The significance of the distribution of the indicators of humoral and cell immunity and their role in the pathogenesis of bronchial asthma in children with the position of system analysis
Abstract
Bronchial asthma is one of the common diseases in children of different ages. In recent years, around the world, including in Ukraine, there is a trend towards its sustainable growth. To date, there are no methods of systemic immunodiagnostics that would allow with high diagnostic accuracy to identify clinical forms and severity of asthma, which would allow more fully reveal the pathogenetic mechanisms and individualize approaches to the treatment of asthma in children.
The aim of this work was to study the hierarchy of immunological parameters in the pathogenetic matrix, which will determine the features of clinical forms and severity of asthma in children on the basis of systematic analysis.
A comprehensive clinical and immunological examination of 176 children with asthma aged 6 to 15 years. To detect the autoimmune component used lipopolysaccharide antigens obtained from homologous cell-tissue structures of the trachea, bronchi and lung tissue from sectional samples of the bronchopulmonary system from accidentally killed children with group I (0) blood 2–4 hours after death. The level of autoantibodies to lipopolysaccharide antigens of the bronchopulmonary system was determined by quantifying the autoantibody index – Qφ.
As a result of the study for the first time to improve the diagnosis and differentiation of clinical forms and severity of asthma from the standpoint of system analysis was developed immunodiagnostic complex, which took into account the degree of deviation from the norm values (Student's t-test, t = 1.96) and their distribution in pathogenetic matrix. This approach to ranking the positions of immunological parameters allowed to determine the features of humoral and cellular immunity, the process of apoptosis of cell-tissue structures of the bronchopulmonary system and the autoimmune component in the pathogenesis of asthma in children, which opens approaches to individualization of pathogenetic therapy.
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References
Maydannyk VH, Besh LV, Koloskova OK, Smiyan OI. Bronkhialʹna astma u ditey: novi klinichni rekomendatsiyi. Mizhnar. zhurn. pediatriyi, akusherstva ta hinekolohiyi. 2018;12(1):28-42. http://ijpog.org/downloads/30/Oglad1.pdf
Yu. I. Feshchenko, L. O. Iashyna, D. M. Boiko, V. K. Gavrysiuk, O. O. Krakhmalova, L. F. Matiukha, Yu. M. Mostovoy, T. O. Pertseva, M. O. Polianska, O. M. Rekalova, M. M. Ostrovsky, S. V. Zaikov, L. I. Konopkina, T. V. Konstantinovich. ADAPTED EVIDENCE-BASED CLINICAL GUIDELINES: BRONCHIAL ASTHMA (Part 1), ASTHMA AND ALLERGY. 2020;2:5-26. https://doi.org/10.31655/2307-3373-2020-2-5-26
Chernusky VG, Govalenkova OL, Letyago AV, Evdokimova TV. CONCEPTION OF IMMUNOPATHOLOGICAL MECHANISMS DEVELOPMENT IN CHILDREN WITH BRONCHIAL ASTHMA. Medicine today and tomorrow. 2015;1(66): 56-61.
Chernuskyi V, Popov M, Hovalenkova O, Letiaho H, Evdokymova T, Tolmachova S, Popova A. Autoimmune reactions in the bronchial asthma in children induced heterophilic antigenes of microorganism of bronchopulmants. Journal KhNU [Internet]. 1Oct.2019 [cited 19Mar.2021];(38). Available from: https://periodicals.karazin.ua/medicine/article/view/14352
Chernushenko E.F., Kogosova KS. (1978) Immunological research in the clinic. Kiev: Zdorov'ya, 160 s.
Anderson WC, Apter AJ, Dutmer CM. [et al]. Advances in asthma in 2016: Designing individualized approaches to management. J. Allergy Clin. Immunol. 2017; 140: 671–680. https://doi.org/10.1016/j.jaci.2017.06.015
Asamoah F, Kakourou A, Dhami S. Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews. Clin. Transl. Allergy. 2017; 7: 25.
Ducharme FM, Jensen ME, Mendelson MJ. [et al]. Asthma Flare-up Diary for Young Children to monitor the severity of exacerbations. J. Allergy Clin. Immunol. 2016;137: 744–749. https://doi.org/10.1016/j.jaci.2015.07.028
Pedersen S. Asthma control in children: Is it important and can we measure it? Paediatr. Respir. Rev. 2016;17:36-8. https://doi.org/10.1016/j.prrv.2015.08.009
Prevention (2017 Update), 155. Available from: www.ginasthma.org.
Shilpa J., Patel and Stephen J. Asthma. Pediatrics in Review. 2019. 40 (11): 549–567. https://doi.org/10.1542/pir.2018–0282
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