Application of the theory of interceptor-protector action to in vitro biological experiment

Authors

  • A. S. Buchelnikov Belgorod National Research University image/svg+xml Author
  • V. A. Rubakina Sevastopol National Technical University image/svg+xml Author
  • A. A. Mosunov Sevastopol National Technical University image/svg+xml Author
  • M. P. Evstigneev Sevastopol National Technical University image/svg+xml Author

Keywords:

hetero-association, DNA, interceptor action, mutagen, protector action

Abstract

The purpose of this paper is to ascertain whether the theory of interceptor-protector action (IPA) can be applied
to quantitation of the so far published data of biological experiments in vitro regarding the cases when differentDNA-binding ligands are administered simultaneously. The basic assumptions of the IPA theory were clearly formulated. Two different ways for estimation of biological effect were considered (viz. point estimation and estimation using concentration dependence of the AD factor). It was found that the IPA theory agrees with data from mutagenic test and the data from the experiment in proliferating cell lines

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Author Biographies

  • A. S. Buchelnikov, Belgorod National Research University

    85 Pobedy street, Belgorod 308015, Russia

  • V. A. Rubakina, Sevastopol National Technical University

    33 Universitetskaya street, Sevastopol 99053, Ukraine

  • A. A. Mosunov, Sevastopol National Technical University

    33 Universitetskaya street, Sevastopol 99053, Ukraine

  • M. P. Evstigneev, Sevastopol National Technical University

    33 Universitetskaya street, Sevastopol 99053, Ukraine

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Issue

Vol. 2 No. 30 (2013): Біофізичний вісник

Section

Methods of biophysical investigations

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How to Cite

Application of the theory of interceptor-protector action to in vitro biological experiment. (2015). Biophysical Bulletin, 2(30). https://periodicals.karazin.ua/biophysvisnyk/article/view/2321

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