Meta-analysis of the association of T102C polymorphism in HTR2A gene of 5-HT2A receptor and schizophrenia
Keywords:
meta-analysis, T102C polymorphism, 5HT2A receptor, schizophrenia, HTR2A gene
Abstract
HTR2A gene codes the serotonin receptor 5-HT2A and is located on the long arm of chromosome 13. A marked decrease in the density of these receptors in different areas of the cortex was observed in the brains of patients with schizophrenia. This meta-analysis confirmed the connection between schizophrenia and a marker on the long arm of chromosome 13 as a C-allelic form of T102C polymorphism of HTR2A gene. Previous studies have shown that this association is more prominent in European samples, while in East Asia it is absent. This study defines that the strongest association takes place in the Russian samples, where the value of the odds ratio for the C allele is: OR=2,1; 95% CI 1,5–2,9; for the genotype CC OR=3,9; 95% CI 2,1–7,4. In populations of other countries (Israel, Brazil, Finland, Canada) such association was not revealed. The fact that the association of T102C polymorphism with schizophrenia has been confirmed for the Russian population that is genetically close to Ukrainian, is an important precondition for such research in Ukraine to determine provocative allele to find the risk of schizophrenia, to carry out pharmacogenetic studies etc.Downloads
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References
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Краснов В.Н., Гурович И.Я., Мосолов С.Н. и др. Стандарты оказания помощи больным шизофренией. – Москва, 2006. (http://www.labclinpharm.ru/35.html). /Krasnov V.N., Gurovich I.Ya., Mosolov S.N. i dr. Standarty okazaniya pomoshchi bol'nym shizofreniyey. – Moskva, 2006./
Траилин А.В., Левада О.А. Генетика и эпигенетика шизофрении // Нейро news. – 2012. – Т.6, №41. (http://neuronews.com.ua/page/genetika-i-epigenetika-shizofrenii). /Trailin A.V., Levada O.A. Genetika i epigenetika shizofrenii // Neyro news. – 2012. – T.6, №41./
Ягода С.А. Биомаркеры шизофрении и пути объективизации психофармакотерапии // Современная терапия психических расстройств. – 2011. – №2. – С. 2–7. /Yagoda S.A. Biomarkery shizofrenii i puti ob’yektivizatsii psikhofarmakoterapii // Sovremennaya terapiya psikhicheskikh rasstroystv. – 2011. – №2. – S. 2–7./
Anttila S., Kampman O., Illi A. et al. Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach // BMC Psychiatry. – 2007. – Vol.7. – 22p.
Borenstein M., Hedges L.V., Higgins J.P.T., Rothstein H.R. Introduction to meta-analysis. – Chichester: Wiley, 2009. – 421p.
Correa H., De Marco L., Boson W. et al. Association study of T102C 5-HT(2A) polymorphism in schizophrenic patients: diagnosis, psychopathology, and suicidal behavior» // Dialogues Clin. Neuroscience. – 2007. – Vol.9. – P. 97–101.
Inayama Y., Yoneda H., Sakai T. et al. Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia // Am. J. Med. Genet. – 1996. – Vol.67. – P. 103–105.
Joober R., Benkelfat C., Brisebois K. et al. T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variability // Journal of Psychiatry and Neuroscience. – 1999. – Vol.24, no 2. – P. 141–146.
Kushniarevich A., Utevska O., Chuhryaeva M. et al. Genetic heritage of the Balto-Slavic speaking populations: a synthesis of autosomal, mitochondrial and Y-chromosomal data // PLOS ONE. – 2015. (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135820)
Abdomaleky H.M., Faraone S.V., Glatt S.J., Tsuang M.T. Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia // Schizophrenia Research. – 2004. – Vol.67. – P. 53–62.
Polesskaya O.O., Sokolov B.P. Differential expression of the ‘‘C’’ and ‘‘T’’ alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics // J. Neurosci. Res. – 2002. – Vol.67. – P. 812–822.
Segman R.H., Heresco-Levy U., Finkel B. et al. Association between the serotonin 2A receptor gene and tardive dyskinesia in chronic schizophrenia // Molecular Psychiatry. – 2001. – Vol.6. – P. 225–229.
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How to Cite
Безугла, О. М. (1). Meta-analysis of the association of T102C polymorphism in HTR2A gene of 5-HT2A receptor and schizophrenia. The Journal of V.N.Karazin Kharkiv National University. Series «Biology», 27, 46-50. Retrieved from https://periodicals.karazin.ua/biology/article/view/8021
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