Application of the theory of interceptor-protector action to in vitro biological experiment
Keywords:
hetero-association, DNA, interceptor action, mutagen, protector action
Abstract
The purpose of this paper is to ascertain whether the theory of interceptor-protector action (IPA) can be applied
to quantitation of the so far published data of biological experiments in vitro regarding the cases when differentDNA-binding ligands are administered simultaneously. The basic assumptions of the IPA theory were clearly formulated. Two different ways for estimation of biological effect were considered (viz. point estimation and estimation using concentration dependence of the AD factor). It was found that the IPA theory agrees with data from mutagenic test and the data from the experiment in proliferating cell lines
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References
1. Evstigneev M. P. DNA-binding aromatic drug molecules: Physico-chemical interactions and their biological roles / M. P. Evstigneev. — Saarbrücken: Lambert Academic Publishing. – 2010. – 96 p.
2. Traganos F. Caffeine modulates the effects of DNA-intercalating drugs in vitro: A flow cytometric and spectrophotometric analysis of caffeine interaction with novantrone, doxorubicin, ellipticine, and the doxorubicin analogue AD198 / F. Traganos, J. Kapuściński, Z. Darzynkiewicz // Cancer Res. – 1991. – V. 51, № 14. – P. 3682–3689.
3. Piosik J. The modulation by xanthines of the DNA-damaging effect of polycyclic aromatic agents: Part II. The stacking complexes of caffeine with doxorubicin and mitoxantrone / J. Piosik, M. Zdunek, J. Kapuściński // Biochem. Pharmacol. – 2002. – V. 63, № 4. – P. 635–646.
4. Traganos F. Caffeine reverses the cytotoxic and cell kinetic effects of novantrone (mitoxantrone) / F. Traganos, B. Kaminska-Eddy, Z. Darzynkiewicz // Cell Prolif. – 1991. – V. 24, № 3. – P. 305–319.
5. Veselkov D.A. Molecular basis of the protective action of caffeine on the complexation of intercalating ligands with DNA / D.A. Veselkov, D.B. Davies, L.N. Djimant, A.N. Veselkov // Biopolym. Cell. – 2000. – V. 16, № 6. – P. 468–481.
6. Hetero-association of caffeine and aromatic drugs and their competitive binding with a DNA oligomer / D. B. Davies, D. A. Veselkov, L. N. Djimant, A. N. Veselkov // Eur. Biophys. J. – 2001. – V. 30, № 5. – P. 354–366.
7. 1H NMR analysis of the interaction of antibiotic mitoxantrone with DNA in the presence of caffeine in aqueous solution / A. N. Veselkov, S. A. Vysotsky, M. P. Evstigneev [et al.] // Biopolym. Cell. – 2002. – V. 18, № 4. – P. 287–296.
8. Davies D. B. NMR determination of the hetero-association of phenanthridines with daunomycin and their competitive binding to a DNA oligomer / D. B. Davies, D. A. Veselkov, A. N. Veselkov // Eur. Biophys. J. – 2002. – V. 31, № 2. – P. 153–162.
9. Pietrzak M. The “interceptor” properties of chlorophyllin measured within the three-component system: Intercalator-DNA-chlorophyllin / M. Pietrzak, Z. Wieczorek, J. Wieczorek, Z. Darzynkiewicz // Biophys. Chem. – 2006. – V. 123, № 1. – P. 11–19.
10. Attenuation of acridine mutagen ICR-191 — DNA interactions and DNA damage by the mutagen interceptor chlorophyllin / M. Pietrzak, H.D. Halicka, Z. Wieczorek [et al.] // Biophys. Chem. – 2008. – V. 135, № 1-3. – P. 69–75.
11. De-intercalation of ethidium bromide and propidium iodine from DNA in the presence of caffeine / J. Piosik, K. Wasielewski, A. Woziwodzka [et al.] // Cent. Eur. J. Biol. – 2010. – V. 5, № 1. – P. 59–66.
12. Evstigneev M. P. Complexation of daunomycin with a DNA oligomer in the presence of an aromatic vitamin (B2) determined by NMR spectroscopy / M. P. Evstigneev, Yu. V. Mykhina, D. B. Davies // Biophys. Chem. – 2005. – V. 118, № 2-3. – P. 118–127.
13. Evstigneev M. P. Complexation of norfloxacin with DNA in the presence of caffeine / M. P. Evstigneev, K. A. Rybakova, D. B. Davies // Biophys. Chem. – 2006. – V. 121, № 2. – P. 84–95.
