The effect of low-dose cadmium chloride on erythrocyte resistance to lysis and prooxidant-antioxidant status of blood and spleen of rats
Abstract
Cadmium chloride at a single administration to rats in a dose of 0.6 mg/kg of body weight caused a decrease in erythrocyte resistance to hypotonic and iron-induced lysis, which was accompanied by a decrease of the catalase and arginase activity in erythrocytes and the accumulation of bilirubin in serum. CdCl2 treatment in a dose of 1 mcg/kg/day during 29 days resulted in an increase of reduced glutathione content in erythrocytes and maintenance of their osmotic resistance at the control level. The concentration of hemolysis products in blood serum and TBARS in erythrocytes decreased under CdCl2 action in a dose of 0,6 mg/kg, including chronic treatment by CdCl2 in a dose of 1 mcg/kg/day. No changes of heme oxygenase activity in liver and spleen as well as concentration of TBARS and urea in blood serum were revealed under cadmium chloride action.
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