New approaches to improve efficacy and reduce side effects of phototherapy for neonatal hyperbilirubinemia using led and laser sources

doi:10.26565/2076-0612-2019-26-08

В. Ю. Плавский Institute of Physics, National Academy of Sciences of Belarus http://orcid.org/0000-0002-7434-4530
Л. Г. Плавская Institute of Physics, National Academy of Sciences of Belarus http://orcid.org/0000-0003-0917-5977
Т. С. Ананич Institute of Physics, National Academy of Sciences of Belarus http://orcid.org/0000-0002-8329-1354
В. М. Катаркевич Institute of Physics, National Academy of Sciences of Belarus http://orcid.org/0000-0001-5740-1225
А. В. Микулич Institute of Physics, National Academy of Sciences of Belarus http://orcid.org/0000-0002-1159-3580
И. A. Леусенко Institute of Physics, National Academy of Sciences of Belarus http://orcid.org/0000-0002-7787-7439
А. И. Третьякова Institute of Physics, National Academy of Sciences of Belarus http://orcid.org/0000-0002-8454-216X
О. Н. Дудинова Institute of Physics, National Academy of Sciences of Belarus http://orcid.org/0000-0003-4251-503X
П. A. Мазманян Yerevan State Medical University http://orcid.org/0000-0002-8230-6534
В. В. Керопян Yerevan State Medical University
Г. Г. Маргарян Children’s University Clinic «Muratsan»

DOI: https://doi.org/10.26565/2076-0612-2019-26-08

Keywords: hyperbilirubinemia of the newborn, phototherapy, bilirubin, lumirubin, photoisomerization, LEDs, semiconductor lasers

Abstract

The article discusses the new opportunities for improving technology of phototherapy for neonatal jaundice using LED and laser sources in order to reduce the level of bilirubin in the blood of infants. It has been shown that several types of LEDs with emission spectrum corresponding to the long-wavelength slope of bilirubin absorption band can be used for therapeutic purposes. At the same time, the efficacy of phototherapy depend on not only from the position of the maximum in emission spectrum of the LEDs within bilirubin absorption band, but also on the spectral width of acting radiation. Based on the study of regularities of infl of optical radiation on the survival of animal cells in culture sensitized with bilirubin it has been concluded that the damaging eff cts are signifi ly reduced upon transition from quasi-monochromatic LED sources to lasers, emitting in the same spectral range. It allows to consider the modern semiconductor lasers emitting in blue and blue-green spectral regions as promising sources for development of phototherapeutic equipment for treating neonatal hyperbilirubinemia.

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