Phototherapeutic hardware complex for rehabilitation, prevention and treatment of diseases of the human central nervous system

Keywords: phototherapy hardware complex, brain diseases, prevention, treatment, rehabilitation, electromagnetic radiation of the optical range of the spectrum, LEDs, magnets

Abstract

Introduction. The significant prevalence of vascular diseases of the brain, the complexity of dysfunc- tion, put the problems of their treatment, rehabilitation and prevention into the focus of attention of modern neurology. A stroke occurs in the United States every 45 seconds. Approximately 750,000 people a year suffer from a stroke in the United States. According to statistics from the Ministry of Health of Ukraine, more than 110,000 primary strokes are recorded annually in the country. No less serious disease of the human central nervous system is Alzheimer’s disease. Each year, more than 500,000 Americans die from this disease, making it the third leading cause of death in the United States. Traffic accidents, local military conflicts, some sports form a very numerous specific group of patients with craniocerebral injuries.

Aim — to develop a phototherapeutic hardware complex for the prevention, treatment and rehabilitation of vascular, inflammatory, degenerative, post-traumatic and other brain diseases that are difficult amenable to medical treatment including pharmacoresistant indomitable pain syndromes.

Materials and methods. The low-intensity electromagnetic radiation of the optical range of the spectrum and the magnetic field of a permanent magnet are physical factors that are used in phototherapeutic complex devices.

Results. A phototherapy apparatus complex has been developed for the prevention, treatment and reha- bilitation of vascular, inflammatory, degenerative, post-traumatic and other brain diseases that are difficult to treat with drugs. The phototherapeutic hardware complex includes three devices: the modified photon-mag- netic apparatus Korobov-Posokhov “Barva-CNS/FM”, the photon-magnetic matrices A.Korobov - V.Korobov “Barva-Laryngologist/FM” and flexible photon-magnetic matrices A.Korobov - V.Korobov “Barva-Flex/24FM”. Conclusions. The presented clinical observations obtained using the developed phototherapeutic hard-ware complex for the treatment and prevention of diseases of the brain indicate high efficacy and safety of long-term low-intensity phototherapy in patients with dyscirculatory encephalopathy, with suffered ischemic and hemorrhagic strokes, with hypertensive disease.

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References

Boonswang NAb, Chicchi M, Lukachek A, Curtiss D. A new treatment protocol using photobiomodulation and muscle /bone/ joint recovery techniques having a dra- matic effect on a stroke patient’s recovery: a new weapon for clinicians. BMJ Case Reports. 2012. DOI:10.1136/ bcr.08.2011. 4689.

Sapon NA, Guk AP, Nikiforova AN, et al. Stroke. The realities and needs of providing neurosurgical care in Ukraine. Ukr. neyrohirurgich. jurnal [Ukr. neurosurg. journal]. 2013;4:43-8. (in Russian)

Samosyuk IZ, Samosyuk NI, Fedorov SN. Transcranial methods of physiotherapy in the medical rehabilitation of post-stroke patients Praktichna angiologiya. [Practical angiology]. 2010;5,6(34,35). (in Russian)

Lampl Y. Laser treatment for stroke. Expert Rev Neu- rotherapy. 2007;7:961-5.

Lampl Y, Ziviv JA, Fisher M. Infrared therapy for ischemic stroke: a new treatment strategy. Stroke. 2007;38:1843-9.

Hashmi JT, Huang Y, Sharma BZ, Naeser MA, Hamblin MR. Role of Low-Level Laser Therapy in Neuroreha- bilitation. PM R. Author manuscript; available in PMC 2011 Dec 1. PM R. 2010 December. 2 (12 Suppl 2): S292–S305. doi:10.1016/j.pmrj.2010.10.013.

Alz.org, 2016 Disease Facts and Figures.

Neurology March 5, 2014 [Epub ahead of print].

Time Magazine March 5, 2014.

Lim L. The Potential of Treating Alzheimer’s disease with Intranasal Light Therapy. Toronto: Medic Lights Research Inc. 2013

Hennessy M, Hamblin MR. Photobiomodulation and the brain: a new paradigm. J Opt. 2017 January;19(1): 013003–doi:10.1088/2040-8986/19/1/013003.

Maksimovich IV. Dementia and Cognitive Impairment Reduction after Laser Transcatheter Treatment of Alz- heimer’s Disease. World J Neurosci. 2015; 5.

Berman MH, Halper JP, Nichols TW, Jarrett H, Lundy A, Huang JH.

Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in Dementia Pa- tients Testing Memory and Cognition. J Neurol Neurosci. 2017; 8(1): doi:10.21767/2171-6625.1000176.

