Низькоінтенсивна лазерна терапія в реабілітації хворих на ішемічну хворобу серця: огляд доказових досліджень
Анотація
Вступ. Кардіореабілітація є одним з головних досягнень кардіології та фізичної реабілітаційної
медицини другої половини 20-го століття. Заснована на методології доказової медицини, кардіореа-
білітація за короткий час еволюціонувала від «вигаданого» «альтернативного» бездоказово лікуваль-
ного напряму до абсолютно безальтернативних багатопрофільних програм, що довели свою безумовну
ефективність. У статті представлені сучасні дані про реабілітацію хворих на ішемічну хворобу серця та
аналіз доказових експериментальних і клінічних досліджень про ефективність застосування низькоін-
тенсивної лазеротерапії.
Мета — пошук доказових досліджень щодо застосування низькоінтенсивної лазеротерапії
у реабілітації хворих на ішемічну хворобу серця та аналіз їх основних положень і рекомендацій.
Матеріал і методи. Стратегія пошуку доказових досліджень включала пошук рандомізованих клініч-
них досліджень, систематичних оглядів, мета-аналізів і клінічних протоколів за ключовими словами в
електронних базах публікацій з доказової фізіотерапії PEDro, EMBASE, PubMed і «Cochrane library» за
2000–2019 рр.
Результати та обговорення. Детально розглянуті експериментальні і клінічні дослідження,
проаналізовані дані про механізми дії низькоінтенсивної лазеротерапії, її позитивний вплив на процеси
ремоделювання міокарда, зменшення зони інфаркту, профілактики рестенозу і надання кардіозахисного
ефекту. Велику увагу приділено клінічним доказовим дослідженням щодо застосування фотобіомодуляціі
для підвищення ефективності хірургічної реваскуляризації міокарда, а також в неінвазивній кардіології
та фізичній реабілітаційній медицині.
Висновок. Необхідний регулярний аналіз проведених та проведення нових доказових досліджень з
вивчення ефективності застосування низькоінтенсивної лазеротерапії в реабілітації хворих на ішемічну
хворобу серця.
Завантаження
Посилання
Аbreu A. Hot topics in cardiac rehabilitation. Dialogues
cardiovasc med. 2017;22(3):21-3.
Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H,
Rees K. Exercise-based rehabilitation for patients with
coronary heart disease: systematic review and meta-
analysis of randomized controlled trials. Am J Med.
;116(10):682-92.
Smith SC Jr, Benjamin EJ, Bonow RO, Braun LT, Creager
MA, Franklin BA, et al. AHA/ACCF secondary prevention
and risk reduction therapy for patients with coronary
and other atherosclerotic vascular disease: 2011 update:
a guideline from the American Heart Association and
American College of Cardiology Foundation. Circulation2011;
(22):2458–73.
Niebauer J, Velich T, Hambrecht DR. 6 years of intensive
physical exercise and low-fat diet: effects on progression
of coronary artery disease. Circulation 1995;92(1):398.
Giudice R, Izzo R, Manzi MV, Pagnano G, Santoro M,
Rao MA, et al. Lifestyle-related risk factors, smoking
status and cardiovascular disease. High Blood Press
Cardiovasc Prev. 2012;19(22):85-92.
Mozaffarian D, Fahimi S, Singh GM, Micha R, Khatibzadeh
S, Engell RE, et al. Global Burden of Diseases Nutrition
and Chronic Diseases Expert Group. Global sodium
consumption and death from cardiovascular causes. N
Engl J Med. 2014;371(7):624−34.
Schuler G, Hambrecht R, Schliert G. Regular physical exercise
and low-fat diet. Effects on progression of coronary
artery disease. Circulation 1992;86(1):1-11.
Pasquali SK, Alexander KP, Coombs LP, Lytle BL, Peterson
ED. Effect of cardiac rehabilitation on functional
outcomes after coronary revascularization. Am Heart J.
;145(3):445-51.
