Adaptive properties of influenza viruses isolated in Ukraine, at the limited use of antiviral drugs
Abstract
Today the important problem is an adaptation of influenza viruses to antiviral drugs, especially the neuraminidase inhibitors. In this study the presence of point mutations was investigated in the neuraminidase of influenza viruses isolated in the Ukraine in the epidemic season of 2011–2012 years and 2012–2013 years. For these influenza viruses, genes were sequenced and their genotypes were analysed. No replacements were found in the comparable positions of the amino acid sequences of influenza virus neuraminidase type A(H3N2) and A(H1N1)pdm, indicating that the Ukrainian isolates are sensitive to oseltamivir, zanamivir and peramivir. There were not detected the substitutions in the positions associated with the resistance to NAI in influenza viruses type B.
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