Naeser MA, Zafonte R, Krengel MH, Martin PI, Frazier J, Hamblin MR, Knight JA, Meehan WP 3rd, Baker EH. Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting di- ode treatments in chronic, mild traumatic brain injury: open-protocol study. J Neurotrauma. 2014;31:1008–17.

Naeser MA, Martins PI, Ho MD, Krengel MH, Bogdanova Y, Knight JA, Yee MK, Zafonte R, Frazier J, Hamblin MR, Koo BB. Transcranial, red/nearinfrared light-emitting diode therapy to improve cognition in chronic traumatic brain injury. Photomed Laser Surg. 2016;34(12):610–26.

Wu Q, Huang Y-Y, Dhital S, et al. Low level laser therapy for traumatic brain injury. SPIE Proc. 2010;7552:755206–8.

Maksimenko VA. Tipovyie narusheniya periferichesk- ogo krovoobrascheniya i mikrotsirkulyatsii. Uchebnoe posobie [Typical disorders of peripheral circulation and microcirculation. Study guide]. Blagoveschensk; 2013. (in Russian)

Litvitskiy PF. Patofiziologiya: ucheb. dlya vuzov [Patho- physiology: studies. for universities]. 4th ed., Moscow: GEOTAR-Media Publ; 2007. 496 p. .(in Russian)

Maslova MG, Chertok VM, editors. Nizkoenergeticheskie lazeryi v eksperimente i klinike [Low-energy lasers in experiment and clinic]. Vladivostok: Izdatelstvo Dal- nevostochnogo. universiteta Publ.; 1990. 248 p. .(in Russian)

Kozlov VI, Buylin VA, Samoylov NG, Markov II. Skobel- kina OK, editors. Osnovyi lazernoy fizio- i refleksoterapii [Basics of laser physio- and reflexotherapy]. Samara-Ki- ev; 1993. 216 p. (in Russian)

Gotovskiy YUV, Vyisheslavtsev AP, Kosareva LB, et al. Tsvetovaya svetoterapiya [Color light therapy]. Moscow: IMEDIS Publ; 2001. 432 p. (in Russian)

Konev SV, Volotovskiy ID. . Fotobiologiya [Photobiology]. Minsk: : Izdatelstvo BGU im. V.I.Lenina Publ; 1979. 383 p.(in Russian)

Vladimirov YuA, Osipov AN, Klebanov GI. Photobiologi- cal basis of therapeutic use of laser irradiation. Biohimiya [Biochemistry]. 2004;69(1):103–13. (in Russian)

Kaminskiy AV. The use of laser radiation as a stimulating factor of proliferative processes in bone grafting defects. In: . Materialyi XXIII Mejdunarodnoy nauchno-prak- ticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXIII International Scientif- ic and Practical Conference. The use of lasers in medicine and biology]; 2005 May 25–28; Nikolaev. Kharkov: NPMBK “Laser and Health” Publ; 2005, p. 31–32. (in Russian)

Tondiy LD, Korobov AM. The use of the Korobov pho- ton matrix “Barva-Flex / K” to stimulate physiologi- cal measures to protect the body. In: Materialyi XVI Mejdunarodnoy nauchno-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Materials of the XVI International Scientific and Practical Confer- ence. The use of lasers in medicine and biology]; 2001 Sept 25–28; Theodosius. Kharkov: NPMBK Laser and Health Publ; 2001, p. 28-29. (in Russian)

Posohov NF, Kozyir EV, Korobov AM, Chernenkov VG, Serbinenko IA. The Korobov-Posokhov apparatus for phototherapy of diseases of the central nervous system “Barva-CNS”. Fotobiologiya i Fotomeditsina [Photobiolo- gy and Photomedicine]. 2007;5(3,4):109-15. (in Russian)

Ulaschik VS, editor et al. Minsk: : Belaruskaya navuka Publ; 2015. 379 p. (in Russian)

Korobov AM. About photoluminescence of biological objects under the action of low-intensity electromagnetic radiation of the visible spectrum. In: Materialyi XXXXІ Mejdunarodnoy nauchno-prakticheskoy konferentsii. Primeneniya lazerov v meditsine i biologii [Proceedings of the XXXXI International Scientific Practical Confer- ence. The use of lasers in medicine and biology]; 2014 May 28-31; Kharkiv. Kharkiv: NPMBK Laser and Health Publ; p. 8-11. (in Russian)

Korobov AM, Korobov VA. Photon-magnetic matrices Ko- robov A. - Korobov V. “Barva-Flex/FM24”. Fotobiologiya i Fotomeditsina [Photobiology and Photomedicine]. 2012;9(1,2):132-42. (in Russian)

