Neurodegenerative changes and locomotor activity in Drosophila melanogaster at tissue-specific expression of Sod1 gene in glial cells
Abstract
It has been established that functional inactivation of Sod1 gene and its overexpression in glial cell results in neurodegenerative changes in the optical lobe of D. melanogaster brain. Conventional area of dead tissue sectors in older (21-day) imagoes was from 141,521±12,369 mm2 to 149,178±36,564 mm2 in the cases of a knockout and overexpression respectively. In experimental animals there has been observed the decrease in the width of the first optic ganglion – lamin: 23,689±1,080 mm and 17,969±1,266 mm in the cases of inhibition and overexpression respectively; in control flies the brain tissue remained intact, lamin width was 30,012±1,560 mm. In older individuals with functional knockout of the gene Sod1 in glial cells excessive locomotor activity has been observed in comparison with the control individuals of the same age.
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