Сombine therapy of patients with acne vulgaris comorbidity with functional disorder of hepatobiliary system and demodecosis

doi:10.26565/2076-0612-2019-28-03

А. С. Радько Sumy State University, Ministry of Education and Science of Ukraine http://orcid.org/0000-0002-7673-9595
О. К. Мелеховець Sumy State University, Ministry of Education and Science of Ukraine http://orcid.org/0000-0001-9031-7009
Ю. В. Мелеховець Sumy State University, Ministry of Education and Science of Ukraine http://orcid.org/0000-0002-3219-9021
Т. О. Харченко Sumy State University, Ministry of Education and Science of Ukraine http://orcid.org/0000-0002-7690-2954

DOI: https://doi.org/10.26565/2076-0612-2019-28-03

Keywords: acne vulgaris, demodecosis, functional disorders of hepatobiliary system, laser eradiation, photodynamic therapy, physiotherapy

Abstract

Introduction. One of the common chronic dermatoses that have a direct impact on the quality of life of
patients is acne. The occurrence of psycho-emotional disorders due to the location of elements in the open areas
of the body. Given the high prevalence of acne in puberty (up to 85 % of adolescents have episodes of acne of varying severity), there is a need to find new algorithms for acne treatment to prevent the progression of social
maladaptation and depressive states.
Materials and methods. The study included 140 patients who were divided into 3 groups depending
on the presence of comorbid pathology and treatment methods: group 1 — patients with acne who were
underwent standard treatment for 60 days, group 2 — patients with acne in comorbidity with demodecosis,
group 3 — patients with acne in comorbidity with demodecosis and functional disorders of the digestive system,
who were additionally treated with a laser therapy. Treatment efficacy was evaluated using the GAGS scale and
the DLQI questionnaire on days 14, 28 and 60 of therapy.
Results. Evaluation of the results on day 60 shows a decrease in the manifestations of inflammation by 50 %
in groups 2 and 3, and by 29 % in the standard therapy group. Improving of the quality of life in groups 2 and 3
was by 70 %, while in the group 1 — by 35 %. The following correlations were established: r = + 0.9 — between the
severity of VC manifestations and the presence of comorbid pathology, r = + 0.71 — between the severity of VC
and the assessment of quality of life, r = + 0.69 — between the presence of acne comorbidity with demodecosis
and FDGBS and the effect on quality of life (p < 0.005).
Conclusions. Optimization of the treatment algorithm for acne patients in comorbidity with demodecosis
and functional disorders of the hepatobiliary system is achieved by the use of combined treatment using laser
therapy, which significantly improves the quality of life of patients.

Downloads

Download data is not yet available.

References

Thiboutot D, Dréno B, Abanmi A, Alexis AF, Araviiskaia E,

Barona Cabal MI et al. Practical management of acne for

clinicians: An international consensus from the Global Alliance

to Improve Outcomes in Acne. Journal of the American

Academy of Dermatology. 2018 Feb 1;78(2):1-23.

https://doi.org/10.1016/j.jaad.2017.09.078

Litwin D, Chen W, Dzika E, Korycinska J. Human Permanent

Ectoparasites; Recent Advances on Biology and

Clinical Significance of Demodex Mites: Narrative Review

Article. Iran J Parasitol. 27 Feb 2017;12(1):12-21.

Chen W, Plewig G. Human demodicosis: Revisit and a

proposed classification. Br J Dermatol. 2014;170(6):

–25. doi:10.1111/bjd.12850.

Karincaoglu Y, Tepe B, Kalayci B, Atambay M, Seyhan M. Is

Demodex folliculorum an aetiological factor in seborrhoeic

dermatitis? Clin Exp Dermatol. 2009 Dec;34(8):516-20.

Kubanov A, Gallyamova Y, Grevtseva A. Important aspects

of Demodex diagnostics. J Surg Dermatol. 2016;1(1):43–

http://dx.doi.org/10.18282/jsd.v1.i1.42.

Ruta Ganceviciene, Raimundas Meskauskas, Ausra

Berzanskyte. Treatment of Acne Vulgaris with 1064 nm

Nd:YAG Laser. J. LA&HA. 2015 June; Vol. 2015:1-5.

Pinto CD, Schafer F, Orellana JJ, González SR, Hasson A.

Efficacy of red light alone and methyl-aminolaevulinate-

photodynamic therapy for the treatment of mild

and moderate facial acne. Indian journal of dermatology,

venereology and leprology. 2013;79(1):77-82.

Luo X, Li W, Bird N, Chin SB, Hill NA, Johnson AG. On

the mechanical behavior of the human biliary system.

World J Gastroenterol. 2007 Mar 7;13(9):1384-92. doi:

3748/wjg.v13.i9.1384.

Radko A, Melekhovets O, Melekhovets Yu, Kharchenko T.

Epidemiology of acne vulgaris and its comorbidity with

demodicosis and functional dysorders of hepatobiliary.

Research Journal of Pharmaceutical,Biological and

Chemical Sciences (RJPBCS). 2019;10( 4):50-4. https://

doi.org/10.33887/rjpbcs/2019.10.4.

Melekhovec’ OK, Rad’ko AS, Smіyanov VA, Harchenko

TO, inventors. Sposіb dіagnostiki demodekozu z

vikoristannyam klejkoї strіchki [Method for the diagnosis

of demodicosis using adhesive tape]. Patent of Ukraine

№ 111590. 2016 Nov 10. (in Ukrainian)

Hazarika N, Rajaprabha RK. Assessment of Life Quality

Index Among Patients with Acne Vulgaris in a Suburban

Population. Indian J Dermatol. 2016;61(2):163–8.

doi:10.4103/0019-5154.177758.

Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin

HE, Berson DS, et al. Guidelines of care for the

management of acne vulgaris. J Am Acad Dermatol.

;74(5):945-73.

Melekhovec’ OK, Melekhovec’ YuV, Rad’ko AS, Harchenko

TO, , inventors. Sposіb lіkuvannya vugrovoї hvorobi z

vikoristannyam fotodinamіchnoї terapії [Method for the

treatment of acne using photodynamic therapy]. Patent

of Ukraine №126242. 2018 Jan 25. (in Ukrainian)

Robin Sult. Treatment of Acne Vulgaris with Long-

Pulsed 1064 nm Nd:YAG Laser. J Laser Health Acad.

;2014(1):57-60

Ganceviciene R, Meskauskas R, Berzanskyte A. Treatment

of Active Inflammatory Acne Vulgaris with

nm Nd:YAG Laser J LA&HA - J Laser Health Acad

;2015(1):S09.