Aronov DM, Bubnova MG, Ivanova GE. [Organizational
basis of cardiological rehabilitation in Russia: the modern
stage]. Cardio Somatica. 2012;4:5-11. (in Russian)
Aronov DM, Krasnickij VB, Bubnova MG, Pozdnyakov
YuM, Ioseliani DG, Shchegol’kov AN et al. [The effect
of physical training on physical performance, hemodynamics,
blood lipids, clinical course and prognosis in
patients with coronary heart disease after acute coronary
events with complex rehabilitation and secondary prevention
at the outpatient stage (Russian cooperative study)].
Kardiologiya [Cardiology]. 2009;3:49-56. (in Russian)
Belardinelli R, Paolini I, Cianci G. Exercise training intervention
after coronary angioplasty: the ETICA trial.
J Am Coll Cardiol. 2001;37(7):1891-900.
Hambrecht R, Walther C, Möbius-Winkler S, Gielen
S, Linke A, Conradi K, et al. Percutaneous coronary
angioplasty compared with exercise training in patients
with stable coronary artery disease: a randomized trial.
Circulation 2004;109(11):1371-8.
Smith SC Jr, Allen J, Blair SN, Bonow RO, Brass LM,
Fonarow GC, et al. АНА/АСС Guidelines for Secondary
Prevention for Patients With Coronary and Other Atherosclerotic
Vascular Diseases: 2006 Update. J Am Coll
Cardiol 2006;47(10):2130-9.
Wijns W, Kolh P, Danchin N, Di Mario C, Falk V, Folliguet
T, et al. Guidelines on myocardial revascularization:
The Task Force on Myocardial Revascularization of the
European Society of Cardiology (ESC) and the European
Association for Cardio-Thoracic Surgery (EACTS). Eur
Heart J. 2010;31(20):2501–55.
Amirov NB. [Low-intensity laser radiation in the treatment
of coronary heart disease]. Fundamental’nye issledovaniya
[Basic research]. 2008;5:14-6. (in Russian)
Amirov NB, Abdrahmanova AI. [The use of low-intensity
laser radiation in the complex treatment of coronary heart
disease]. Rossijskij kardiologicheskij zhurnal [Russian
Journal of Cardiology]. 2002;5:24-7. (in Russian)
Volotovskaya AG, Ulashchik VS, Filipovich VT. [Antioxidant
effect and therapeutic efficacy of laser blood
irradiation in patients with coronary heart disease]. Vopr.
kurort. fizioter. LFK [Q. resort. fizioter. exercise therapy].
;3:22-5. (in Russian)
Vasil’ev AV, Sekisova MN, Strel’cova NF, Senatorov II.
[Laser correction of microcirculation disorders in patients
with coronary artery disease with hypercholesterolemia].
Klin Med [Clin. Med.]. 2005;2:33-7. (in Russian)
Doncov AV. [Low-intensity laser radiation in the treatment
of patients with coronary artery disease with
metabolic syndrome (literature review)]. Vestnik novyh
medicinskih tekhnologij [Bulletin of new medical technologies].
;19(4):144-6. (in Russian)
Kemalov RN. [The effect of low-intensity laser radiation
on lipid metabolism and hemostasis in patients with myocardial
infarction]. Vopr. kurort, fizioter, LFK [Questions
of resort, physiotherapist, exercise therapy]. 2006;2:6-8.
(in Russian)
Moskvin SV. Effektivnost’ lazernoj terapii. Seriya “Effektivnaya
lazernaya terapiya” [The effectiveness of
laser therapy. Series “Effective Laser Therapy”]. V. 2.
Moscow-Tver: Triada Publ.; 2014. 251 p. (in Russian)
Nikitin AV, El’zhurkaev AA.[ Ultravascular low-intensity
laser radiation in the complex treatment of coronary heart
disease]. Vestnik novyh medicinskih tekhnologij [Bulletin
of new medical technologies]. 2013;1:15-21. (in Russian)
Popov VD, editor. Sovremennye aspekty lazernoj terapii
[Modern aspects of laser therapy]. Cherkasy: Vertikal’,
Kandych S.G. Publ.; 2011. 231 p. (in Russian)
Loboda MV, Babov KD, Zolotar’ova TA, Grіnyaєva LYa,
editors. Standarti (klіnіchnі protokoli) sanatorno-kurortnogo
lіkuvannya [Standards (clinical reports) of the
sanatorium resort]. 2008. 416 p. (in Russian)
Duarte FO, Sene-Fiorese M, de Aquino Junior AE, da
Silveira Campos RM, Masquio DC, Tock L, et al. Can
low-level laser therapy (LLLT) associated with an aerobic
plus resistance training change the cardiometabolic
risk in obese women? A placebo-controlled clinical trial.
