HYDRATION AND STABILITY OF NUCLEIC ACIDS WITH DIFFERENT AT- AND GC - COMPOSITION IN CONDENSED STATE
Keywords:
IR-spectroscopyAbstract
In the suggested review the results of the investigation of influence of water on structure and stability of nucleic acids (NA) are generalized on the basis of literature dates and our method of studies of peculiarity hydration of NA with different nucleotide composition in the system NA-water with variable water content. An analysis showed that contribution of the water molecules in total energy of stabilization of helical structure of nucleic acids is up to 70-75% and contribution of H-bonds of Watson-Crick pairs in this energy does not exceed 25%. These results allowed to bring out effect of other factors except influence of water on formation and stabilization of DNA hydration shell.
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