Grigorova IA, Eskin AR, Nekrasova NA. The rationale for the use of the matrix “Barva-Flex” in patients with dyscirculatory encephalopathy. In: Materialyi XXV Mejdunarodnoy nauchno-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXV International Scientific and Practical Confer- ence. The use of lasers in medicine and biology]; 2006 May 24–28; Lutsk. Kharkiv: NPMBK Laser and Health Publ; 2006, p. 20–1. (in Russian)

Tondiy LD, Lesnaya TA, Zhuravlev VA, et al. Experience of using the Korobov Barva-Flex photon matrices to nor- malize blood pressure. In: Materialyi XXVІ Mejdunarod- noy nauchno-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXVІ International Scientific and Practical Conference. The use of lasers in medicine and biology]; 2006 Oct 11–14; Yalta. Kharkov: NPMBK Laser and Health Publ; 2006; p. 37–8. (in Russian)

Tondiy LD, Lesnaya TA, Zhuravlev VA, et al. The role of phototherapy in the rehabilitation of post-infarction patients. In: Materialyi XXVІІІ Mejdunarodnoy nauch- no-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXVIII Inter- national Scientific and Practical Conference. The use of lasers in medicine and biology]; 2007 October 21–24; Yalta. Kharkov: NPMBK Laser and Health Publ; 2007, p. 53–5. (in Russian)

Gorbunova EM, Zasimskaya VA. Application of pho- totherapy methods in the complex sanatorium-resort treatment of patients with chronic obstructive pul- monary diseases. In: Materialyi XXX Mejdunarod- noy nauchno-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXX International Scientific and Practical Conference. The use of lasers in medicine and biology]; 2008 Oct 8–11; Yalta. Kharkov: NPMBK Laser and Health Publ; 2008, p. 165–6. (in Russian)

Poteyko PI, Korobov AM, Korobov VA. The effectiveness of magnetic laser therapy in patients with pulmonary tu- berculosis according to acupuncture diagnostics. In: Ma- terialyi XXVII Mejdunarodnoy nauchno-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXVII International Scientific and Practical Conference. The use of lasers in medicine and biology]; 2007 Apr 18–21; Kharkov. Kharkov: NPMBK Laser and Health Publ; 2007. p. 53–4. (in Russian)

Gradil GI, Kozko VN, Chorna TT, Merkulova NF, Mogile- nets EI. Study of non-monochromatic infrared and visible radiation effectiveness in the complex treatment of community-acquired pneumonia in infectious dis- ease hospital. In: Materialyi XXXVII Mejdunarodnoy nauchno-prakticheskoy konferentsii. Primenenie laze- rov v meditsine i biologii [Proceedings of the XXXVII International Scientific Practical Conference. The use of lasers in medicine and biology]; 2012 Aug 24–29; Helsinki. Kharkov: VN Karazin KhNU Publ; 2012, p. 11. (in Russian)

Ashurov ShE, Baybekov IM. Morphological substantia- tion of the choice of types and methods of phototherapy in the complex treatment and prevention of perfora- tion of gastroduodenal ulcers. In: Materialyi XXXXI Mejdunarodnoy nauchno-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXXXI International Scientific Practical Confer- ence. The use of lasers in medicine and biology]; 2014 May 28-31; Kharkov. Kharkov: VN Karazin KhNU Publ; 2014, p. 54–5. (in Russian)

Baybekov IM, Kabulov MK, Butaev AKh. The possibili- ties of using phototherapy in the treatment of the main complications of peptic ulcer disease (morphological aspects). In: Materialyi XXXXI Mejdunarodnoy nauch- no-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXXXI Inter- national Scientific and Practical Conference. The Use of Lasers in Medicine and Biology]; 2014 May 28-31; Kharkov. Kharkov: VN Karazin KhNU Publ, 2014, p. 55–6. (in Russian)

Scherbatska OO. Eff eness of the Korobov photon matrix Korobov Barva-Flex/ JІK with corrective power systems. In: Materialyi XXVIII Mejdunarodnoy nauch- no-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXVIII Inter- national Scientific and Practical Conference. Use of Lasers in Medicine and Biology]; 2007 Oct 21–24; Yalta. Kharkov: NPMBC Laser and Health Publ; 2007; p. 42–3. (in Russian)

Baklikov OL, Zabelin VG,. Chernyaev AL. Laser therapy of spinal osteochondrosis, accompanied by spondylolis- thesis with severe pain syndrome. In: Materialyi XXV Mejdunarodnoy nauchno-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXV International Scientific and Practical Con- ference. Application of lasers in medicine and biology]; 2006 May 24–28; Lutsk. Kharkiv: NPMBK Laser and Health Publ; 2006; p. 10. (in Russian)