14. Evstigneev M. P. Complexation of anthracycline drugs with DNA in the presence of caffeine / M. P. Evstigneev, V. V. Khomich, D. B. Davies // Eur. Biophys. J. – 2006. – V. 36, № 1. – P. 1–11.
15. Quantitation of the molecular mechanisms of biological synergism in a mixture of DNA-acting aromatic drugs / M. P. Evstigneev, A. O. Lantushenko, V. P. Evstigneev [et al.] // Biophys. Chem. – 2008. – V. 132, № 2-3. – P. 148–158.
16. Complexation of biologically active aromatic compounds with DNA in the presence of theophylline / A. A. Hernandez Santiago, D. D. Andrejuk, A.-M. Cervantes Tavera [et al.] // J. Biol. Phys. – 2009. – V. 35, № 2. – P. 115–126.
17. Quantification of the interceptor action of caffeine on the in vitro biological effect of the anti-tumour agent topotecan / M. P. Evstigneev, A. A. Mosunov, V. P. Evstigneev [et al.] // Eur. Biophys. J. – 2011. – V. 40, № 8. – P. 969–980.
18. General analysis of competitive binding in drug-interceptor-DNA systems / A. S. Buchelnikov, A. A. Hernandez Santiago, M. Gonzalez Flores [et al.] // Eur. Biophys. J. – 2012. – V. 41, № 3. – P. 273–283.
19. Протекторное действие витамина B2 по отношению к антибиотику топотекану in vitro / А. О. Лантушенко, А. А. Мосунов, З. Даржинкевич, М. П. Евстигнеев // Физика живого. – 2007. – Т. 15, № 2. – С. 18–23.
20. Antitumor effect of C60 fullerene in combination with doxorubicin / S. V. Prylutska, Yu. M. Kichmarenko, M. P. Evstigneev [et al.] // Cancer Nano (submitted).
21. Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline / J. Piosik, K. Ulanowska, A. Gwizdek-Wiśniewska [et al.] // Mutat. Res., Fundam. Mol. Mech. Mutagen. – 2003. – V. 530, № 1-2. – P. 47–57.
22. Formation of stacking complexes between caffeine (1,2,3-trimethylxanthine) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine may attenuate biological effects of this neurotoxin / K. Ulanowska, J. Piosik, A. Gwizdek-Wiśniewska, G. Węgrzyn // Bioorg. Chem. – 2005. – V. 33, № 5. – P. 402–413.
23. Methylxanthines (caffeine, pentoxifylline and theophylline) decrease the mutagenic effect of daunomycin, doxorubicin and mitoxantrone / J. Piosik, A. Gwizdek-Wiśniewska, K. Ulanowska [et al.] // Acta Biochim. Pol. – 2005. – V. 52, № 4. – P. 923–926.
24. Woziwodzka A. Caffeine, pentoxifylline and theophylline form stacking complexes with IQ-type heterocyclic aromatic amines / A. Woziwodzka, A. Gwizdek-Wiśniewska, J. Piosik // Bioorg. Chem. – 2011. – V. 39, № 1. – P. 10–17.
25. Dashwood R. Antimutagenic potency of chlorophyllin in the Salmonella assay and its correlation with binding constants of mutagen-inhibitor complexes / R. Dashwood, D. Guo // Environ. Mol. Mutagen. – 1993. – V. 22, № 3. – P. 164–171.
26. Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine / R. J. Turesky, S. C. Rossi, D. H. Welti [et al.] // Chem. Res. Toxicol. – 1992. – V. 5, № 4. – P. 479–490.
27. Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish / T. Sugimura, K. Wakabayashi, H. Nakagama, M. Nagao // Cancer Sci. – 2004. – V. 95, № 4. – P. 290–299.
28. On the reliability of quantitation of biological effect in drug-interceptor-DNA systems / A. S. Buchelnikov, V. P. Evstigneev, L. E. Rodríguez Oropeza, M. P. Evstigneev // Eur. Biophys. J. – 2013. – V. 42, № 4. – P. 315–319.
29. Binding of ellipticine base and ellipticinium cation to calf-thymus DNA / G. Dodin, M.-A. Schwaller, J. Aubard, C. Paoletti // Eur. J. Biochem. – 1988. – V. 176, N 2. – P. 371–376.
