Effect of Ni2+ on inactivation properties of wild type (Саv3.1w/t) and mutant (Cav3.1Q172H) calcium channels
Abstract
Тhe aim of study was to investigate the effect of Ni2+ on Саv3.1w/t- and Саv3.1Q172H-channels inactivation. Membrane currents in the oocytes were recorded using a conventional double-microelectrode voltage-clamp technique. It is shown that in the presence of either Sr2+ (except the Саv3.1Q172H-channels) or Ba2+, but not Ca2+, as an extracellular charge carrier, for both channels, the shift in stationary inactivation parameters was statistically significant.
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References
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