Zhuravleva LV, Fedorov VA, Alexandrova NK. Application of phototherapy in patients with articular syndrome. In: Materialyi XXXVIII Mejdunarodnoy nauchno-prak- ticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXXVIII International Scientific and Practical Conference. The Use of Lasers in Medicine and Biology]; 2012 Oct 3–6; Yalta. Kharkov: VN Karazin KhNU Publ; 2012; p. 30–1. (in Russian)

Tondiy LD, Kas IV, Tondiy OL. The use of photon matrices Korobov “Barva-Flex” in the treatment of chronic pain syndrome in patients with vertebral osteochondrosis. In: Materialyi XXI Mejdunarodnoy nauchno-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXI International Scientific and Prac- tical Conference. Application of lasers in medicine and biology]; 2004 May 26–29; Odessa. Kharkov: NPMBK Laser and Health Publ; 2004; p. 62–3. (in Russian)

Zhigarev YuA. Laser therapy of encephalitis of herpetic etiology. In: Materialyi XVII Mejdunarodnoy nauch- no-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XVII Interna- tional Scientific and Practical Conference. Application of lasers in medicine and biology]; 2002 May 21–23; Kharkov. Kharkov: NPMBK Laser and Health Publ; 2002; p. 32–3. (in Russian)

Zhigarev YuO. Prospects for low-intensity laser imaging in the complex neuroinfection. In: Materialyi XXV Mejdunarodnoy nauchno-prakticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the XXV International Scientific and Practical Con- ference. Application of lasers in medicine and biology]; 2006 May 24–28; Lutsk. Kharkov: NPMBK Laser and Health Publ; 2006; p. 28–30. (in Russian)

Muliar OS. Prevention of acute respiratory viral infection in the minds of the child sanatorium using light. In: Ma- terialyi yubileynoy XX Mejdunarodnoy nauchno-prak- ticheskoy konferentsii. Primenenie lazerov v meditsine i biologii [Proceedings of the jubilee XX International Scientific and Practical Conference. Application of la- sers in medicine and biology]; 2003 Oct 8–11; Yalta. Kharkov: NPMBC Laser and Health Publ; 2003; p. 53. (in Ukrainian)

Kovbasyuk DV, Chepela NV, Danilchuk AO, Prisyazhnyuk NV. Experience of using photon matrices in the complex treatment of vascular diseases of the brain. In: Materials XLIX International Scientific and Practical Conference. Application of lasers in medicine and biology and 2nd Gamaleia’s Readings; 2018 Oct 3-7; Hajduszoboszlo. Kharkov: Petrov Publ; 2018; p. 122-4. (in Ukrainian)

Filipovska DI, Neduraieva IV, Kosman VA, Shevchenko NI. Experience of light treatment of cerebral circulatory disorders in the conditions of the territorial social service center. In: Materialyi XLVIII Mejdunarodnoy nauch- no-prakticheskoy konferentsii. Zastosuvannya lazerіv v meditsine i biologii [Materials XLVIII International Scientific and Practical Conference. Application of lasers in medicine and biology]; 2018 May 24-25; Kharkiv. Kharkiv: Petrov Publ; 2018; p. 98-100. (in Ukrainian)

Zakutіy MM, Marchuk TA, Fіlіpovska DІ. Improving the technology of light therapy of the cerebral blood circulation disorders in the conditions of the territorial social service center. In: Materials XLIX International Scientific and Practical Conference. Application of lasers in medicine and biology and 2nd Gamaleia’s Readings; 2018 Oct 3-7; Hajduszoboszlo. Kharkiv: Petrov Publ; 2018, p. 24-6. (in Ukrainian)

Posokhov NF, Korobov AM, Makarov VN, Vorobyev VV, Kostyukovskaya AE,. Nazarchuk AG, et al. Successful treatment of dyscirculatory encephalopathy using the Korobov-Posokhov photon matrix Barva-CNS/PH (case study). In: Materіali XLII Mіjnarodnoi naukovo-prak- tichnoi konferentsіi. Zastosuvannya lazerіv u meditsinі ta bіologіi [Materials XLII International Scientific and Practical Conference. Application of lasers in medicine and biology]; 2014 Des 11-13; Yaremche. Kharkiv: Petrov Publ; 2014; p. 43-5. (in Russian)

Published
2018-12-09
How to Cite
KorobovА. М., Posokhov, M. F., Korobov, V. A., & Kozyr, O. V. (2018). Phototherapeutic hardware complex for rehabilitation, prevention and treatment of diseases of the human central nervous system. Photobiology and Photomedicine, 15(1(24), 75-85. https://doi.org/10.26565/2076-0612-2018-24-09
Section
Photobiology and experimental photomedicine