30. Sartorius J. Intercalation mechanisms with ds-DNA: binding modes and energy contributions with benzene, naphthalene, quinoline and indole derivatives including some antimalarials / J. Sartorius, H.-J. Schneider // J. Chem. Soc., Perkin Trans 2. – 1997. – N 11. – P. 2319–2328.
2. Traganos F. Caffeine modulates the effects of DNA-intercalating drugs in vitro: A flow cytometric and spectrophotometric analysis of caffeine interaction with novantrone, doxorubicin, ellipticine, and the doxorubicin analogue AD198 / F. Traganos, J. Kapuściński, Z. Darzynkiewicz // Cancer Res. – 1991. – V. 51, № 14. – P. 3682–3689.
3. Piosik J. The modulation by xanthines of the DNA-damaging effect of polycyclic aromatic agents: Part II. The stacking complexes of caffeine with doxorubicin and mitoxantrone / J. Piosik, M. Zdunek, J. Kapuściński // Biochem. Pharmacol. – 2002. – V. 63, № 4. – P. 635–646.
4. Traganos F. Caffeine reverses the cytotoxic and cell kinetic effects of novantrone (mitoxantrone) / F. Traganos, B. Kaminska-Eddy, Z. Darzynkiewicz // Cell Prolif. – 1991. – V. 24, № 3. – P. 305–319.
5. Veselkov D.A. Molecular basis of the protective action of caffeine on the complexation of intercalating ligands with DNA / D.A. Veselkov, D.B. Davies, L.N. Djimant, A.N. Veselkov // Biopolym. Cell. – 2000. – V. 16, № 6. – P. 468–481.
6. Hetero-association of caffeine and aromatic drugs and their competitive binding with a DNA oligomer / D. B. Davies, D. A. Veselkov, L. N. Djimant, A. N. Veselkov // Eur. Biophys. J. – 2001. – V. 30, № 5. – P. 354–366.
7. 1H NMR analysis of the interaction of antibiotic mitoxantrone with DNA in the presence of caffeine in aqueous solution / A. N. Veselkov, S. A. Vysotsky, M. P. Evstigneev [et al.] // Biopolym. Cell. – 2002. – V. 18, № 4. – P. 287–296.
8. Davies D. B. NMR determination of the hetero-association of phenanthridines with daunomycin and their competitive binding to a DNA oligomer / D. B. Davies, D. A. Veselkov, A. N. Veselkov // Eur. Biophys. J. – 2002. – V. 31, № 2. – P. 153–162.
9. Pietrzak M. The “interceptor” properties of chlorophyllin measured within the three-component system: Intercalator-DNA-chlorophyllin / M. Pietrzak, Z. Wieczorek, J. Wieczorek, Z. Darzynkiewicz // Biophys. Chem. – 2006. – V. 123, № 1. – P. 11–19.
10. Attenuation of acridine mutagen ICR-191 — DNA interactions and DNA damage by the mutagen interceptor chlorophyllin / M. Pietrzak, H.D. Halicka, Z. Wieczorek [et al.] // Biophys. Chem. – 2008. – V. 135, № 1-3. – P. 69–75.
11. De-intercalation of ethidium bromide and propidium iodine from DNA in the presence of caffeine / J. Piosik, K. Wasielewski, A. Woziwodzka [et al.] // Cent. Eur. J. Biol. – 2010. – V. 5, № 1. – P. 59–66.
12. Evstigneev M. P. Complexation of daunomycin with a DNA oligomer in the presence of an aromatic vitamin (B2) determined by NMR spectroscopy / M. P. Evstigneev, Yu. V. Mykhina, D. B. Davies // Biophys. Chem. – 2005. – V. 118, № 2-3. – P. 118–127.
13. Evstigneev M. P. Complexation of norfloxacin with DNA in the presence of caffeine / M. P. Evstigneev, K. A. Rybakova, D. B. Davies // Biophys. Chem. – 2006. – V. 121, № 2. – P. 84–95.
14. Evstigneev M. P. Complexation of anthracycline drugs with DNA in the presence of caffeine / M. P. Evstigneev, V. V. Khomich, D. B. Davies // Eur. Biophys. J. – 2006. – V. 36, № 1. – P. 1–11.
15. Quantitation of the molecular mechanisms of biological synergism in a mixture of DNA-acting aromatic drugs / M. P. Evstigneev, A. O. Lantushenko, V. P. Evstigneev [et al.] // Biophys. Chem. – 2008. – V. 132, № 2-3. – P. 148–158.
