Kinetic model of changes in genetic control of cells in state of proliferation and differentiation
Keywords:
proliferation, differentiation, reaction rate constant, kinetic model, genetic control
Abstract
In this work it is built kinetic model of changes in genetic control of cells in state of proliferation and
differentiation. It is shown that proliferation and differentiation in cells are controlled on gene,chromosomal, membrane and cellular levels. Onset of proliferation is determined by histone genes,transport genes and genes-stimulators of proliferation. Activation of these genes is mediated bytranscriptional factors which are produced by cell after activation of cell cycle genes, which isconditioned by the level of depolarization of cell membrane. Onset of differentiation is determined byactivation of structural genes and synthesis of structural cell proteins. Activation of these genes is conditioned by hyperpolarization of cell membrane. Our kinetic model assumes and integrates changes onall levels in cells in state of proliferation and differentiation.
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References
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3. Zavitz K. Controlling cell proliferation in differentiating tissues: genetic analysis of negative regulators of Gl-S-phase progression / K. Zavitz, L. Zipursky // Current opinion in cell biology. – 1997. – V. 9. – P. 773–781.
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6. Allen R. E. Hepatocyte growth factor activates quiescent skeletal muscle satellite cells in vitro / R. E. Allen, S. M. Sheehan, R. G. Taylor // Journal of Cellular Physiology. – 1995. – V. 165(2). – P. 307–312.
7. Floss T. A role for FGF-6 in skeletal muscle regeneration / T. Floss, H. H. Arnold, T. Braun // Genes Dev. – 1997. – V. 11(16). – P. 2040–2051.
8. Kastner S.Gene Expression Patterns of the Fibroblast Growth Factors and Their Receptors During Myogenesis of Rat Satellite Cells / S. Kastner, M. C. Elias, A. J. Rivera // Journal of Histochemistry and Cytochemistry. – 2000. – V. 48(8). – P. 1079–1096.
9. Lee M. H. Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor β1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation / M. H. Lee, A. Javed, H. J. Kim // J Cell Biochem. – 1999. – V. 73. – P. 114–125.
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11. Seale P. Pax7 is required for the specification of myogenic satellite cells / P. Seale, L. A. Sabourin, A. Girgis-Gabardo // Cell. – 2000. – V. 102(6). – P. 777–786.
12. Sheehan S. M. Skeletal muscle satellite cell proliferation in response to members of the fibroblast growth factor family and hepatocyte growth factor / S. M. Sheehan, R. E. Allen // J Cell Physiol. – 1999. – V. 181(3). – P. 499–506.
13. Tatsumi R. HGF/SF Is Present in Normal Adult Skeletal Muscle and Is Capable of Activating Satellite Cells / R. Tatsumi, J. E. Anderson, C. J. Nevoret // Developmental Biology. – 1998. – V. 194(1). – P. 114–128.
14. Tatsumi R. Release of Hepatocyte Growth Factor from Mechanically Stretched Skeletal Muscle Satellite Cells and Role of pH and Nitric Oxide / R. Tatsumi, A. Hattori, Y. Ikeuchi // Molecular Biology of the Cell. – 2002. – V. 13(8). – P. 2909–2918.
15. Yablonka-Reuveni Z. Fibroblast Growth Factor Promotes Recruitment of Skeletal Muscle Satellite Cells in Young and Old Rats / Z. Yablonka-Reuveni, R. Seger, A. J. Rivera // Journal of Histochemistry and Cytochemistry. – 1999. – V. 47(1). – P. 23–42.
16. Canalis E. Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton / E. Canalis, A. N. Economides, E. Gazzero // Endocr. Rev. – 2003. – V. 24(2). – P. 218–235.
17. Füchtbauer E. M. MyoD and myogenin are coexpressed in regenerating skeletal muscle of the mouse / E. M. Füchtbauer, H. Westphal // Developmental Dynamics: An Official Publication of the American Association of Anatomists. – 1992. – V. 193(1). – P. 34–39.
18. Grounds M. D. Identification of skeletal muscle precursor cells in vivo by use of MyoD1 and myogenin probes / M. D. Grounds, K. L. Garrett, M.C. Lai // Cell and Tissue Research. – 1992. – V. 267(1). – P. 99–104.
19. Yablonka-Reuveni Z. Temporal expression of regulatory and structural muscle proteins during myogenesis of satellite cells on isolated adult rat fibers / Z. Yablonka-Reuveni, A. J. Rivera // Developmental Biology. – 1994. – V. 164(2). – P. 588–603.
20. Zammit P. S. Muscle satellite cells adopt divergent fates: a mechanism for self-renewal / P. S. Zammit, J. P. Golding, Y. Nagata // The Journal of Cell Biology. – 2004. – V. 166(3). – P. 347–357.
21. Sundelacruz S. Role of Membrane Potential in Regulation of Cell Proliferation and Differentiation / S. Sundelacruz, M. Levin, D. Kaplan // Stem Cell Rev and Rep. – 2009. – V. 5. – P. 231–246.
22. Sundelacruz S. Membrane Potential Controls Adipogenic and Osteogenic Differentiation of Mesenchymal Stem Cells / S. Sundelacruz, M. Levin, D. Kaplan // PLoS ONE. – 2008. – V. 3(11). – P. 325–342.
23. Kai X. Identification of proliferation/differentiation switch in the cellular network of multicellular organisms / X. Kai, D. Dong, Z. Shanshan // Plos Computational Biology. – 2006. – V. 4. – P. 124–148.
24. Cone C. D. Unified theory on the basic mechanism of normal mitotic control and oncogenesis / C. D. Cone // Journal of Theoretical Biology. – 1971. – V. 30. – P. 151–181.
25. Binggeli R. Membrane potentials and sodium channels: Hypotheses for growth regulation and cancer formation based on changes in sodium channels and gap junctions / R. Binggeli, R. C. Weinstein // Journal of Theoretical Biology. – 1986. – V. 123. – P. 377–401.
26. Putney L. K. Na-H Exchange-dependent Increase in Intracellular pH Times G2/M Entry and Transition / L. K. Putney // Journal of Biological Chemistry. – 2003. – V. 278. – P. 44645–44649.
Cited
How to Cite
Stadnyk, I. V., & Sanagursky, D. I. (1). Kinetic model of changes in genetic control of cells in state of proliferation and differentiation. Biophysical Bulletin, 1(29). Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/2349
Section
Biophysics of complex systems
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