Acid resistance of rabbits erythrocyte with experimental diabetes and application of glucose-lowering agents
Keywords:
erythrocyte, diabetes, acid hemolysis, erythrogramAbstract
This paper covers the study of erythrocyte resistance to acid hemolysis in rabbits with the experimental
model of dexamethasone type 2 diabetes by application of glucose-lowering agents. As samples rabbit
erythrocytes with diabetes mellitus, rabbit erythrocytes treated with the metformin and experimental
compound 1408 and intact individuals had been used. Hemolysis curves were obtained using
photoelectrocolorimeter FEK-M (maximum light transmission λ=740 nm). The study revealed that in
experimental diabetes mellitus in rabbits observed change in shape erythrocytes, and reduced the number of erythrocytes increased resistance. During the treatment with metformin there has been recorded the approximation of the erythrogram key indicators of rabbit erythrocytes in this group, to the erythrogram indicators of erythrocyte suspensions in the rabbit control group, which may indicate the restoration of physical and chemical properties of red blood cells. Application of experimental compounds increases in erythrocytes increased resistance, but it does not affect the recovery of the architectonics of the erythrocyte
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