J Photochem Photobiol B. 2015;153:103-10.
Mandel A, Hamblin MR. A renaissance in low-level
laser (light) therapy–LLLT. Photonics Lasers Med.
;1(4):231–4.
Liebert A, Krause A, Goonetilleke N, Bicknell B, Kiat H.
A Role for Photobiomodulation in the Prevention of
Myocardial Ischemic Reperfusion Injury: A Systematic
Review and Potential Molecular Mechanisms. Sci Rep.
;7:42386.
Lyubimov AV, Shabanov PD. [Ischemia, reperfusion and
new approaches in the treatment of myocardial infarction].
Obzory po klinicheskoj farmakologii i lekarstvennoj
terapii [Clinical pharmacology and drug therapy reviews].
;3:3-9. (in Russian)
Yang J, Huang Z, Zhou Y, Sai S, Zhu F, Lv R, et al. Effect
of low-level laser irradiation on oxygen free radicals and
ventricular remodeling in the infarcted rat heart. Photomed
Laser Surg. 2013;31:447–52.
Quirk BJ, Sonowal P, Jazayeri MA, Baker JE, Whelan HT.
Cardioprotection from ischemia-reperfusion injury
by nearinfrared light in rats. Photomed. Laser Surg.
;32:505–11.
Oron U, Yaakobi T, Oron A, Mordechovitz D, Shofti R,
Hayam G, et al. Low-energy laser irradiation reduces
formation of scar tissue after myocardial infarction in
rats and dogs. Circulation 2001;103:296–301.
Keszler A, Baumgardt S, Hwe C, Bienengraeber M. Far
red/near infrared light-induced cardioprotection under
normal and diabetic conditions. Proc. SPIE 9309, Mechanisms
for Low-Light Therapy X, 93090P.
Keszler A, Brandal G, Baumgardt S, Ge ZD, Pratt PF,
Riess ML, et al. Far red/near infrared light-induced protection
against cardiac ischemia and reperfusion injury
remains intact under diabetic conditions and is independent
of nitric oxide synthase. Front Physiol. 2014;5:305.
Gatsura S, Gladkikh S, Titov M. Effect of low-energy
laser irradiation on the area of experimental myocardial
infarction, lipidperoxidation, and hemoglobin affinity for
oxygen. B Exp Biol Med. 2004;137:355–7.
Yang Z, Wu Y, Zhang H, Jin P, Wang W, Hou J, et al.
Low-level laser irradiation alters cardiac cytokine expression
following acute myocardial infarction: a potential
mechanism for laser therapy. Photomed Laser Surg.
;29:391–8.
Yaakobi T, Shoshany Y, Levkovitz S, Rubin O, Ben
Haim SA, Oron U. Long-term effect of low energy laser
irradiation on infarction and reperfusion injury in the rat
heart. J Appl Physiol. 2001;90:2411–9.
Tuby H, Maltz L, Oron U. Modulations of VEGF and iNOS
in the rat heart by low level laser therapy are associated
with cardioprotection and enhanced angiogenesis. Laser
Surg Med. 2006;38:682–8.
Tuby H, Maltz L, Oron U. Induction of autologous mesenchymal
stem cells in the bone marrow by low-level laser
therapy has profound beneficial effects on the infarcted
rat heart. Laser Surg Med. 2011;43:401–9.
Ad N, Oron U. Impact of low level laser irradiation on
infarct size in the rat following myocardial infarction. Int
J Cardiol. 2001;80:109–16.
Lohr NL, Keszler A, Pratt P, Bienengraber M, Warltier
DC, Hogg N. Enhancement of nitric oxide release from
nitrosyl hemoglobin and nitrosyl myoglobin by red/near
infrared radiation: potential role in cardioprotection.
J Mol Cell Cardiol. 2009;47:256–63.
Manchini MT, Serra AJ, Feliciano Rdos S, Santana ET,
Antônio EL, de Tarso Camillo de Carvalho P, et al.
