Influence of type 2 diebetes on dielectric characteristics of rat erythrocytes
Keywords:
permeability, erythrocytes, erythrocyte membranes, type 2 diabetesAbstract
The paper deal with the results of investigation of the type 2 model diabetes and sugar-reducing drugs
influence on the dielectric parameters of erythrocyte suspensions in rats by microwave dielectrometry at
the operating frequency 9,2 GHz. A tendency towards the increase in the average values of real and
imaginary components of complex permittivity in red blood cells suspensions of rats with experimental
type 2 diabetes has been researched, as well as the changes in these parameters during the treatment with
various drugs. The dispersion of the values of the real part of complex dielectric permittivity of
suspensions of red blood cells of rats with experimental type 2 diabetes is significantly greater than the
variance of the values of the corresponding parameter of the control group. This may be stipulated by the
different character of changes in the ratio free/bound water in the erythrocytes of different animals, i.e.,
different response of the individual organism on pathology at the cellular level. In all groups of the
animals with model diabetes, both corrected and uncorrected, ε' is a more variable parameter than ε'',
which suggests a greater sensitivity of ε' to pathological changes that occur in cells. The method of
microwave dielectrometry at the operating frequency 9,2 GHz is a promising method for integrated
assessment of the structural changes of water properties in the interface erythrocyte-water, and can be
recommended to monitor the dynamics of the erythrocytes state of patients in the course of treatment.
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