16. Complexation of biologically active aromatic compounds with DNA in the presence of theophylline / A. A. Hernandez Santiago, D. D. Andrejuk, A.-M. Cervantes Tavera [et al.] // J. Biol. Phys. – 2009. – V. 35, № 2. – P. 115–126.
17. Quantification of the interceptor action of caffeine on the in vitro biological effect of the anti-tumour agent topotecan / M. P. Evstigneev, A. A. Mosunov, V. P. Evstigneev [et al.] // Eur. Biophys. J. – 2011. – V. 40, № 8. – P. 969–980.
18. General analysis of competitive binding in drug-interceptor-DNA systems / A. S. Buchelnikov, A. A. Hernandez Santiago, M. Gonzalez Flores [et al.] // Eur. Biophys. J. – 2012. – V. 41, № 3. – P. 273–283.
19. Протекторное действие витамина B2 по отношению к антибиотику топотекану in vitro / А. О. Лантушенко, А. А. Мосунов, З. Даржинкевич, М. П. Евстигнеев // Физика живого. – 2007. – Т. 15, № 2. – С. 18–23.
20. Antitumor effect of C60 fullerene in combination with doxorubicin / S. V. Prylutska, Yu. M. Kichmarenko, M. P. Evstigneev [et al.] // Cancer Nano (submitted).
21. Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline / J. Piosik, K. Ulanowska, A. Gwizdek-Wiśniewska [et al.] // Mutat. Res., Fundam. Mol. Mech. Mutagen. – 2003. – V. 530, № 1-2. – P. 47–57.
22. Formation of stacking complexes between caffeine (1,2,3-trimethylxanthine) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine may attenuate biological effects of this neurotoxin / K. Ulanowska, J. Piosik, A. Gwizdek-Wiśniewska, G. Węgrzyn // Bioorg. Chem. – 2005. – V. 33, № 5. – P. 402–413.
23. Methylxanthines (caffeine, pentoxifylline and theophylline) decrease the mutagenic effect of daunomycin, doxorubicin and mitoxantrone / J. Piosik, A. Gwizdek-Wiśniewska, K. Ulanowska [et al.] // Acta Biochim. Pol. – 2005. – V. 52, № 4. – P. 923–926.
24. Woziwodzka A. Caffeine, pentoxifylline and theophylline form stacking complexes with IQ-type heterocyclic aromatic amines / A. Woziwodzka, A. Gwizdek-Wiśniewska, J. Piosik // Bioorg. Chem. – 2011. – V. 39, № 1. – P. 10–17.
25. Dashwood R. Antimutagenic potency of chlorophyllin in the Salmonella assay and its correlation with binding constants of mutagen-inhibitor complexes / R. Dashwood, D. Guo // Environ. Mol. Mutagen. – 1993. – V. 22, № 3. – P. 164–171.
26. Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine / R. J. Turesky, S. C. Rossi, D. H. Welti [et al.] // Chem. Res. Toxicol. – 1992. – V. 5, № 4. – P. 479–490.
27. Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish / T. Sugimura, K. Wakabayashi, H. Nakagama, M. Nagao // Cancer Sci. – 2004. – V. 95, № 4. – P. 290–299.
28. On the reliability of quantitation of biological effect in drug-interceptor-DNA systems / A. S. Buchelnikov, V. P. Evstigneev, L. E. Rodríguez Oropeza, M. P. Evstigneev // Eur. Biophys. J. – 2013. – V. 42, № 4. – P. 315–319.
29. Binding of ellipticine base and ellipticinium cation to calf-thymus DNA / G. Dodin, M.-A. Schwaller, J. Aubard, C. Paoletti // Eur. J. Biochem. – 1988. – V. 176, N 2. – P. 371–376.
30. Sartorius J. Intercalation mechanisms with ds-DNA: binding modes and energy contributions with benzene, naphthalene, quinoline and indole derivatives including some antimalarials / J. Sartorius, H.-J. Schneider // J. Chem. Soc., Perkin Trans 2. – 1997. – N 11. – P. 2319–2328.
Cited
How to Cite
Buchelnikov, A. S., Rubakina, V. A., Mosunov, A. A., & Evstigneev, M. P. (1). Application of the theory of interceptor-protector action to in vitro biological experiment. Biophysical Bulletin, 2(30). Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/2321
Section
Methods of biophysical investigations
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