Amelioration of cardiac function and activation of anti-
inflammatory vasoactive peptides expression in the
rat myocardium by low level laser therapy. PloS One
;9:e101270.
Carlos FP, Gradinetti V, Manchini M, de Tarso Camillo
de Carvalho P, Silva JA Jr, Girardi ACC, et al. Role of
low-level laser therapy on the cardiac remodeling after
myocardial infarction: A systematic review of experimental
studies. Life Sci. 2016;151:109-14.
Mirsky N, Krispel Y, Shoshany Y, Maltz L, Oron U. Promotion
of angiogenesis by low energy laser irradiation.
Antioxid Redox Signal. 2002;4(5):785-90.
Oron U. Photoengineering of tissue repair in skeletal and
cardiac muscles. Photomed Laser Surg. 2006;24(2):111-20.
Blatt A, Elbaz-Greener GA, Tuby H, Maltz L, Siman-Tov Y,
Ben-Aharon G, et al. Low-Level Laser Therapy to the Bone Marrow Reduces Scarring and Improves Heart Function
Post-Acute Myocardial Infarction in the Pig. Photomed
Laser Surg. 2016;34(11):516-24.
Derkacz A, Protasiewicz M, Poreba R, Szuba A, Andrzejak
R. Usefulness of intravascular low power laser
illumination in preventing restenosis after percutaneous
coronary intervention. Am J Cardiol. 2010;106:1113–7.
De Scheerder IK, Wang K, Nikolaychik V, Kaul U, Singh B,
Sahota H, et al. Long-term follow-up after coronary stenting
and intravascular red laser therapy. Am. J. Cardiol.
;86:927–30.
De Scheerder IK, Wang K, Kaul U, Singh B, Sahota H,
Keelan MH, et al. Intravascular low-power laser irradiation
after coronary stenting: Long-term follow-up. Laser
Surg Med. 2001;28:212–5.
Salem M, Rotevatn S, Nordrehaug JE. Long-term results
following percutaneous myocardial laser therapy. Coron
Artery Dis. 2006;17:385–90.
Lima AC, Fernandes GA, de Barros Araújo R, Gonzaga IC,
de Oliveira RA, Nicolau RA. Photobiomodulation (laser
and LED) on sternotomy healing in hyperglycemic and
normoglycemic patients who underwent coronary bypass
surgery with internal mammary artery grafts: A randomized,
double-blind study with follow-up. Photomed Laser
Surg. 2017;35(1):24-31.
Karu T. Mitochondrial signaling in mammalian cells
activated by red and near-IR radiation. Photochem Photobiol.
;28:1091–9.
Hüttemann M, Helling S, Sanderson TH, Sinkler C,
Samavati L, Mahapatra G, et al. Regulation of mitochondrial
respiration and apoptosis through cell signaling:
cytochrome c oxidase and cytochrome c in ischemia/
reperfusion injury and inflammation. Biochim Biophys
Acta. 2012;1817(14):598–609.
Heusch G. Molecular basis of cardioprotection signal
transduction in ischemic pre-, post-, and remote conditioning.
Circ Res. 2015;116:674–99.
Hu Y, Zhang H, Lu Y, Bai H, Xu Y, Zhu X, et al. Class A
scavenger receptor attenuates myocardial infarction-induced
cardiomyocyte necrosis through suppressing
M1macrophage subset polarization. Basic Res Cardiol.
;106:1311–28.
Gao X, Xing D. Molecular mechanisms of cell proliferation
induced by low power laser irradiation. J Biomed
Sci. 2009;16:4.
Zhang H, Xing D, Wu S, Sun X. Protein kinase C δ promotes
cell apoptosis induced by high fluence low-power
laserirradiation. Proc. SPIE 7519, Eighth International
Conference on Photonics and Imaging in Biology and
Medicine (PIBM 2009), 751919.
Hsieh YL, Chou LW, Chang PL, Yang CC, Kao MJ,
Hong CZ. Low-level laser therapy alleviates neuropathic
pain and promotes function recovery in rats with
chronic constriction injury: Possible involvements in
hypoxia-inducible factor 1α (HIF-1α ). J Comp Neurol.
;520:2903–16.
