Molecular Docking Study Of Protein-Functionalized Carbon Nanomaterials For Heavy Metal Detection And Removal

  • Olga Zhytniakivska Department of Medical Physics and Biomedical Nanotechnologies, V.N. Karazin Kharkiv National University,Kharkiv, Ukraine https://orcid.org/0000-0002-2068-5823
  • Uliana Tarabara Department of Medical Physics and Biomedical Nanotechnologies, V.N. Karazin Kharkiv National University,Kharkiv, Ukraine https://orcid.org/0000-0002-7677-0779
  • Kateryna Vus Department of Medical Physics and Biomedical Nanotechnologies, V.N. Karazin Kharkiv National University,Kharkiv, Ukraine https://orcid.org/0000-0003-4738-4016
  • Valeriya Trusova Department of Medical Physics and Biomedical Nanotechnologies, V.N. Karazin Kharkiv National University,Kharkiv, Ukraine https://orcid.org/0000-0002-7087-071X
  • Galyna Gorbenko Department of Medical Physics and Biomedical Nanotechnologies, V.N. Karazin Kharkiv National University,Kharkiv, Ukraine https://orcid.org/0000-0002-0954-5053
DOI: https://doi.org/10.26565/2312-4334-2024-3-59
Keywords: Carbon-based nanomaterials, Heavy metals, β-lactoglobulin, v

Abstract

Carbon nanomaterials (CNMs) have emerged as highly effective agents for the removal of heavy metals from contaminated water and environments, owing to their unique structural and chemical properties. However, the hydrophobic nature of CNMs and their tendency to aggregate in most solvents present significant challenges to their practical application. Functionalizing carbon-based nanomaterials with proteins offers a promising solution to these issues, potentially leading to systems with unprecedented performance. Before fabricating protein-CNM systems for heavy metal detection and removal, it is crucial to evaluate the metal-binding affinity and potential interaction modes using computational approaches. In this study, a molecular docking technique was employed to investigate the interactions among heavy metal salts (AsO₄, Cd(NO₃)₂, Fe(NO₃)₃, NiSO₄, PbSO₄, PtCl₄), carbon-based nanomaterials (fullerenes C₂₄ and C₆₀, and single-walled carbon nanotubes), and β-lactoglobulin. The docking results revealed that: 1) the size, shape, and surface properties of carbon-based materials significantly influence the ability of β-lactoglobulin-CNM complexes to interact with different heavy metals; 2) different heavy metal salts exhibit distinct preferences for the various nanosystems; 3) hydrogen bonding and hydrophobic interactions play a significant role in the complexation of heavy metal salts with β-lactoglobulin-carbon-based materials.

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Published
2024-09-02
Cited
How to Cite
Zhytniakivska, O., Tarabara, U., Vus, K., Trusova, V., & Gorbenko, G. (2024). Molecular Docking Study Of Protein-Functionalized Carbon Nanomaterials For Heavy Metal Detection And Removal. East European Journal of Physics, (3), 484-490. https://doi.org/10.26565/2312-4334-2024-3-59
Issue
No. 3 (2024): East European Journal of Physics
Section
Original Papers

Copyright (c) 2024 O. Zhytniakivska, U. Tarabara, K. Vus, V. Trusova, G. Gorbenko

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