To question of increasing of efficiency of photodynamic therapy of tumors on the basis of multispectral treatment and diagnostic device

doi:10.26565/2076-0612-2018-25-06

В. В. Холин PSE «Photonica Plus» http://orcid.org/0000-0002-0232-0230
В. С. Войцехович Institute of Physics, NAS of Ukraine http://orcid.org/0000-0002-6143-2478
Р. В. Егоров PSE «Photonica Plus» http://orcid.org/0000-0002-6868-3288
В. И. Ивасенко PSE «Photonica Plus» http://orcid.org/0000-0001-8140-9374
Н. Т. Петраш PSE «Photonica Plus» http://orcid.org/0000-0002-5615-5816
Ю. А. Петрушко PSE «Photonica Plus» http://orcid.org/0000-0002-7116-5991
О. Н. Чепурная 1PSE «Photonica Plus» http://orcid.org/0000-0002-9942-5177
И. А. Штонь R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine http://orcid.org/0000-0002-9602-0457
С. В. Павлов Vinnytsia National Technical University http://orcid.org/0000-0002-0051-5560
Н. Ф. Гамалея R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine

DOI: https://doi.org/10.26565/2076-0612-2018-25-06

Keywords: photodynamic therapy, photosensitizer, fiber-optic channel, optical radiation, power density, oxygenation, fluorescence

Abstract

Damage to tumor cells as a result of photodynamic therapy is a multi-stage process, the effectiveness of which depends on a number of factors, and in particular on the properties of the photosensitizer used and the parameters of light irradiation of the tissues that it has colored. Nevertheless, the experience gained over decades of using photodynamic therapy in the clinic indicates a high heterogeneity of the tumor response to photodynamic therapy. Thus, there is an urgent need to create hardware complexes capable of real-time record- ing the effectiveness of photodynamic therapy monitoring by monitoring its key parameters, and, if possible, automatically adjust the scheme of the procedure, contributing to the creation of an individualized approach in the treatment of neoplasms.

The paper considers a method for increasing the efficiency of the photodynamic therapy method by devel- oping a prototype of such a diagnostic and treatment unit based on a combination of the principles of optical exposure and optical diagnostics. The device provides the possibility of non-invasive monitoring of the accu- mulation kinetics of photosensitizer in the tumor zone; determine the contrast of its accumulation relative to healthy tissues; control of tumor oxygenation at all stages of photodynamic therapy ; and also the effect on the tumor by optical radiation with a wavelength corresponding to the absorption peak used by the photosensitizer. From the values of these parameters, the course of the final cascade of cytotoxic and inflammatory reactions in the tumor and the mechanism of restoring damage after therapy are mainly dependent.

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