Zyciński P, Krzemińska-Pakuła M, Peszyński-Drews C,
Kierus A, Trzos E, Rechciński T, Figiel L, Kurpesa M,
Plewka M, Chrzanowski L, Drozdz J. Laser biostimulation
in end-stage multivessel coronary artery disease-a preliminary
observational study. Kardiol Pol. 2007;65(1):13-
; discussion 22-3.
Boden WE, O’Rourke RA, Teo KK, Hartigan PM, Maron
DJ, Kostuk WJ, et al. Optimal medical therapy with
or without PCI for stable coronary disease. N Engl J Med.
;356(15):1503–16.
Katritsis DG, Ioannidis JP. Percutaneous coronary
intervention versus conservative therapy in non-acute
coronary artery disease: a meta-analysis. Circulation
;111(22):2906–12.
Kaul U, Singh B, Sudan D, Ghose T, Kipshidze N. Intravascular
red light therapy after coronary stenting—angiographic
and clinical follow-up study in humans. J Invas
Cardiol. 1998;10:534–8.
Derkacz A, Protasiewicz M, Poręba R, Doroszko A, Andrzejak
R. Effect of the intravascular low energy laser
illumination during percutaneous coronary intervention
on the inflammatory process in vascular wall. Lasers Med
Sci. 2013;28(3):763-8.
Derkacz A, Protasiewicz M, Rola P, Podgorska K,
Szymczyszyn A, Gutherc R, et. al. Effects of intravascular
low-level laser therapy during coronary intervention
on selected growth factors levels. Photomed Laser Surg.
;32(10):582-7.
Derkacz A, Szymczyszyn A, Szahidewicz-Krupska E,
Protasiewicz M, Poręba R, Doroszko A. Effect of endovascular
coronary low-level laser therapy during angioplasty
on the release of endothelin-1 and nitric oxide. Adv Clin
Exp Med. 2017;26(4):595-9.
Fernandes GA, Araújo Júnior RB, Lima AC, Gonzaga
IC, de Oliveira RA, Nicolau RA. Low-intensity Laser
(660 nm) has Analgesic Effects on Sternotomy of Patients
Who Underwent Coronary Artery Bypass Grafts. Ann
Card Anaesth. 2017; 20(1): 52–6.
Lima AC, Fernandes GA, Gonzaga IC, de Barros Araújo
R, de Oliveira RA, Nicolau RA. Low-level laser and
light-emitting diode therapy for pain control in hyperglycemic
and normoglycemic patients who underwent
coronary bypass surgery with internal mammary artery
grafts: A randomized, double-blind study with follow-up.
Photomed Laser Surg. 2016;34:244–51.
Huang AP, Sakata RK. Pain after sternotomy – Review.
Rev Bras Anestesiol. 2016;66:395–401.
Aras MH, Omezli MM, Güngörmüs M. Does low-level
laser therapy have an antianesthetic effect? A review.
Photomed Laser Surg. 2010;28:719–22.
de Oliveira RA, Fernandes GA, Lima AC, Tajra Filho AD,
de Barros Araújo R Jr, Nicolau RA. The effects of LED
emissions on sternotomy incision repair after myocardial
revascularization: A randomized double-blind study with
follow-up. Lasers Med Sci. 2014;29:1195–202.
Pinto NC, Pereira MH, Stolf NA, Chavantes MC. Low
level laser therapy in acute dehiscence saphenectomy:
therapeutic proposal. Rev Bras Cir Cardiovasc.
;24(1):88-91.
Pinto NC, Pereira MH, Tomimura S, de Magalhães AC,
Pomerantzeff PM, Chavantes MC. Low-level laser therapy
prevents prodromal signal complications on saphenectomy
post myocardial revascularization. Photomed Laser
Surg. 2014;32(6):330-5.
de Barros Araújo Júnior R, Gonzaga ICA, Fernandes GA,
Lima ACG, Cortelazzi PST, de Oliveira RA, et al. Low-intensity
LED therapy (λ 640 ± 20 nm) on saphenectomy
healing in patients who underwent coronary artery bypass
graft: a randomized, double-blind study. Lasers Med Sci.
;33(1):103-9.
