Autoimmune reactions in the bronchial asthma in children induced heterophilic antigenes of microorganism of bronchopulmants

  • Viacheslav Chernuskyi V. N. Karazin Kharkiv National University, School of Medicine, Doctor of Medicine, Full Professor https://orcid.org/0000-0001-5657-9486
  • Mykola Popov V. N. Karazin Kharkiv National University, School of Medicine, Doctor of Medicine, Full Professor, V. N. Karazin Kharkiv National University, School of Medicine, Doctor of Medicine, Full Professor https://orcid.org/0000-0002-5759-9654
  • Olha Hovalenkova V. N. Karazin Kharkiv National University, School of Medicine, Candidate of Medicine, Associate Professor https://orcid.org/0000-0002-6403-7625
  • Hanna Letiaho V. N. Karazin Kharkiv National University, School of Medicine, Candidate of Medicine, Associate Professor https://orcid.org/0000-0002-6327-1321
  • Tetyana Evdokymova V. N. Karazin Kharkiv National University, School of Medicine, Candidate of Medicine, Assistant
  • Svitlana Tolmachova V. N. Karazin Kharkiv National University, School of Medicine, Candidate of Medicine, Associate Professor https://orcid.org/0000-0001-6074-4114
  • Alisa Popova Student of V. N. Karazin Kharkiv National University, School of Medicine
Keywords: bronchial asthma, children, microorganisms, heterophilic antigens, autoimmune process

Abstract

Introduction. At the present stage of development of the problem in the etiopathogenesis of  bronchial asthma (BA) in children, regardless of form, one of the leading places belongs to the microbial factor. Aim. The aim of the work was to study the development of autoimmune reactions to the cellular tissue structures of the trachea, bronchi and lung tissue, stimulated by heterophilic antigens of the microbiota of the bronchopulmonary system of children with BA. Materials and methods. A total of 97 children with BA aged 7 to 15 years were examined. The diagnosis of the disease was established according to GINA (2017) and the order of the Ministry of Health of Ukraine dated 08.10.2013 No. 868. Heterophilic antigens of bronchopulmonary structures in microbiota were determined using hyperimmune organ-specific rabbit sera to antigens of the trachea, bronchi and lung tissue. Lipopolysaccharide antigens from homologous cell-tissue structures of the trachea, pulmonary bronchi were determined, water-salt antigens from the structures of the trachea, bronchi, and lung tissue were obtained from accidentally dead children with I (0) blood group. The level of autoantibodies to antigens of the bronchopulmonary system with the quantitative calculation of the indicator Qφ was determined in the nephelometric reaction. Results. In the work it was shown experimentally that microorganisms, isolated from sputum of children, patients with asthma in the period of exacerbation, varying their antigenic potential, are able to include in their structure  heterophilic antigens of cell-tissue structures of the bronchopulmonary system. Microorganisms including in their structure heterophilic antigens of the trachea, bronchi and lung tissue not only determine the induction of the pathological process in the bronchopulmonary system, but also translate it into an autoimmune basis, exacerbating the severity of the course of the disease. Conclusions. The study showed that the proposed methods are important for clarifying the etiopathogenesis of BA in children and disclosing the mechanism for switching the pathological process in the bronchopulmonary system to an autoimmune basis and can be used to develop new approaches for the etiopathogenetic treatment of the disease.

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Author Biographies

Viacheslav Chernuskyi, V. N. Karazin Kharkiv National University, School of Medicine, Doctor of Medicine, Full Professor

Yuvileinyi Avenue, 52a, Kharkiv, Ukraine, 61153

Mykola Popov, V. N. Karazin Kharkiv National University, School of Medicine, Doctor of Medicine, Full Professor, V. N. Karazin Kharkiv National University, School of Medicine, Doctor of Medicine, Full Professor

Svobody Square, 6, Kharkiv, Ukraine, 61022

Olha Hovalenkova, V. N. Karazin Kharkiv National University, School of Medicine, Candidate of Medicine, Associate Professor

Yuvileinyi Avenue, 52a, Kharkiv, Ukraine, 61153

Hanna Letiaho, V. N. Karazin Kharkiv National University, School of Medicine, Candidate of Medicine, Associate Professor

Yuvileinyi Avenue, 52a, Kharkiv, Ukraine, 61153

Tetyana Evdokymova, V. N. Karazin Kharkiv National University, School of Medicine, Candidate of Medicine, Assistant

Yuvileinyi Avenue, 52a, Kharkiv, Ukraine, 61153

Svitlana Tolmachova, V. N. Karazin Kharkiv National University, School of Medicine, Candidate of Medicine, Associate Professor

Yuvileinyi Avenue, 52a, Kharkiv, Ukraine, 61153

Alisa Popova, Student of V. N. Karazin Kharkiv National University, School of Medicine

Svobody Square, 6, Kharkiv, Ukraine, 61022

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Published
2019-10-01
How to Cite
Chernuskyi, V., Popov, M., Hovalenkova, O., Letiaho, H., Evdokymova, T., Tolmachova, S., & Popova, A. (2019). Autoimmune reactions in the bronchial asthma in children induced heterophilic antigenes of microorganism of bronchopulmants. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (38). https://doi.org/10.26565/2313-6693-2019-38-01