Chlorpromazine interactions with lipid bilayers

  • V. M. Ioffe V.N. Karazin Kharkov National University
  • O. K. Zakharenko V.N. Karazin Kharkov National University
  • G. P. Gorbenko V.N. Karazin Kharkov National University
Keywords: lipid bilayer, chlorpromazine, Neutral Red, partition coefficient

Abstract

 The effect of cationic drug chlorpromazine (CPZ) on the structural state of model lipid membranes composed of zwitterionic phospholipid phosphatidylcholine (PC) and anionic phospholipid cardiolipin (CL) in molar ratios 8:2 and 3:2 has been investigated using the indicator dye Neutral Red (NR). CPZ incorporation into the PC/CL (8:2) liposomes led to the increase of NR partition coefficients. This effect was interpreted in terms of drug-induced membrane disordering. In contrast, CPZ association with PC/CL (3:2) lipid bilayers suppressed the dye partition which was assumed to be a result of lipid phase transition.

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Author Biographies

V. M. Ioffe, V.N. Karazin Kharkov National University

 4 Svobody Sq., Kharkov, 61077, Ukraine

O. K. Zakharenko, V.N. Karazin Kharkov National University

4 Svobody Sq., Kharkov, 61077, Ukraine

G. P. Gorbenko, V.N. Karazin Kharkov National University

4 Svobody Sq., Kharkov, 61077, Ukraine

References

Ueda I, Takehara K, Tamara T, Kamaya H. Progr. Anesth.Mech. 2002;7:18-23.

Hendrich AB, Michalak K. Current Drug Targets. 2003;4:23-30.

Hueck IS, Hollweg HG, Schmid-Schonbein GW, Artmann GM. Am. J. Physiol. Cell Physiol. 2000;278:873-8.

Cantor RS. Biochemistry. 1997;36:2339-44.

Batzri S, Korn E. Biochim. Biophys. Acta. 1973;298:1015-9.

Bartlett G. J. Biol. Chem. 1959;234:466-8.

Ivkov VG, Berestovsky GN. Dynamic structure of lipid bilayer. 1981.

Mayer LD, Bally MB, Hope MJ, Cullis PR. J. Biol. Chem. 1985;260:802-8.

Nerdal W, Gundersen SA, Thorsen V, Hoiland H, Holmsen H. Biochim. Biophys. Acta. 2000;1464:165-75.

Verkleij AJ, Maagd R, Leunissen-Bijvelt J. Biochim. Biophys. Acta. 1982;684:255-62.
Published
2006-06-05
Cited
How to Cite
Ioffe, V. M., Zakharenko, O. K., & Gorbenko, G. P. (2006). Chlorpromazine interactions with lipid bilayers. Biophysical Bulletin, 1(17), 54-57. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/12851
Issue
Vol. 1 No. 17 (2006): Біофізичний вісник
Section
Cell biophysics
Copyright (c) 2006 Biophysical visnik

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