Manifestation of intermolecular hydrogen bond in hetero-complexes of biologically active substances probed by the methods of vibrational spectroscopy

Authors

  • Iu. N. Blyzniuk Institute of Radiophysics and Electronics, National Academy of Sciences of Ukraine Author
  • M. A. Semenov Institute of Radiophysics and Electronics, National Academy of Sciences of Ukraine Author
  • T. V. Bolbukh Institute of Radiophysics and Electronics, National Academy of Sciences of Ukraine Author
  • H. V. Shestopalova Institute of Radiophysics and Electronics, National Academy of Sciences of Ukraine Author
  • V. Ya. Maleev Institute of Radiophysics and Electronics, National Academy of Sciences of Ukraine Author

Keywords:

hetero-association, hydrogen bonding, infrared spectroscopy, Raman spectroscopy, biologically active substances

Abstract

The investigation of the hetero-association of biologically active substances (flavin mononucleotide
(FMN), ethidium bromide (EB), proflavine (PRF), theophylline (TPH) and caffeine (CAF)) was carried in
neutral aqueous solutions by IR and Raman spectroscopy. The analysis of IR and Raman spectra showed
the formation of intermolecular hydrogen bonds between the functional groups (C=O and NH2) in FMNEB, FMN-PRF and TPH-EB heterocomplexes. The observed shift of vibration frequencies of carbonyl
groups in the IR spectra allowed us to estimate the values of the enthalpy of H-bonds. It is shown that
intermolecular hydrogen bonds additionally stabilize these structures.

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Author Biographies

  • Iu. N. Blyzniuk, Institute of Radiophysics and Electronics, National Academy of Sciences of Ukraine

    12 Ak.Proskura str., Kharkiv, 61085

  • M. A. Semenov, Institute of Radiophysics and Electronics, National Academy of Sciences of Ukraine

    12 Ak.Proskura str., Kharkiv, 61085

  • T. V. Bolbukh, Institute of Radiophysics and Electronics, National Academy of Sciences of Ukraine

    12 Ak.Proskura str., Kharkiv, 61085

  • H. V. Shestopalova, Institute of Radiophysics and Electronics, National Academy of Sciences of Ukraine

    12 Ak.Proskura str., Kharkiv, 61085

  • V. Ya. Maleev, Institute of Radiophysics and Electronics, National Academy of Sciences of Ukraine

    12 Ak.Proskura str., Kharkiv, 61085

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Issue

Vol. 2 No. 27 (2011): Біофізичний вісник

Section

Molecular biophysics

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How to Cite

Manifestation of intermolecular hydrogen bond in hetero-complexes of biologically active substances probed by the methods of vibrational spectroscopy. (2015). Biophysical Bulletin, 2(27). https://periodicals.karazin.ua/biophysvisnyk/article/view/2524

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