Stochastic model for nmr analysis of multicomponent solutions of biologically active aromatic molecules
Keywords:
hetero-association, multicomponent solution, NMR, dynamic equilibrium
Abstract
A mathematical description of the N-component mixture of interacting aromatic molecules in an aqueous solution has been suggested with a possibility to compute the observed NMR proton chemical shift for each of the dissolved molecular components (N-STOCH model). On the basis of the N-STOCH model, a computer algorithm for the calculation of dynamic equilibrium in the multicomponent mixture has been developed and validated against the three-component mixture of antibiotic daunomycin, vitamin B2, and caffeine.
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References
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Traganos F, Kapuscinski J, Darzynkiewicz Z. Cancer Res. 1991;51:3682.
Bedner E, Du L, Traganos F, Darzynkiemicz Z. Cytomery. 2001;43:38.
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Wood AW, Sayer JM, Newmark HL, Yagi H, Michaud DP, Jerina DM, et al. Proc. Natl. Acad. Sci. USA. 1982;79:5122.
Raiczyk GB, Pinto J. Biochem. Pharm. 1988;37:1741.
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Larsen RW, Jasuja R, Hetzler R, Muraoka PT, Andrada VG, Jameson DM. Biophys. J. 1996;70:443.
Davies DB, Veselkov DA, Djimant LN, Veselkov AN. Eur. Biophys. J. 2001;30:354.
Davies DB, Djimant LN, Veselkov AN. J. Chem. Soc. Faraday Trans. 1996;92:383.
Ribeiro L, Carvalho RA, Ferreira DC, Veiga FJB. Eur. J. Pharm. Sci. 2005;24(1).
Evstigneev MP, Evstigneev VP, Hernandez Santiago AA, Davies DB. Eur. J. Pharm. Sci. 2006.
Evstigneev MP, Mykhina YuV, Davies DB. Biophys. Chem. 2005;118:118.
Evstigneev MP, Rybakova KA, Davies DB. Biophys. Chem. 2006.
Veselkov AN, Evstigneev MP, Rogoav OV, Chubarov AS, Devis DB. Biofizika. 2004;49:587. (in Russian)
Evstigneev MP, Davies DB, Veselkov AN. Chem. Phys. 2006;321:25.
Veselkov AN, Evstigneev MP, Veselkov DA, Davies DB. J. Chem. Phys. 2001;115:2252.
Iton RDzh,Veselko DA,Baranovskii SF, Osetrov SG, Dymant LN, Devis DB, et al. Khim. fizika. 2001;9:98. (in Russian)
Evstigneev MP, Rozvadovskaia AO, Chubarov AS, Ernandes Santiago AA, Devis DB, Veselkov AN. Zhurn. struktur. khimi. 2005;46:70. (in Russian)
Evstigneev MP, Rozvadovskaia AO, Ernandes Santiago aA, Mukhina IuV, Veselkov KA, et al. Fikz. khimiia. 2005;79:673. (in Russian)
Published
2005-06-06
Cited
How to Cite
Evstigneev, M. P., Evstigneev, V. P., & Shokurov, M. V. (2005). Stochastic model for nmr analysis of multicomponent solutions of biologically active aromatic molecules. Biophysical Bulletin, 2(16), 10-14. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/13286
Section
Molecular biophysics
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