. Identification of human calculi with time-of-flight secondary ion mass spectrometry / C.A.A. Ghumman, O.M.T. Carreira, A.M.C. Moutinho, [et al.] // Rapid Commun. Mass Spectrom. – 2010. – V. 24. – P. 185–190.
23. Wang C. Ab initio interionic potentials for CaO by multiple lattice inversion / C. Wang, S. Zhang, N.-X. Chen // J. Alloys Compounds. – 2005. – V. 388. – P. 195–207.
24. Liu H. Characterization of phosphate–containing metabolites by calcium adduction and electron capture dissociation / H. Liu, H. Ju Yoo, K. Håkansson // J. Am. Soc. Mass Spectrom. – 2008. – V. 19. – P. 799–808.
25. Carl D.R. Binding energies for the inner hydration shells of Ca2+: An experimental and theoretical investigation of Ca2+(H2O)x complexes (x = 5–9) / D.R. Carl, R.M. Moision, P.B. Armentrout // Int. J. Mass Spectrom. – 2007. – V. 265. – P. 308–325.
26. Ab initio modelling of calcium phosphate clusters and their vibrational spectra / I.E. Boldeskul, L.F. Sukhodub, A.N. Kalinkevich, V.D. Khavryutchenko // Cond. Matter Physics. – 2006. – V. 9, No. 4(48). – P. 669–679.
27. Theoretical study of adsorption of tabun on calcium oxide clusters / A. Michalkova, Y. Paukku, D. Majumdar, J. Leszczynski // Chem. Phys. Lett. – 2007. – V. 438. – P. 72–77.
28. Calcium phosphate clusters / N. Kanzaki, G. Treboux, K. Onuma, [et al.] // Biomaterials. – 2001. – V. 22. – P. 2921–2929.
29. TOF-SIMS analysis of the interface between bone and titanium implants – Effect of porosity and magnesium coating / H. Nygren, C. Eriksson, K. Hederstierna, P. Malmberg // Appl. Surf. Sci. – 2008. – V. 255. – P. 1092–1095.
30. ToF-SIMS images and spectra of biomimetic calcium silicate–based cements after storage in solutions simulating the effects of human biological fluids / A. Torrisi, V. Torrisi, N. Tuccitto, [et al.] // Int. J. Mass Spectrom. – 2010. – V. 289. – P. 150–161.
31. Electrospray ionization tandem mass spectrometric study of salt cluster ions. Part 1 - Investigations of alkali metal chloride and sodium salt cluster ions / C. Hao, R.E. March, T.R. Croley, [et al.] // J. Mass Spectrom. – 2001. – V. 36. – P. 79–96.
32. Hao C. Electrospray ionization tandem mass spectrometric study of salt cluster ions: Part 2 - Salts of polyatomic acid groups and of multivalent metals / C. Hao, R.E. March // J. Mass Spectrom. – 2001. – V. 36. – P. 509–521.
Cited
How to Cite
Kalinkevich, A. N., Danilchenko, S. N., & Sukhodub, L. F. (1). Identification of calcium-phosphate biomaterials based on characteristic ions in mass spectra. Biophysical Bulletin, 2(27). Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/2546
Section
Methods of biophysical investigations
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