Effect of Ni2+ on inactivation properties of wild type (Саv3.1w/t) and mutant (Cav3.1Q172H) calcium channels

  • О. В. Носаль
  • О. І. Болдирєв
  • О. П. Любанова
  • Я. М. Шуба
Keywords: T-type calcium channels; Са2 ; Xenopus oocytes; Ni2 ×

Abstract

Тhe aim of study was to investigate the effect of Ni2+ on Саv3.1w/t- and Саv3.1Q172H-channels inactivation. Membrane currents in the oocytes were recorded using a conventional double-microelectrode voltage-clamp technique. It is shown that in the presence of either Sr2+ (except the Саv3.1Q172H-channels) or Ba2+, but not Ca2+, as an extracellular charge carrier, for both channels, the shift in stationary inactivation parameters was statistically significant.

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References

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Published
2013-05-22
Cited
How to Cite
Носаль, О. В., Болдирєв, О. І., Любанова, О. П., & Шуба, Я. М. (2013). Effect of Ni2+ on inactivation properties of wild type (Саv3.1w/t) and mutant (Cav3.1Q172H) calcium channels. The Journal of V.N.Karazin Kharkiv National University. Series «Biology», 18(1079), 161-163. Retrieved from https://periodicals.karazin.ua/biology/article/view/13756
Section
PHYSIOLOGY OF HUMAN AND ANIMALS