The influence of the Rhenium-Platinum system on biochemical parameters of tumor-bearing rats’ liver

Abstract

The influence of the Rhenium-Platinum system on biochemical characteristics of liver of tumor-bearing rats with cisplatin resistant Guerin carcinoma (RGC) was investigated and comparison with the parameters of rat liver with ordinary Guerin carcinoma (GC) was made. It was shown that introduction of rhenium compounds resulted in normalization of diagnostic enzymes activity in the blood (enzemia) and in activation of the enzymes in the liver tissue. Administration of antitumor Rhenium-Platinum system led to activation of gamma-glutamyl cycle in the liver of rats’ tissue with RGC in comparison with GC group. Introduction of the system reduced activity of radical processes and increased activity of antioxidant enzymes, concentration of glutathione and enzyme activity of the glutathione cycle protection in the tissues of rats with GC and especially in RGC. That may explain reducing of enzemia and hepatocellular distrophia. There was proposed a mechanism of action of powerful antioxidants with quadruple bond in regard to hepatoprotection regulation involving participation of the glutathione defense system and to oxidation stress regulation of rats whose bodies contain cisplatin-resistant tumor. The conclusion was drawn regarding the prospects of using nanoliposomatic forms of cytostatics in anticancer therapy.