Kovlen DV, Ponomarenko GN. [Physical therapy and
rehabilitation of patients with coronary heart disease: scientometric analysis of evidence-based studies]. Fizioterapiya,
bal’neologiya i reabilitaciya [Physiotherapy, balneology
and rehabilitation]. 2015;14(2):11-16. (in Russian)
Kovlen DV, Ponomarenko GN. [Physical therapy of hypertension:
scientometric analysis of evidence-based studies].
Fizioterapiya, bal’neologiya i reabilitaciya [Physiotherapy,
balneology and rehabilitation]. 2017;16(3):121-7.
doi: http://dx.doi.org/10.18821/1681-3456-2017-16-
-121-127
Agov BS, Devyatkov ND, Zhuk LE. [The use of laser radiation
in coronary heart disease]. Klinicheskaya medicina
[Clinical medicine]. 1982;5:65-7. (in Russian)
Kulikov VYu, Kim LB, Azbel’ DI, Dzyuba MT. [The antioxidant
effect of laser therapy in patients with coronary
heart disease and post-infarction cardiosclerosis]. Byull.
SO AMN SSSR [Bull. SB AMS USSR]. 1987;6:121-3.
(in Russian)
Belyaev AA, Ragimov SE, Afanas’eva LS. [The use of
lasers in cardiovascular diseases: the beginning of a long
journey]. Terapevticheskij arhiv [Therapeutic Archive].
;5:139-46. (in Russian)
Vasil’ev AP, Strel’cova NN, Kiyanyuk NS. [Stress-limiting
effect of low-intensity laser radiation in patients with
coronary heart disease]. Voprosy kurortologii, fizioterapii
i lechebnoj fizicheskoj kul’tury [Questions of balneology,
physiotherapy]. 1997;6:3-5. (in Russian)
Vladimirov, YuA. Tri gipotezy o mekhanizme dejstviya
krasnogo (lazernogo) sveta. Efferentnaya medicina
[Three hypotheses about the mechanism of action of red
(laser) light. Efferent medicine]. Moscow: NII fiz.-him.
mediciny Publ.; 1994:23-35. (in Russian)
Gamaleya NF. Aktual’nye voprosy mekhanizma biologicheskogo
dejstviya izlucheniya lazerov. Primenenie
metodov i sredstv lazernoj tekhniki v biologi i medicine
[Actual questions of the mechanism of the biological effect
of laser radiation. Application of methods and means
of laser technology in biology and medicine]. Kiev; 1981.
P. 128-34. (in Russian)
Illarionov VE. Osnovy lazernoj terapii [The basics of laser
therapy]. Moscow: Respekt Publ.; 1992. p. 123. (in Russian)
Kipshidze NN. Chapidze GE, Korochkin IM. Lechenie
ishemicheskoj bolezni serdca gelij-neonovym lazerom
[Treatment of coronary heart disease with a helium-neon
laser]. Tbilisi: Amirani Publ.; 1993. 192 p. (in Russian)
Meshalkin EN, Sergievskij VS. Rezul’taty i perspektivy
primeneniya gelij-neonovyh lazerov v kardiohirurgii.
Primenenie pryamogo lazernogo oblucheniya v eksperimental’noj
i klinicheskoj kardiohirurgii [Results and
prospects for the use of helium-neon lasers in cardiac surgery.
The use of direct laser irradiation in experimental
and clinical cardiac surgery]. Novosibirsk; 1981. P. 6-28.
(in Russian)
Mihno LE, Krivoruchenko AI. [Laser therapy for coronary
heart disease]. Med. reabilitaciya, kurortologiya, fizioterapiya
[Med. rehabilitation, balneology, physiotherapy].
;2:55-61. (in Russian)
Sorokina EI, Kenevich NA. [On the comparative effect
of laser radiation of various ranges on patients with
coronary heart disease]. Vopr. kurort., fizioter. i LFK
[Q. resort., fizioter. and exercise therapy]. 1997;4:11-3.
(in Russian)
Shuvalova IN. [The effect of repeated laser therapy courses
on blood pressure and exercise tolerance in patients
with essential hypertension in combination with coronary
heart disease]. Ukr. kardіol. zhurn. [Ukr. cardіol. journal].
;12:69-71. (in Russian)