Fibril thermostability formed in vitro from collagen, synthesised in the skin under the effect of mechanical stretching
Abstract
The effect of mechanical stretching of the skin of rats, on oxidative deamination of lysine and hydroxylysine ε-NH2-group, as well as functional properties of the synthesized type I collagen in them, were studied in vitro. It was shown that the content of free ε-NH2-groups in the skin collagen that is synthesized under the effect of mechanical stretching is higher, and the level of molecular cross-linkage is lower than in collagen that is synthesized without the effect. As a result, fibrils formed from the first collagen, are shorter and less thermostable than those synthesized without mechanical stretching.
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